High glucose promotes osteogenic differentiation of human lens epithelial cells through hypoxia‐inducible factor (HIF) activation
Haneen Ababneh,
Enikő Balogh,
Dávid Máté Csiki
et al.
Abstract:Cataract, a leading cause of blindness, is characterised by lens opacification. Type 2 diabetes is associated with a two‐ to fivefold higher prevalence of cataracts. The risk of cataract formation increases with the duration of diabetes and the severity of hyperglycaemia. Hydroxyapatite deposition is present in cataractous lenses that could be the consequence of osteogenic differentiation and calcification of lens epithelial cells (LECs). We hypothesised that hyperglycaemia might promote the osteogenic differe… Show more
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