High-Grade Glioma Relationship to the Neural Stem Cell Compartment: A Retrospective Review of 104 Cases

Marsh, J. W.; Wendt, Julie; Herskovic, Arnold; Diaz, Aidnag; Gielda, Benjamin T.; Byrne, Richard W.

doi:10.1016/j.ijrobp.2010.08.036

Cited by 11 publications

(6 citation statements)

References 66 publications

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“…First, the relatively small number of patients with grade IV astrocytomas and the fact that we combined the data for astrocytoma grades I and II, and grades III and IV might have affected the grade-specific patient-based SVZ-contact rates. However, the increase in SVZ-contact rates with increasing WHO grade of gliomas was reasonable in theory, and in agreement with previous reports [ 19 , 27 , 39 ]. Second, not all SCMs were pathologically verified.…”

Section: Discussionsupporting

confidence: 93%

“…These findings suggested that the SVZ is intimately associated with the occurrence and development of gliomas. The overall SVZ-contact rate for astrocytomas was 75.2% in our study, which is lower than the rates reported by Barami et al [ 19 ] and Marsh et al [ 27 ]. There are several potential explanations for the difference between the above studies and ours.…”

Section: Discussioncontrasting

confidence: 85%

“…Another reason was the evaluation criteria. Marsh et al defined the anatomic SVZ as an area extending 5 mm from the lateral ventricle in MRI [ 27 ]. If we had used this definition of the SVZ compartment same with Marsh et al, the total patient-based SVZ-contact rate of astrocytomas would be elevated from 68.8% to 74.0% in LGA group and did not change in HGA group and SCM group.…”

Section: Discussionmentioning

confidence: 99%

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Differentiation between Solitary Cerebral Metastasis and Astrocytoma on the Basis of Subventricular Zone Involvement on Magnetic Resonance Imaging

Wang

Niu

et al. 2015

PLoS ONE

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PurposeTo determine the relationship between the subventricular zone (SVZ) and astrocytoma based on magnetic resonance imaging (MRI) and whether SVZ involvement can be used to distinguish solitary cerebral metastases (SCMs) from astrocytomas.MethodsThis retrospective study involved 154 patients with solitary low-grade astrocytoma (LGA), high-grade astrocytoma (HGA), and SCM, who underwent T1-weighted imaging (T1WI), Gd-DTPA–enhanced T1WI, and T2-weighted imaging (T2WI) or fluid-attenuated inversion recovery (FLAIR) T2WI. The spatial relationship between the tumor and SVZ was classified as “involvement” or “segregation” on contrast-enhanced T1WI for enhanced tumors and T2WI/FLAIR T2WI for non-enhanced tumors. Patient-based SVZ-contact rates were compared between the LGA, HGA, and SCM groups. The frequencies of involvement of various lateral ventricle regions by astrocytoma were compared. The correlation between SVZ involvement and tumor necrosis was analyzed.ResultsPatient-based SVZ-contact rates in SCM, LGA, and HGA were 24.1%, 68.8%, and 85.4%, respectively. Univariate analysis showed that the SVZ-contact rate was significantly different between SCM and astrocytoma (24.1% vs. 75.2% P < 0.001), also between LGA and HGA (68.1% vs. 85.4% P=0.037). After the tumor volume was adjusted as a covariate, SVZ-contact rates still differed between SCMs and astrocytomas (Odds ratio [OR]: 4.58, 95% Confidence interval [CI]: 1.65 to 12.8, P=0.004). Tumor volume differed between LGA and HGA (P< 0.001), and influenced the association between SVZ involvement and astrocytoma grade (P = 0.05). Among the lateral ventricle regions, the frontal horn was the most frequently involved by astrocytomas. SVZ-contact rates were higher in necrosis group compared with non-necrosis groups (83.9% vs. 50.0%, P < 0.001) among astrocytoma patients. Necrosis positively correlated with SVZ involvement in astrocytomas (rs = 0.342, P < 0.001), but did not correlate with SVZ involvement in SCMs (P = 0.193).ConclusionsCompared to SCMs, solitary cerebral astrocytomas exhibited spatial proximity to the SVZ, which might distinguish the supratentorial astrocytomas from SCMs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Differentiation between Solitary Cerebral Metastasis and Astrocytoma on the Basis of Subventricular Zone Involvement on Magnetic Resonance Imaging

Wang

Niu

et al. 2015

PLoS ONE

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“…The hypothesis is based on previous preclinical and clinical research which showed that the SVZ might support the growth of LGG and HGG by providing the tumor with NSCs. 5–7 , 14 , 41 However, it remains controversial, as there is a limited number of previous studies that in contrast report that irradiation of the SVZ decreases OS for patients with HGG. 42–45 A preclinical study by Achanta et al reported a decrease of the proliferating cell marker Ki67 in a mouse model when the SVZ was irradiated, 46 indicating a deteriorated repair capacity.…”

Section: Discussionmentioning

confidence: 99%

Irradiation of the subventricular zone and subgranular zone in high- and low-grade glioma patients: an atlas-based analysis on overall survival

