2015
DOI: 10.1186/s12986-015-0024-3
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High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits

Abstract: BackgroundIndividuals with insulin resistance and resulting impaired glucose tolerance along with type 2 diabetes showed an increased prevalence of atherosclerosis. Our aim in this study was to address whether diet-induced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits.MethodsWe fed Watanabe heritable hyperlipidemic (WHHL) rabbits with a high-fructose and high-fat diet (HFFD) with restricted normal calories and compared the lesions of both… Show more

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Cited by 43 publications
(53 citation statements)
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“…The HFD group was fed a chow diet supplemented with 10% coconut oil1015. The HFD was rich in fat, but with relatively less protein and fiber.…”
Section: Discussionmentioning
confidence: 99%
“…The HFD group was fed a chow diet supplemented with 10% coconut oil1015. The HFD was rich in fat, but with relatively less protein and fiber.…”
Section: Discussionmentioning
confidence: 99%
“…Obesity resulted in markedly increased serum creatinine kinase MB levels, a biomarker of cardiac tissue injury [7] . Exposing WHHL rabbits for 16 weeks to a HFFD versus a control diet however, did not affect body weight, but did lead to more SC and visceral fat accumulation, higher plasma and hepatic triglyceride levels, impaired glucose tolerance and accelerated aortic and coronary atherosclerosis [5] . In this study, we exposed WHHL-MI rabbits for one year to this HFD to slowly induce obesity, and to investigate whether these pathological conditions would enhance atherogenesis and affect cardiac function, leading to an accelerated mortality.…”
Section: Cardiac Function and Myocardial Fibrosismentioning
confidence: 87%
“…17-to 21-months old rabbits showed higher accumulation of RAM-11 (macrophages/monocytes)-positive mesenteric (MES) AT and lower plasma insulin levels as compared to adult WHHLMI rabbits [4] . 16 weeks exposure of WHHL rabbits to a high-fat and high-fructose diet (HFFD) induced an elevation of plasma lipid levels, impaired glucose tolerance, accumulation of AT and accelerated coronary atherosclerosis in these animals [5] .…”
Section: Introductionmentioning
confidence: 99%
“…Thus, dysregulation of insulin signaling in VSMCs at the level of insulin receptor and IRS-2 may result in proliferative and proapoptotic phenotypes, which would enhance and exacerbate atherosclerosis, respectively. Although high fructose consumption is known to induce insulin resistance and promote atherosclerosis (D’Angelo et al, 2005; Lu et al, 2013; Ning et al, 2015), it is unknown as to how fructose uptake in VSMCs regulates insulin receptor signaling and proliferative phenotype.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, high fructose diet-induced insulin resistance results in exaggerated atherosclerosis and neointima formation with a significant increase in smooth muscle cell accumulation (Lu et al, 2013; Ning et al, 2015). Since platelet-derived growth factor (PDGF) is a potent mitogen released at the site of arterial injury (Barrett and Benditt, 1987; Heldin and Westermark, 1999; Rubin et al, 1988), it is likely that high fructose-induced increase in neointima formation may occur through enhanced PDGF receptor signaling.…”
Section: Introductionmentioning
confidence: 99%