High grade angiosarcoma fifteen years after breast conservation therapy with radiation therapy: A case report

Boyan, William; Farr, Michael; Georges, Renee N.

doi:10.1016/j.ijscr.2014.11.042

Cited by 2 publications

(3 citation statements)

References 4 publications

(4 reference statements)

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“…Studies not reporting on women with RASB, double publications, and studies reporting on women with primary angiosarcomas were excluded. The 17 identified studies were retrieved in full and cross reference searching was performed and identified 58 further studies reporting on women with RASB [ 5 – 9 , 12 , 29 – 80 ]. Therefore, in summary, 75 studies were analyzed for this review.…”

Section: Literature Reviewmentioning

confidence: 99%

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Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

et al. 2018

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BackgroundRadiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy.Case presentationWe present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor. In August 2016, a bilateral salpingo-oophorectomy was performed to remove a tumor of the left ovary, which was diagnosed as breast cancer recurrence. At the same time, a small, purple skin lesion of 1.2 cm in diameter was noted in the inner upper quadrant of the right breast. RASB was diagnosed by punch biopsy and the tumor was excised with clear margins. Imaging studies showed no evidence of further metastases. A systemic chemotherapy with 6 cycles of liposomal doxorubicin was initiated. Five months later, a local recurrence of RASB was diagnosed and mastectomy was performed. Six months later, the patient is alive with no evidence of disease.Three hundred seven cases of RASB were identified. The pooled incidence rate of RASB was 1/3754 women. The most common treatment of RASB was mastectomy in 83% of cases. Adjuvant radiotherapy or chemotherapy were rarely used with 6 and 4%, respectively, whereas in case of recurrence, chemotherapy was the mainstay of treatment, used in 58% of cases. Radiotherapy and repeated surgery were also common with 30 and 33% of cases, respectively. Overall, the prognosis of women with RASB was poor and the recurrence-free survival was short with a mean of 15.9 months. Mean overall survival was 27.4 months.ConclusionRASB is a rare late complication of breast irradiation. The prognosis of women with RASB is poor. Surgery is the mainstay of treatment for localized disease while systemic chemotherapy and re-irradiation are appropriate for women with disseminated or recurrent RASB.

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Section: Literature Reviewmentioning

confidence: 99%

“…The bulk of studies identified in this systematic review were small case series and case reports [ 7 , 8 , 13 – 44 , 46 – 63 , 65 – 67 , 70 , 72 – 80 ]. As expected, the heterogeneity among these studies with low numbers of RASB patients was considerable.…”

Section: Literature Reviewmentioning

confidence: 99%

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

et al. 2018

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“…Angiosarcoma tend to present 5–6 years, after breast-conserving therapy and subsequent radiotherapy [5] .…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma arising in the non-operated, sclerosing breast after primary irradiation, surviving 6 years post-resection: A case report and review of the Japanese literature

Ito

Tanaka

Suzumura

et al. 2016

International Journal of Surgery Case Reports

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HighlightsThis is the first report of angiosarcoma occurring after radiation on a non-operated breast.The patient underwent mastectomy, surviving disease free for 6 years, despite the generally poor prognosis of angiosarcoma.The potential difficulties of diagnosing angiosarcoma against background fibrosis caused by radiation should be kept in mind.Kaplan-Meier analysis of 60 Japanese breast angiosarcoma patients showed significantly better prognosis in patients with a tumor 2 cm or smaller.

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High grade angiosarcoma fifteen years after breast conservation therapy with radiation therapy: A case report

Abstract: HighlightsWe examine a case of secondary angiosarcoma of the breast fifteen years after original treatment.Introduction into secondary or radiation induced angiosarcoma of the breast.Discussion of the case reports for secondary angiosarcoma of the breast.

Cited by 2 publications

References 4 publications

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

Angiosarcoma arising in the non-operated, sclerosing breast after primary irradiation, surviving 6 years post-resection: A case report and review of the Japanese literature

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