High-gamma oscillations as neurocorrelates of ADHD: A MEG crossover placebo-controlled study

Dor-Ziderman, Yair; Zeev‐Wolf, Maor; Klein, Efrat Hirsch; Bar-Oz, Dor; Nitzan, Uri; Maoz, Hagai; Segev, Aviv; Goldstein, Abraham; Koubi, May; Mendelovic, Shlomo; Gvirts, Hila Z.; Bloch, Yuval

doi:10.1016/j.jpsychires.2021.02.050

Cited by 6 publications

(6 citation statements)

References 54 publications

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“…[37][38][39][40][41][42][43][44][45] We investigated This shows that in ADHD, oscillation dynamics is altered across time scales from seconds to minutes, in addition to the previously found sub-second time scale abnormalities in alpha band for adult, 21,27,29 adolescent 60,61 and child ADHD patients, 30 and in theta- 62 and gamma-bands for adult ADHD. 20 These results are also in line with a recent study reporting intrinsic temporal variability in functional connectivity in ADHD patients 63 and show that aberrant temporal dynamics is also a characteristic of local neuronal processing. ADHD patients had larger alpha band LRTCs in RS compared control group suggestive of longer periods of mind wandering 64,65 In contrast, while in the control group alpha-band LRTCs were suppressed in task compared to RS-activity, this suppression was not evident in ADHD group.…”

Section: Discussionsupporting

confidence: 89%

“…17 At the functional level, evidence for abnormal neuronal dynamics in ADHD patients have been found in electro-(EEG) and magnetoencephalography (MEG). [18][19][20][21] Alpha (8−12 Hz) and beta (13−30 Hz) band oscillations, which are fundamental for attention and topdown control, [21][22][23][24][25][26] show reduced task-dependent suppression and lateralization of local oscillation amplitudes in adults 21,[27][28][29] and children 30 with ADHD. Such aberrant modulation of oscillation amplitudes are thought to arise from decreased structural connectivity (SC) between fronto-parietal (FP) regions.…”

Section: Introductionmentioning

confidence: 99%

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Is mild ADHD beneficial: Brain criticality is maximal with moderate ADHD symptom scores

Hirvonen

Haque

Wang

et al. 2022

Preprint

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Attention-deficit/hyperactivity disorder (ADHD) is characterized by involuntary fluctuations of attention in continuous performance tasks (CPTs) wherein attention must be sustained over long periods of time. The neuronal basis underlying aberrant attentional fluctuations in time scales from seconds to minutes have remained poorly understood. Neuronal alpha- and gamma-band oscillations are thought to implement attentional and top-down control of sensorimotor processing. We hypothesized that aberrant behavioral fluctuations in ADHD would be caused by aberrant endogenous brain dynamics in alpha and gamma-band oscillations and specifically by their aberrant long-range temporal correlations (LRTCs). We measured brain activity with magnetoencephalography (MEG) from adult participants diagnosed with ADHD (N = 19) and from healthy control subjects (N = 20) during resting state and two CPTs; a threshold stimulus detection task and a Go/NoGo task. We then estimated LRTCs of neuronal oscillations and behavioral fluctuations with detrended fluctuation analysis (DFA). ADHD was associated with aberrant LRTCs in both behavioral performance and of neuronal oscillations. LRTCs were correlated with symptom severity with a U-shaped correlations indicating that the LRTCs were largest with moderate symptom scores. These data demonstrate the presence of aberrant temporal dynamics of neuronal oscillations in adult ADHD patients, which may underlie involuntary attentional fluctuations in ADHD. Taken that LRTCs are a hallmark of brain critical dynamics, these data show that moderate ADHD symptoms scores maximize brain criticality which is thought to be beneficial for performance.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Is mild ADHD beneficial: Brain criticality is maximal with moderate ADHD symptom scores

Hirvonen

Haque

Wang

et al. 2022

Preprint

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“…However, the most robust findings of abnormal oscillatory entrainment in ADHD suggest enhanced (rather than attenuated) delta/theta and reduced absolute beta power [59–60], which we did not examine in this study - therefore, we cannot comment further on these possible effects here. There are also reports of atypical resting-state high-gamma oscillations (61-90 Hz) in adults with ADHD compared to controls [61]. Furthermore, absolute gamma power in the range of 35-45 Hz may be associated with ADHD in children [62], although results are not conclusive (for a review of resting-state EEG studies in neuropsychiatric disorders including ADHD, see [60]).…”

Section: Discussionmentioning

confidence: 99%

Bayesian analysis of resting-state temporal low-γ power in children with phonemic decoding deficits and certain comorbidities

