2003
DOI: 10.1007/s00428-002-0674-1
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High-grade dysplasia and superficial adenocarcinoma in Barrett's esophagus: histological mapping and expression of p53, p21 and Bcl-2 oncoproteins

Abstract: In order to characterize the early morphological and molecular stages of the neoplastic progression of Barrett's mucosa, we performed the entire histological examination of ten specimens of resected Barrett's esophagus with high-grade dysplasia or superficial adenocarcinoma. The expression of p53, p21 and Bcl-2 proteins was assessed by immunohistochemistry. The surface of Barrett's mucosa ranged from 2.6 cm 2 to 31 cm 2 . Dysplasia and adenocarcinoma always developed in specialized mucosa and often occupied sm… Show more

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Cited by 43 publications
(17 citation statements)
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“…Our study adds to the evidence challenging the notion that metaplastic non-goblet cell CLE is entirely benign, and we would even argue that TFF2 has many advantages as a marker for BE, since it seems to be expressed early in the development of CLE, a lesion we postulate is the primary precursor lesion for EAC. Nevertheless, further studies in patients are needed to clarify the prognostic and diagnostic value of IM and CLE, since at present it remains controversial as to which metaplastic epithelial subtype best defines Barrett’s Esophagus (Chatelain and Flejou, 2003), leading to controversial risk estimates for the development of HGD or EAC in BE patients (Hvid-Jensen et al, 2011). …”
Section: Discussionmentioning
confidence: 99%
“…Our study adds to the evidence challenging the notion that metaplastic non-goblet cell CLE is entirely benign, and we would even argue that TFF2 has many advantages as a marker for BE, since it seems to be expressed early in the development of CLE, a lesion we postulate is the primary precursor lesion for EAC. Nevertheless, further studies in patients are needed to clarify the prognostic and diagnostic value of IM and CLE, since at present it remains controversial as to which metaplastic epithelial subtype best defines Barrett’s Esophagus (Chatelain and Flejou, 2003), leading to controversial risk estimates for the development of HGD or EAC in BE patients (Hvid-Jensen et al, 2011). …”
Section: Discussionmentioning
confidence: 99%
“…These include difficulties in the endoscopic recognition of important lesions, 82 the random nature of esophageal biopsy sampling that is subject to considerable sampling error, 83 and disagreement among pathologists in the histologic interpretation of the esophageal biopsy specimens. 84 Finally, endoscopic examinations are expensive, especially after factoring in costs not only for the endoscopy but also for the tissue acquisition and interpretation.…”
Section: Agai Procedures For Construction Of Technical Reviewsmentioning
confidence: 99%
“…The progression from Barrett's to esophageal cancer occurs through stages of low and high grade dysplasia, which are not visible to the naked eye. Currently, blind four quadrant biopsies are performed at one to two cm intervals, which sample less than five percent of the Barrett's mucosa and are thus open to sampling error 74. This is particularly worrisome as the smallest areas of high grade dysplasia can be no more than a few mm in diameter).…”
Section: Imaging Of Digestive Organsmentioning
confidence: 99%