Bruil

Dávid

Nagtegaal

et al. 2022

Neuro-Oncology Advances

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Background Neural stem cells in the subventricular- (SVZ) and subgranular zone (SGZ) are hypothesized to support growth of glioma. Therefore, irradiation of the SVZ and SGZ might reduce tumor growth and might improve overall survival (OS). However, it may also inhibit the repair capacity of brain tissue. The aim of this retrospective cohort study is to assess the impact of SVZ and SGZ radiotherapy doses on OS of patients with high-grade (HGG) or low-grade (LGG) glioma. Methods We included 273 glioma patients who received radiotherapy. We created an SVZ atlas, shared openly with this work, while SGZ labels were taken from the CoBRA atlas. Next, SVZ and SGZ regions were automatically delineated on T1 MR-images. Dose and OS correlations were investigated with Cox regression and Kaplan-Meier analysis. Results Cox regression analyses showed significant hazard ratios for SVZ dose (univariate: 1.029/Gy, p<0.001; multivariate: 1.103/Gy, p = 0.002) and SGZ dose (univariate: 1.023/Gy, p<0.001; multivariate: 1.055/Gy, p<0.001) in HGG patients. Kaplan-Meier analysis showed significant correlations between OS and high/low dose groups for HGG patients (SVZ: respectively 10.7 months (>30.33 Gy) vs 14.0 months (<30.33 Gy) median OS, p = 0.011; SGZ: respectively 10.7 months (>29.11 Gy) vs 15.5 months (<29.11 Gy) median OS, p<0.001). No correlations between dose and OS were found for LGG patients. Conclusion Irradiation doses on neurogenic areas correlate negatively with OS in patients with HGG. Whether sparing of the SVZ and SGZ during radiotherapy improves OS, should be subject of prospective studies.

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“…The hypothesis is based on previous pre-clinical and clinical research which showed that the SVZ might support the growth of LGG and HGG by providing the tumor with NSCs. [5][6][7][8]39 However, it remains controversial, as there is a limited number of previous studies that in contrast report that irradiation of the SVZ decreases OS for patients with HGG. [40][41][42][43] A preclinical study by Achanta et al reported a decrease of the proliferating cell marker Ki67 in a mouse model when the SVZ was irradiated, 44 41,42 Our study describes this negative correlation between SVZ irradiation and OS in HGG patients as well, involving a large number of patients (n = 226).…”

Section: Discussionmentioning

confidence: 99%

Irradiation of the Subventricular Zone and Subgranular Zone: an Atlas-based analysis on Overall Survival in High- and Low-Grade Glioma Patients

Bruil

Dávid

Nagtegaal

et al. 2021

Preprint

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Background: Neural stem cells in the subventricular- (SVZ) and subgranular zone (SGZ) are hypothesized to support growth of glioma. Therefore, irradiation of the SVZ and SGZ might reduce tumor growth and might improve overall survival (OS). However, it may also inhibit the repair capacity of brain tissue. The aim of this retrospective cohort study is to assess the impact of SVZ and SGZ radiotherapy doses on OS of patients with high-grade (HGG) or low-grade (LGG) glioma. Methods: We included 273 glioma patients who received radiotherapy. We created an SVZ atlas, shared openly with this work, while SGZ labels were taken from the CoBRA atlas. Next, SVZ and SGZ regions were automatically delineated on T1 MR-images. Dose and OS correlations were investigated with Cox regression and Kaplan-Meier analysis. Results: Cox regression analyses showed significant hazard ratios for SVZ dose (univariate: 1.029/Gy, p<0.001; multivariate: 1.103/Gy, p = 0.002) and SGZ dose (univariate: 1.023/Gy, p<0.001; multivariate: 1.055/Gy, p<0.001) in HGG patients. Kaplan-Meier analysis showed significant correlations between OS and high/low dose groups for HGG patients (SVZ: respectively 10.7 months (>30.33 Gy) vs 14.0 months (<30.33 Gy) median OS, p = 0.011; SGZ: respectively 10.7 months (>29.11 Gy) vs 15.5 months (<29.11 Gy) median OS, p<0.001). No correlations between dose and OS were not found for LGG patients. Conclusion: Irradiation doses on neurogenic areas correlate negatively with OS in patients with HGG. Whether sparing of the SVZ and SGZ during radiotherapy improves OS, should be subject of prospective studies.

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High-Grade Glioma Relationship to the Neural Stem Cell Compartment: A Retrospective Review of 104 Cases

Cited by 11 publications

References 66 publications

Differentiation between Solitary Cerebral Metastasis and Astrocytoma on the Basis of Subventricular Zone Involvement on Magnetic Resonance Imaging

Differentiation between Solitary Cerebral Metastasis and Astrocytoma on the Basis of Subventricular Zone Involvement on Magnetic Resonance Imaging

Irradiation of the subventricular zone and subgranular zone in high- and low-grade glioma patients: an atlas-based analysis on overall survival

Irradiation of the Subventricular Zone and Subgranular Zone: an Atlas-based analysis on Overall Survival in High- and Low-Grade Glioma Patients

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