Lasnick,

Hancock,

Hoeft

2023

Preprint

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Dyslexia (decoding-based reading disorder, or RD) is a common learning disorder affecting a large proportion of the population. One theory of the origins of reading deficits is a language network which cannot effectively ‘entrain’ to speech, with cascading effects on the development of phonological skills. Low-gamma (low-γ, 30-45 Hz) neural activity is thought to correspond to tracking at phonemic rates in speech. The main goals of the current study were to investigate temporal low-γ band-power during rest in a sample of children and adolescents with and without RD. We used a Bayesian statistical approach, which has become increasingly popular in the field for its ability to quantify the relative likelihood of competing hypotheses. We examined whether (1) resting-state temporal low-γ power was attenuated in the left temporal region in those with RD; (2) low-γ power covaried with individual performance in reading skills; (3) low-γ temporal lateralization was atypical in the group with RD. Results did not support the hypothesized effects of RD status and poor phonemic decoding ability on left hemisphere low-γ power or lateralization: post-hoc tests revealed that the lack of atypicality in the RD group was not due to the inclusion of those with comorbid attentional deficits. However, post-hoc tests also revealed a specific left-dominance for low-γ rhythms in the RDs only when participants with attentional deficits were excluded. We also observed an inverse relationship between phonemic decoding and left-lateralization in the controls, such that those with better decoding skills were less likely to show left-lateralization, contrary to our expectations. We discuss these unexpected findings in the context of prior theoretical frameworks on temporal sampling, and suggest that our null findings in resting-state EEG may reflect the importance of real-time language processing to evoke gamma rhythms in the phonemic range during childhood and adolescence.

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“…However, the most robust findings of abnormal oscillatory entrainment in ADHD suggest enhanced (rather than attenuated) delta/theta and reduced absolute beta power [65,66], which we did not examine in this study-therefore, we cannot comment further on these possible effects here. There are also reports of atypical resting-state high-gamma oscillations (61-90 Hz) in adults with ADHD compared to controls [67]. Furthermore, absolute gamma power in the range of 35-45 Hz may be associated with ADHD in children [68], although results are not conclusive (for a review of resting-state EEG studies in neuropsychiatric disorders including ADHD, see [66]).…”

Section: Plos Onementioning

confidence: 99%

“…In this study we attempted to elucidate an 'average' resting-state gamma profile PLOS ONE derived from both EO and EC data, however future studies would do well to examine both states separately with sufficient data for both cases. There is also a degree of 'fuzziness' or overlap between functional properties ascribed to these different frequency bands: alpha has been reported to be associated with both performance on various intelligence measures and attention [72,73], while higher-range gamma activity has also been proposed to be related to attention [64,67], with alpha-gamma coupling being proposed to reflect early perceptual processing [73][74][75]. These processes are likely to be relevant not just for attention, but for the processing of visual information such as written language.…”

Section: Implications and Limitationsmentioning

confidence: 99%

Left-dominance for resting-state temporal low-gamma power in children with impaired word-decoding and without comorbid ADHD

Lasnick,

Hancock,

Hoeft

2023

PLoS ONE

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One theory of the origins of reading disorders (i.e., dyslexia) is a language network which cannot effectively ‘entrain’ to speech, with cascading effects on the development of phonological skills. Low-gamma (low-γ, 30–45 Hz) neural activity, particularly in the left hemisphere, is thought to correspond to tracking at phonemic rates in speech. The main goals of the current study were to investigate temporal low-γ band-power during rest in a sample of children and adolescents with and without reading disorder (RD). Using a Bayesian statistical approach to analyze the power spectral density of EEG data, we examined whether (1) resting-state temporal low-γ power was attenuated in the left temporal region in RD; (2) low-γ power covaried with individual reading performance; (3) low-γ temporal lateralization was atypical in RD. Contrary to our expectations, results did not support the hypothesized effects of RD status and poor decoding ability on left hemisphere low-γ power or lateralization: post-hoc tests revealed that the lack of atypicality in the RD group was not due to the inclusion of those with comorbid attentional deficits. However, post-hoc tests also revealed a specific left-dominance for low-γ rhythms in children with reading deficits only, when participants with comorbid attentional deficits were excluded. We also observed an inverse relationship between decoding and left-lateralization in the controls, such that those with better decoding skills were less likely to show left-lateralization. We discuss these unexpected findings in the context of prior theoretical frameworks on temporal sampling. These results may reflect the importance of real-time language processing to evoke gamma rhythms in the phonemic range during childhood and adolescence.

show abstract

High-gamma oscillations as neurocorrelates of ADHD: A MEG crossover placebo-controlled study

Cited by 6 publications

References 54 publications

Is mild ADHD beneficial: Brain criticality is maximal with moderate ADHD symptom scores

Is mild ADHD beneficial: Brain criticality is maximal with moderate ADHD symptom scores

Bayesian analysis of resting-state temporal low-γ power in children with phonemic decoding deficits and certain comorbidities

Left-dominance for resting-state temporal low-gamma power in children with impaired word-decoding and without comorbid ADHD

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