High glucose microenvironment and human mesenchymal stem cell behavior
Muhammad Abdul Mateen,
Nouralsalhin Alaagib,
Khawaja Husnain Haider
Abstract:High glucose (HG) culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells, analogous to any other cell type in our body. It interferes with diverse signaling pathways, i.e. mammalian target of rapamycin (mTOR)-phosphoinositide 3-kinase (PI3K)-Akt signaling, to impact physiological cellular functions, leading to low cell survival and higher cell apoptosis rates. While elucidating the underlying mechanism responsible for the apoptosis of adipose t… Show more
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