High-frequency ultrasound detection and follow-up of Wilms’ tumor in the mouse

Ultrasonic Assessment of Hepatic Blood Flow as a Marker of Mouse Hepatocarcinoma

“…Vascular development can also be assessed with high-frequency Doppler imaging, which permits detection and characterization of ocular blood flow . With UBM, Cheung (2005) followed the early tumor growth in mice bearing melanoma xenograft in a longitudinal assay, and Jouannot (2006) followed early detection and tumor growth in a murine Wilms' tumor model. UBM with 15-MHz frequency imaging and high-resolution color Doppler echocardiography was used to recognize functional and morphologic modifications as a result of coronary atherosclerosis in living mouse tissue (Wikström 2005).…”

In Vivo mouse imaging and spectroscopy in drug discovery

“…Ultrasound techniques have also been shown to be very useful in murine cancer research (38)(39)(40)(41)(42)(43)(44). Highfrequency UBM has been used for the quantitative analysis of early tumor growth in mice bearing melanoma xenografts (38).…”

“…Highfrequency UBM has been used for the quantitative analysis of early tumor growth in mice bearing melanoma xenografts (38). The feasibility of UBM for early detection and characterization of renal tumor development was recently demonstrated by Jouannot et al (39), with a relative r.m.s. error between ultrasonic and histological evaluations of maximum cross-sectional area lower than 20%.…”

The Use of Preclinical Models to Improve the Treatment of Retinoblastoma

“…In addition the histological process often involves several dehydration steps that could alter the volume of the eye when compared to in vivo images. This had been commonly seen by researchers who compared ultrasound volume measurements of the kidney to histological sections [145]. Again, one would expect the ratio to correct these differences, but it is important to consider that the tissue shrinkage for the eye could be different for tumor tissue compared to normal tissue.…”

“…This is due to translational limitations, such as the late development of mouse models and the inability to follow tumors in real time with diagnostic tools. The ability to non-invasively follow tumor development in preclinical models amount other fields, including pediatric renal tube malignancies, neuroblastoma and prostate cancer, has become the standard method in testing new therapies [143][144][145]. Until recently, similar modalities, tonometer, optomotry, retina camera, ultrasound and MRI, were not readily available to monitor tumor progression in retinoblastoma mice.…”