High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke

Harrell, Constance S.; Zainaldin, C.; McFarlane, D.; Hyer, Molly M.; Stein, Donald G.; Sayeed, Iqbal; Neigh, Gretchen N.

doi:10.1016/j.bbi.2018.05.018

Cited by 30 publications

(18 citation statements)

References 69 publications

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“…This may be explained by the fact that the MEDAS questionnaire does not discriminate between types of fruits consumed. Studies have confirmed that eating an apple a day has positive effects on mood [ 89 ], but other fruits having high levels of fructose have depressive effects on both animal models [ 90 ] and human models [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Adherence to the Mediterranean Diet, Intake of Specific Foods and Depression in an Adult Population (45–75 Years) in Primary Health Care. A Cross-Sectional Descriptive Study

et al. 2021

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Background: The relationship between the quality of the diet and the adherence to the Mediterranean diet with the presence of persistent or recurrent depressive symptoms have been described. The objective of this study is to analyze the relationship between adherence to the Mediterranean diet and the intake of specific foods in primary care patients aged 45 to 75, having subclinical or major depression. The study also specifically analyzes this relationship in individuals suffering from chronic diseases. Methods: A cross-sectional descriptive study was conducted. 3062 subjects met the inclusion criteria from the EIRA study. Sociodemographic variables, clinical morbidity, depression symptomatology (PHQ-9) and adherence to Mediterranean diet (MEDAS) were collected. Results: Being female, younger, with a higher BMI, consuming more than 1 serving of red meat a day and drinking more than one carbonated or sugary drink daily, not consuming 3 servings of nuts a week and not eating 2 vegetables cooked in olive oil a week are predictors of having higher depressive symptomatology. Conclusions: Assessing the type of diet of patients presenting depressive symptoms and promoting adherence to a healthy diet is important, especially in patients with chronic diseases. However, depression is a very complex issue and the relationship between nutrition and depression must be further examined.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Adherence to the Mediterranean Diet, Intake of Specific Foods and Depression in an Adult Population (45–75 Years) in Primary Health Care. A Cross-Sectional Descriptive Study

et al. 2021

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“…Consistent with previous work in Wistar rats [24,28], we used a HFrD to induce metabolic challenge in Sprague Dawley rats. Sprague Dawley rats were randomly assigned to either a "control" diet (Lab Rodent Diet 5001, 0.30% kcal from fructose) or a HFrD (Research Diets D05111802, 55% kcal from fructose).…”

Section: Dietmentioning

confidence: 98%

High-fructose diet initiated during adolescence does not affect basolateral amygdala excitability or affective-like behavior in Sprague Dawley rats

O'Flaherty

Neigh

Rainnie

2019

Behavioural Brain Research

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Patients with type-2 diabetes, obesity, and metabolic syndrome have a significantly increased risk of developing depression. Dysregulated metabolism may contribute to the etiology of depression by affecting neuronal activity in key limbic areas. The basolateral amygdala (BLA) acts as a critical emotional valence detector in the brain's limbic circuit, and shows hyperactivity and abnormal glucose metabolism in depressed patients. Furthermore, administering a periadolescent high-fructose diet (HFrD; a model of metabolic syndrome) to male Wistar rats increases anxietyand depressive-like behavior. Repeated shock stress in Sprague Dawley rats similarly increases anxiety-like behavior and increases BLA excitability. We therefore investigated whether a metabolic stressor (HFrD) would have similar effects as shock stress on BLA excitability in Sprague Dawley rats. We found that a HFrD did not affect the intrinsic excitability of BLA neurons. Fructose-fed Sprague Dawley rats had elevated body fat mass, but did not show increases in metabolic efficiency and fasting blood glucose relative to control. Finally unlike Wistar rats, fructose-fed Sprague Dawley rats did not show increased anxiety-and depressive-like behavior. These results suggest that genetic differences between rat strains may affect susceptibility to a metabolic insult. Collectively, these data show that a periadolescent HFrD disrupts metabolism, but does not change affective behavior or BLA excitability in Sprague Dawley rats.

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“…behaviour (31) . Thus, these associations between total DF intake and prevalence of depressive symptoms could be affected by fructose.…”

Section: Discussionmentioning

confidence: 99%

Associations between different types and sources of dietary fibre intake and depressive symptoms in a general population of adults: a cross-sectional study

et al. 2020

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This cross-sectional study aimed to examine the associations between dietary fibers (DF) intake and depressive symptoms in a general adult population in Tianjin, China. A total of 24,306 participants (mean age, 41 years; range 18-91 years) were enrolled. DF intake was assessed using a validated self-administered food frequency questionnaire. Depressive symptoms were assessed using the Self-Rating Depression Scale. Associations between DF intake and depressive symptoms were estimated using logistic regression analysis. Socio-demographic, behavioral, health status, and dietary factors were adjusted. In men, compared to participants in the lowest quartiles for total, soluble, vegetable, and soy DF, odds ratios (ORs; 95% confidence intervals [CIs]) for depressive symptoms in the highest were 0.83 (0.69, 0.99), 0.74 (0.63, 0.87), 0.79 (0.65, 0.96), and 0.69 (0.60, 0.81), respectively. In women, compared to participants in the lowest quartiles for vegetable and soy DF, the ORs (95% CIs) for depressive symptoms in the highest were 0.77 (0.64, 0.93) and 0.82 (0.70, 0.95), respectively. No association was found between total or soluble DF intake and depressive symptoms in women. No association was found between insoluble, cereal, fruit, or tuber DF intake and depressive symptoms in men and women. Linear associations between DF intake and depressive symptoms were only detected for soy foods DF (men, β = -0.148, P < 0.0001; women, β = -0.069, P = 0.04). Results suggest intake of soluble, vegetable, and soy DF were inversely associated with depressive symptoms. These results should be confirmed through prospective and interventional studies.

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High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke

Cited by 30 publications

References 69 publications

The Relationship between Adherence to the Mediterranean Diet, Intake of Specific Foods and Depression in an Adult Population (45–75 Years) in Primary Health Care. A Cross-Sectional Descriptive Study

The Relationship between Adherence to the Mediterranean Diet, Intake of Specific Foods and Depression in an Adult Population (45–75 Years) in Primary Health Care. A Cross-Sectional Descriptive Study

High-fructose diet initiated during adolescence does not affect basolateral amygdala excitability or affective-like behavior in Sprague Dawley rats

Associations between different types and sources of dietary fibre intake and depressive symptoms in a general population of adults: a cross-sectional study

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