High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

Ma, Richard; Xia, Xinzhao; Zhang, Wei; Lu, Zhuo; Wu, Qianying; Cui, Jiangtian; Song, Hongwen; Fan, Chuan; Chen, Xueli; Wei, Junjie; Ji, Gong‐Jun; Wang, Kai; Wang, Xiaoxiao; Qiu, Bensheng; Zhang, Xiaochu

doi:10.1101/2021.03.26.437107

Cited by 3 publications

(3 citation statements)

References 80 publications

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“…Currently, tES strategies lead to undesirable sensations of stimulation that hinder wider applications. Many tES studies are now focusing on temporal interference stimulation, which seems to be almost imperceptible to healthy subjects ( Ma et al, 2021 ). Future studies might adopt this strategy to avoid unblinding of patients in double-blind studies, providing more pleasant stimulation experience for patients.…”

Section: Discussionmentioning

confidence: 99%

Novel Non-invasive Transcranial Electrical Stimulation for Parkinson’s Disease

Yuan

et al. 2022

Front. Aging Neurosci.

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Conventional transcranial electrical stimulation (tES) is a non-invasive method to modulate brain activity and has been extensively used in the treatment of Parkinson’s disease (PD). Despite promising prospects, the efficacy of conventional tES in PD treatment is highly variable across different studies. Therefore, many have tried to optimize tES for an improved therapeutic efficacy by developing novel tES intervention strategies. Until now, these novel clinical interventions have not been discussed or reviewed in the context of PD therapy. In this review, we focused on the efficacy of these novel strategies in PD mitigation, classified them into three categories based on their distinct technical approach to circumvent conventional tES problems. The first category has novel stimulation modes to target different modulating mechanisms, expanding the rang of stimulation choices hence enabling the ability to modulate complex brain circuit or functional networks. The second category applies tES as a supplementary intervention for PD hence amplifies neurological or behavioral improvements. Lastly, the closed loop tES stimulation can provide self-adaptive individualized stimulation, which enables a more specialized intervention. In summary, these novel tES have validated potential in both alleviating PD symptoms and improving understanding of the pathophysiological mechanisms of PD. However, to assure wide clinical used of tES therapy for PD patients, further large-scale trials are required.

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Section: Discussionmentioning

confidence: 99%

Novel Non-invasive Transcranial Electrical Stimulation for Parkinson’s Disease

Yuan

et al. 2022

Front. Aging Neurosci.

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“…For example, most studies used the duration of 15 min to 20 min, and the polar plate is mostly 25 cm 2 . Previous works utilized commonly used valence motor skills learning tasks, including SRTT, SFTT and SVIPT (Ma et al, 2021 ). However, when these indicators were applied to evaluate motor skills learning, the task evaluation setting was relatively simple and ignored multidimensional and complex motor skills.…”

Section: Discussionmentioning

confidence: 99%

Effects of transcranial direct current stimulation on motor skills learning in healthy adults through the activation of different brain regions: A systematic review

Zhiqiang²,

Wei³

et al. 2022

Front. Hum. Neurosci.

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ObjectiveThis systematic review aims to analyze existing literature of the effects of transcranial direct current stimulation (tDCS) on motor skills learning of healthy adults and discuss the underlying neurophysiological mechanism that influences motor skills learning.MethodsThis systematic review has followed the recommendations of the Preferred Reporting Items for Systematic reviews and Meta-Analyses. The PubMed, EBSCO, and Web of Science databases were systematically searched for relevant studies that were published from database inception to May 2022. Studies were included based on the Participants, Intervention, Comparison, Outcomes, and Setting inclusion strategy. The risk of bias was evaluated by using the Review manager 5.4 tool. The quality of each study was assessed with the Physiotherapy Evidence Database (PEDro) scale.ResultsThe electronic search produced 142 studies. Only 11 studies were included after filtering. These studies performed well in terms of distribution, blinding availability and selective reporting. They reported that tDCS significantly improved motor skills learning. The main outcomes measure were the improvement of the motor sequence tasks and specific motor skills. Nine studies showed that tDCS interventions reduced reaction time to complete motor sequence tasks in healthy adults and two studies showed that tDCS interventions improved golf putting task performance.ConclusionThe included studies showed that tDCS can help healthy adults to improve the motor skills learning by activating different brain regions, such as the primary motor cortex, left dorsolateral prefrontal cortex and right cerebellum. However, the number of included studies was limited, and the sample sizes were small. Therefore, more studies are urgently needed to validate the results of current studies and further explore the underlying neurophysiological mechanisms of tDCS in the future.

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“…For example, most studies used the duration of 15 min to 20 min, and the polar plate is mostly 25 cm 2 . Previous works utilized commonly used valence motor skills learning tasks, including SRTT, SFTT and SVIPT (Ma et al, 2021). However, when these indicators were applied to evaluate motor skills learning, the task evaluation setting was relatively simple and ignored multidimensional and complex motor skills.…”

Section: Influences Of DI Erent Brain Regions On Tdcs-induced Motor S...mentioning

confidence: 99%

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High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

Cited by 3 publications

References 80 publications

Novel Non-invasive Transcranial Electrical Stimulation for Parkinson’s Disease

Novel Non-invasive Transcranial Electrical Stimulation for Parkinson’s Disease

Effects of transcranial direct current stimulation on motor skills learning in healthy adults through the activation of different brain regions: A systematic review

Table_1.xlsx

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