High-fructose drinks affect microRNAs expression differently in lean and obese mice

Hanousková, Barbora; Neprašová, Barbora; Skálová, Lenka; Maletı́nská, Lenka; K, Zemanová; Ambrož, Martin; Matoušková, Petra

doi:10.1016/j.jnutbio.2019.03.001

Cited by 19 publications

(17 citation statements)

References 55 publications

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“…Previously, this was shown also in a mouse model of CRC for miR-145 and miR-33a [120]. Moreover, miR-145 was described to be upregulated in the liver of both genetic and diet-induced obese mice [49], and miR-33a was decreased in white adipose tissue [39], and when knocked out, predisposed mice to obesity and IR [121]. These findings suggested that both miRNAs were related with obesity, IR, and cancer.…”

Section: Micrornas Linking Obesity To Colorectal Cancer (Crc)mentioning

confidence: 82%

“…In mice with obesity induced by a high-fat diet, miR-21 has been described to be overexpressed in epididymal fat and associated with an increased number of adipocytes and of signal transducer and activator of transcription 3 (STAT3), a key protein that responds to cytokines and growth factors [37], whereas if knocked-down, reduced weight and adipocyte size were observed [38]. Furthermore, it was found increased in plasma from obese and lean mice fed with a high-fructose diet [39].…”

Section: Mirnas In Obesitymentioning

confidence: 99%

“…MiR-27a was described downregulated in mature adipocytes from obese mice with respect to lean mice, suppressing adipocyte differentiation. MiR-27a is also known to target peroxisome proliferator activated receptor gamma (PPARγ) [41], and interestingly, it is also upregulated in the liver of obese and lean mice on a high-fructose diet [39], in genetically obese mice, as well as in epididymal fat tissue [42].…”

Section: Mirnas In Obesitymentioning

confidence: 99%

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Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role?

Cirillo

Catellani

Sartori

et al. 2019

IJMS

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Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs (miRNAs), which post-transcriptionally regulate gene expression. Dysregulated miRNA profiles have been associated with diseases including obesity and cancer. Herein we report dysregulated miRNAs in obesity both in animal models and in humans, and we also document dysregulated miRNAs in colorectal cancer (CRC), as example of an obesity-related cancer. Some of the described miRNAs are found to be similarly dysregulated both in obesity, insulin resistance (IR), and CRC. Thus, we present miRNAs as a potential molecular link between obesity and CRC onset and development, giving a new perspective on the role of miRNAs in obesity-associated cancers.

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Section: Micrornas Linking Obesity To Colorectal Cancer (Crc)mentioning

confidence: 82%

Section: Mirnas In Obesitymentioning

confidence: 99%

Section: Mirnas In Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role?

Cirillo

Catellani

Sartori

et al. 2019

IJMS

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“…In addition, high glucose-stimulated expression of miR-21 inactivates PRAS40, a negative regulator of mTORC1 [ 60 ]. Fructose can also increase plasma levels of miR-21 [ 256 ].…”

Section: Environmental Factors Upregulating Mir-21mentioning

confidence: 99%

“…High-fat diet-induced obesity Increase of circulatory and adipocyte miR-21 [230,231] High glucose intake Increase of circulatory miR-21 [60] High fructose intake Increase of circulatory miR-21 [256] Alcohol consumption Increase of circulatory miR-21 [276,277] Milk consumption Increase of circulatory exosomal miR-21 [210][211][212][213] Vitamin D deficiency Increased expression of miR-21 [95] Smoking Increased expression of exosomal miR-21 in airway epithelial cells [287][288][289] Air pollution (Diesel) Increased expression of exosomal miR-21 in airway epithelial cells [290] Sedentary lifestyle Increase of circulatory miR-21 [334,335] Aging Increase of circulatory miR-21 [324,325] Chronic inflammation Increase of circulatory miR-21 [331][332][333] 6. Therapeutic Suppression of MiR-21…”

Section: Lifestyle Factor Biological Responses Referencesmentioning

confidence: 99%

MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors

Melnik

John

Carrera-Bastos

et al. 2020

Cancers

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DNA mutation-induced activation of RAS-BRAF-MEK-ERK signaling associated with intermittent or chronic ultraviolet (UV) irradiation cannot exclusively explain the excessive increase of malignant melanoma (MM) incidence since the 1950s. Malignant conversion of a melanocyte to an MM cell and metastatic MM is associated with a steady increase in microRNA-21 (miR-21). At the epigenetic level, miR-21 inhibits key tumor suppressors of the RAS-BRAF signaling pathway enhancing proliferation and MM progression. Increased MM cell levels of miR-21 either result from endogenous upregulation of melanocytic miR-21 expression or by uptake of miR-21-enriched exogenous exosomes. Based on epidemiological data and translational evidence, this review provides deeper insights into environmentally and metabolically induced exosomal miR-21 trafficking beyond UV-irradiation in melanomagenesis and MM progression. Sources of miR-21-enriched exosomes include UV-irradiated keratinocytes, adipocyte-derived exosomes in obesity, airway epithelium-derived exosomes generated by smoking and pollution, diet-related exosomes and inflammation-induced exosomes, which may synergistically increase the exosomal miR-21 burden of the melanocyte, the transformed MM cell and its tumor environment. Several therapeutic agents that suppress MM cell growth and proliferation attenuate miR-21 expression. These include miR-21 antagonists, metformin, kinase inhibitors, beta-blockers, vitamin D, and plant-derived bioactive compounds, which may represent new options for the prevention and treatment of MM.

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Pathobiological and molecular connections involved in the high fructose and high fat diet induced diabetes associated nonalcoholic fatty liver disease

et al. 2020

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High-fructose drinks affect microRNAs expression differently in lean and obese mice

Cited by 19 publications

References 55 publications

Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role?

Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role?

MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors

Pathobiological and molecular connections involved in the high fructose and high fat diet induced diabetes associated nonalcoholic fatty liver disease

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