High‐frequency ultrasonography—New non‐invasive method in assessment of skin lymphomas

Abstract

We present for the first time the possibility of monitoring patients' clinical state on the base of non-invasive USG imaging. We recommend additional use of 20 MHz USG to reduce intra-observer variability and to assess residual disease. USG imaging can complement evaluation of skin lesions in MF and can support clinical judgement.

High‐frequency ultrasonography a new quantitative method in evaluation of skin lymphomas—First comparative study in relation to histopathology

“…Our previous studies revealed that in MF we can monitor patients’ response to different modalities on the base of the change of the mean SLEB value and that SLEB is related to the severity of the disease . After completion of UV therapy in all subjects, SLEB decreased or disappeared completely what was related to clinical evaluation .…”

“…Our previous studies revealed that in MF we can monitor patients’ response to different modalities on the base of the change of the mean SLEB value and that SLEB is related to the severity of the disease . After completion of UV therapy in all subjects, SLEB decreased or disappeared completely what was related to clinical evaluation . We speculated that SLEB probably reflects the infiltration with clonal T cells of the upper parts of the dermis and its thinning or even complete disappearance may be observed after successful treatment and may serve as a useful indicator of effectiveness of therapy.…”

“…Different types of skin lesion present different prognosis, while the classification of lesional skin into patch (flat lesion) or plaque (elevated lesion) seems to be subjective and may be associated with significant risk of disagreement . 20‐MHZ USG has been previously reported in our study to be useful in the evaluation of MF with a possibility of monitoring the effects of therapies . The uniform USG feature of infiltrative MF is the presence of linear low echogenic band underneath entrance echo (subepidermal low echogenic band, SLEB), which width may vary between different skin lesions and severity of the disease .…”

“…10 20-MHZ USG has been previously reported in our study to be useful in the evaluation of MF with a possibility of monitoring the effects of therapies. 11,12 The uniform USG feature of infiltrative MF is the presence of linear low echogenic band underneath entrance echo (subepidermal low echogenic band, SLEB), which width may vary between different skin lesions and severity of the disease. 11,12 The relation between SLEB and infiltration with clonal T cells is presumptive.…”

Rosacea‐like cutaneous localization of small lymphocytic lymphoma unmasked by high‐frequency‐ultrasound

“…Recently, ultrasound was proposed to monitor the response to therapy in mycosis fungoides. 9 In conclusion, our case underlines the importance of this ancillary tool also in a superficial specialty such dermatology is, because it could avoid unnecessary biopsy or may suggest to perform a diagnostic biopsy as in this condition.…”