High-grade myxoinflammatory fibroblastic sarcoma: a report of 23 cases

Kazakov, Dmitry V.; Hadravský, Ladislav; Kinkor, Z; Michal, Michal

doi:10.1016/j.anndiagpath.2015.03.012

Cited by 37 publications

(46 citation statements)

References 24 publications

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“…Laskin et al 16 reported 104 cases of MIFS, and of 59 cases with accessible follow-up, only one presented with metastatic disease. Michal et al 6 collected 23 cases of high-grade MIFS out of which 9 developed a metastatic disease which became fatal for 7 patients.…”

Section: Discussionmentioning

confidence: 99%

“…Also cells with large bizarre nuclei resembling Reed-Sternberg/Hodgkin's cells are frequently found. 1,[4][5][6] A common feature is the presence of areas of myxoid changes and infiltration of inflammatory cells including lymphocytes, plasma cells, and macrophages in the tumor tissue. 1 MIFS is generally considered a neoplasm of low malignancy with propensity for local recurrence after incomplete removal.…”

Section: Introductionmentioning

confidence: 99%

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Establishment of a spontaneously transformed cell line (JU-PI) from a myxoinflammatory fibroblastic sarcoma

et al. 2018

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Myxoinflammatory fibroblastic sarcoma is a soft-tissue neoplasm most frequently found in the distal extremities of middle-aged adults. Most myxoinflammatory fibroblastic sarcoma are low-grade tumors with propensity for local recurrence after incomplete removal. We report a myxoinflammatory fibroblastic sarcoma which developed in the foot of a 41-year-old male and showed an exceptionally aggressive course with metastatic spread and fatal outcome within 16 months. We managed to establish a spontaneously transformed continuous cell line, called JU-PI, from a metastatic lesion. The JU-PI cells have a sub-tetraploid karyotype including the 1;10 chromosomal translocation and amplification of the proximal end of 3p; these features are considered genetic signatures of myxoinflammatory fibroblastic sarcoma. Both the primary tumor and the JU-PI cells showed nuclear expression of the TFE3 transcription factor but TFE3-activating chromosomal rearrangements were not found. To our knowledge, JU-PI is the first established myxoinflammatory fibroblastic sarcoma cell line. JU-PI cells offer a tool for investigating the molecular oncology of myxoinflammatory fibroblastic sarcoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Establishment of a spontaneously transformed cell line (JU-PI) from a myxoinflammatory fibroblastic sarcoma

et al. 2018

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“…The proportions of these components vary greatly from case to case . Michal et al have suggested the presence of emperipolesis as an additional diagnostic criterion, recommending the use of cyclin D1 to identify engulfed inflammatory cells in the cytoplasm of tumor cells.…”

Section: Commentsmentioning

confidence: 99%

Myxoinflammatory fibroblastic sarcoma: A rare case affecting only the dermis

et al. 2020

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“…The frequency of MIFS is significantly higher than those of PHAT and HFLT; more than 200 cases have been reported. [2][3][4][43][44][45] Most patients are adults in the fifth or sixth decade of life (range, 4-93 years), with equal sex distribution. The common clinical presentation is a slowly growing, illdefined mass at the dorsal part of distal extremities (fingers, hands, wrists, toes, feet, ankles), with or without pain or tenderness.…”

Section: Myxoinflammatory Fibroblastic Sarcomamentioning

confidence: 99%

“…[8][9][10] Several experts propose that PHATs may merely be MIFS associated with angiectatic-hyalinized vessels because of their morphologic similarities. 44,54 We recently diagnosed a slowly growing subcutaneous mass on the ankle of a 56-year-old woman as PHAT (Figure 2, A through D). HFLT-like (Figure 2, E) and MIFS-like (Figure 2, F through H) lesions were identified in different areas of this case.…”

Section: The Intertwined Relationship Between Phat Hflt and Mifsmentioning

confidence: 99%

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

Liu

Sukov

2018

Archives of Pathology &Amp; Laboratory Medicine

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- Diagnosis of HFLT, PHAT, and MIFS is challenging because of a lack of unique morphologic, immunophenotypic, molecular, and cytogenetic markers. The recurrent t(1;10)(p22;q24) translocation and/or TGFBR3/MGEA5 rearrangement was reported in 55 patients, with a relatively even distribution among HFLT, PHAT, and MIFS (17 HFLT, 15 MIFS, 13 MIFS/HFLT, and 10 PHAT). This indicates that current morphology-based diagnostic criteria do not identify reliably the subset of soft tissue tumor with t(1;10) translocation. Genetic heterogeneity of these tumors is supported by the recent detection of a mutually exclusive, second recurrent genetic change, t(7;17) TOM1L2-BRAF translocation or BRAF amplification, in a subset of MIFS.

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High-grade myxoinflammatory fibroblastic sarcoma: a report of 23 cases

Cited by 37 publications

References 24 publications

Establishment of a spontaneously transformed cell line (JU-PI) from a myxoinflammatory fibroblastic sarcoma

Establishment of a spontaneously transformed cell line (JU-PI) from a myxoinflammatory fibroblastic sarcoma

Myxoinflammatory fibroblastic sarcoma: A rare case affecting only the dermis

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

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