High-Grade Inflammation in Renal Failure Patients, According to Mean Platelet Volume, Improves at the End of Two Years After Transplantation

Bilen, Yusuf; Çankaya, Erdem; Keleş, Mustafa; Uyanik, Abdullah; Aydınlı, Bülent; Bilen, Nurhan

doi:10.1016/j.transproceed.2015.04.035

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…The findings above expand our knowledge on the clinical significance of platelet count in AS patients. Platelet parameters have been suggested as important markers of inflammation (Bilen et al, 2015;Kalelioglu et al, 2015;Akboga et al, 2016;Koupenova et al, 2018). Unlike other rheumatic disease such as SLE and Sjögren's syndrome (SjS), AS is a rheumatic disease characterized by serious inflammatory responses (Vanaki et al, 2018;Vinker Shuster et al, 2018;Steiner et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Associations of Platelet Count with Inflammation and Response to Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis

et al. 2020

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Background: Increased platelet count has been reported in ankylosing spondylitis (AS) patients, but its clinical significance is still largely elusive. The objective of this study was to evaluate the clinical role of platelet count in AS patients, especially its impact on treatment outcomes. Methods: A case-control study containing 35 AS patients receiving anti-tumor necrosis factor-α (anti-TNF-α) therapy and 45 healthy controls was performed, and AS patients were followed at least 6 months after anti-TNF-α therapy. A systematic review and metaanalysis of studies containing relevant data on outcomes of interest was also performed. Results: AS patients had significantly higher platelet count than controls (p 0.0001), and the significantly increased platelet count in AS patients was confirmed in a metaanalysis of 14 studies involving 1,223 AS patients and 913 controls (mean difference 39.61, 95% CI 27.89-51.34, p < 0.001). Besides, platelet count was significantly correlated with ESR (p < 0.001) and was moderately correlated with ASDAS-CRP score (p 0.002). Moreover, anti-TNF-α therapy could reduce platelet count in AS patients at the first month and the effect was maintained through the treatment duration. In the prospective follow-up study of those 35 AS patients, those responders to anti-TNF-α therapy had significantly lower platelet count than nonresponders (p 0.015). Logistic regression analysis suggested that lower platelet count was associated with higher possibility of achieving good response to anti-TNF-α therapy in AS patients (odds ratio 2.26; 95% CI 1.06-4.82; p 0.035). Conclusion: This study suggested that platelet count was associated with inflammation severity and treatment outcomes in AS patients, and elevated platelet count was a promising biomarker of poorer response to anti-TNF-α therapy. The findings above need to be validated in more future studies.

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Section: Discussionmentioning

confidence: 99%

Associations of Platelet Count with Inflammation and Response to Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis

et al. 2020

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“…Since patients with ESRD are at inflammatory states for a long period of time, this status could influence their platelets characteristics as they prepared themselves for inflammation. Platelet enlargement is one of the changes which can be determined by MPV (37). Therefore, it is rational that dialysis children, who are in an inflammatory state, have higher MPV values; for instance, larger platelets release greater amounts of adhesive molecules (38).…”

Section: Discussionmentioning

confidence: 99%

Importance of Mean Platelet Volume in Predicting Cardiac Mechanics Parameters and Carotid‐Intima Media Thickness in Children With End‐Stage Renal Disease and Comparison With Healthy Children

et al. 2019

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Cardiovascular disease (CVD) is the major cause of death in children with ESRD. Echocardiography and Doppler ultrasound are useful devices for diagnosing cardiovascular abnormalities in such patients. However, they are expensive, difficult to perform as a routine, and not available in many centers. Therefore, finding a more accessible and inexpensive method for CVD evaluation biomarkers is needed. The aim of this study was to evaluate the relationship between mean platelet volume (MPV) as a routine hematological parameter with cardiac mechanics characteristics in children with ESRD. Forty‐two children under dialysis and 60 age‐ and sex‐matched healthy subjects as control group were enrolled in the study. Carotid‐intima media thickness (CIMT) and echocardiographic parameters were measured in both groups. In addition, hematological and biochemical variables were evaluated in blood samples of participants. MPV was significantly higher in patients than in controls. CIMT, left ventricular mass index (LVMI), end diastolic diameter, strain rate, and global longitudinal strain were significantly different between the two groups. MPV was positively correlated with LVMI and inversely with ejection fraction. In receiver operating characteristic (ROC) curve analysis, the area under the ROC curve (AUC) values for MPV in predicting left ventricular hypertrophy (LVH) and abnormal CIMT were 0.65 (P = 0.07) and 0.53 (P = 0.74), respectively. MPV was correlated with some cardiac abnormalities in children with ESRD. However, it could not show appropriate predictive values in diagnosing LVH and subclinical atherosclerosis. Further studies with prospective design could shed more light in this topic.

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“…Also, Sharpe [24] reported that erythropoietin has an effect on thrombopoiesis in patients with chronic renal failure and increase MPV and, Yenigun [25] showed that his study might suggest that there were higher MPV values with diabetic male patients with CKD. Moreover, Bilen [26] showed that CKD patients had a decreased MPV compared with normal individuals and that it normalized at the end of the 2 nd year after renal transplantation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Mean Platelet Volume and Neutrophil/Lymphocyte Ratio in Chronic Kidney Disease Patients with Proteinurea

Seliem¹,

El-Salam

2019

The Medical Journal of Cairo University

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Background: Chronic kidney disease is a chronic inflammatory process which is the main cause of developing atherosclerosis. The main reason of morbidity and mortality in Chronic Kidney Disease (CKD) is atherosclerosis. Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte Ratio (NLR) have been reported as markers of systemic inflammation. Aim of Study: To assess the value of Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte (NLR) in chronic kidney disease patients with proteinurea. Methods: The study was carried out on two groups: Group (I): 50 CKD patients and Group (II): 50 healthy individuals as a control group. The patients were from Outpatient Clinic of Nephrology in Tanta University Hospital. This study was carried out from August 2017 to February 2018. We excluded patients suffer from coronary artery disease, myocardial infarction and heart failure, patients suffer from active infection, patients suffer from diabetes mellitus and patients suffer from malignancy. Complete clinical examination including: Body Mass Index (BMI) and routine laboratory investigations and specific investigations including Neutrophil Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) were done. Results: NLR was statistical significance higher in patients group than control healthy groups (Z mw =-7.38, p<.001) and there were statistically significant positive correlation were detected between NLR and proteinuria (p<.001*), CRP (p <.001*), fibrinogen (p<.001 *) and negative correlation with eGFR (p<.001 *). There was not statistical difference of MPV between patients group and control healthy group (t=-.510, p=.611) and there were not statistically significant correlation between MPV and proteinuria (p=.416), CRP (p=.641) and eGFR (p=.557). Conclusion: NLR could be used as a marker of inflammation and proteinuria in CKD stages but MPV needs more researches in this field.

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High-Grade Inflammation in Renal Failure Patients, According to Mean Platelet Volume, Improves at the End of Two Years After Transplantation

Cited by 7 publications

References 18 publications

Associations of Platelet Count with Inflammation and Response to Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis

Associations of Platelet Count with Inflammation and Response to Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis

Importance of Mean Platelet Volume in Predicting Cardiac Mechanics Parameters and Carotid‐Intima Media Thickness in Children With End‐Stage Renal Disease and Comparison With Healthy Children

Assessment of Mean Platelet Volume and Neutrophil/Lymphocyte Ratio in Chronic Kidney Disease Patients with Proteinurea

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