High grade angiosarcoma of nasal cavity and paranasal sinuses: A rare case with immuno-histopathological study

Deshmukh, Sanjay D; Gaurish, Sinai Khandeparkar Siddhi; Pathak, Netra Aniruddha; Rokade, Vidya; Jadhav, Amruta B

doi:10.4103/0377-4929.168878

Cited by 4 publications

(1 citation statement)

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“…This case also highlights the importance of this lesson. In addition, the risks and challenges associated with operations are also increased due to the tumour location, the relationship between the tumour and other anatomical tissues, and the multifocal nature of the tumour [ 1 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Paranasal sinus angiosarcoma with facial paralysis as a novel manifestation: a case report and literature review

Chai,

Feng,

et al. 2023

BMC Neurol

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Background Paranasal sinus angiosarcoma is an uncommon malignancy, with only a few reported cases worldwide. Although it exhibits multiple symptoms, facial paralysis has not been previously documented as a noticeable presentation. Case Presentation In this case, we report a 40-year-old male who presented with facial numbness and pain for one month, weakness of his facial muscles for 15 days, and recurrent right epistaxis for 1 year. He had a history of nasal inflammatory polyps with chronic sinusitis. Computed tomography and magnetic resonance imaging showed space-occupying lesions in the right nasal cavity and maxillary sinus, with bone destruction occurring in the sinus wall and turbinate. This patient then underwent endoscopic surgery. According to the histopathological and immunohistochemical results, he was eventually diagnosed with paranasal sinus angiosarcoma in April 2021. To date, this patient has not initiated any radiotherapy or chemotherapy and has survived with lymphatic metastasis for at least 3 years. Conclusions This manuscript suggests that paranasal sinus angiosarcoma can present with facial paralysis. Moreover, pathological and immunohistochemical tests are still vital for diagnosing paranasal sinus angiosarcoma and differential diagnosis. Additionally, regular follow-up is crucial for patients with paranasal sinus angiosarcoma, enabling monitoring of recurrence, metastasis, and recovery while contributing valuable clinical data to understanding this rare disease and associated research endeavours.

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Section: Discussionmentioning

confidence: 99%

Paranasal sinus angiosarcoma with facial paralysis as a novel manifestation: a case report and literature review

Chai,

Feng,

et al. 2023

BMC Neurol

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Angiosarcoma arising from nasal cavity; A case report

Kimura,

Yasuda,

Okamoto

et al. 2024

Acta Oto-Laryngologica Case Reports

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Treatment, outcomes, and demographics in sinonasal sarcoma: a systematic review of the literature

Gore

2018

BMC Ear Nose Throat Disord

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BackgroundSarcomas comprise a diverse group of soft tissue mesenchymal malignancies. The sinuses and nasal region are a relatively rare site of sarcomas.MethodsRetrospective review of the literature on sinonasal sarcomas from 1987-2017. Data were analyzed for demographics, treatment type, stage, and histopathologic type. Kaplan-Meier analysis was used to assess and compare survival.ResultsA total of 198 cases of sinonasal sarcoma were identified and analyzed. The median age at diagnosis was 39 years. Overall 5-, 10-, and 20-year survival was 61.3%, 58.9%, and 49.1%, respectively, and disease-free 5-, 10-, and 20-year survival was 53.2%, 49.1%, and 38.3%, respectively. Lymph node metastasis was present at diagnosis in 3.0% of cases, and distant metastasis was present in 3.5% of cases. On univariate analysis T stage, overall stage, treatment type, histopathologic subtype, and presence of distant metastasis significantly affected survival. On multivariate analysis overall stage alone significantly predicted overall survival. Open vs. endoscopic surgery, total radiation dose, and presence of neck metastasis did not significantly affect survival. Combined modality treatment was associated with higher survival rates than single modality therapy.ConclusionsSinonasal sarcoma is a relatively rare malignancy. Lower T and overall stage, lack of distant metastasis, and multimodality therapy were associated with improved survival. Certain histopathologic subtypes were associated with poorer survival.Electronic supplementary materialThe online version of this article (10.1186/s12901-018-0052-5) contains supplementary material, which is available to authorized users.

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High grade angiosarcoma of nasal cavity and paranasal sinuses: A rare case with immuno-histopathological study

Cited by 4 publications

References 1 publication

Paranasal sinus angiosarcoma with facial paralysis as a novel manifestation: a case report and literature review

Paranasal sinus angiosarcoma with facial paralysis as a novel manifestation: a case report and literature review

Angiosarcoma arising from nasal cavity; A case report

Treatment, outcomes, and demographics in sinonasal sarcoma: a systematic review of the literature

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