High Frequency Ultrasonic Imaging

Shung, K. Kirk

doi:10.1016/s0929-6441(09)60012-6

Cited by 132 publications

(71 citation statements)

References 16 publications

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“…High-frequency ultrasound (>30 MHz) has been widely used in small-animal studies because of its excellent spatial resolution (<100 μm) [23]. The other major advancement in diagnostic ultrasound (i.e., at <20 MHz) is clinical applications of SWEI, including for breast, vascular, and liver diseases [24]- [27].…”

Section: Discussionmentioning

confidence: 99%

Shear-wave elasticity imaging of a liver fibrosis mouse model using high-frequency ultrasound

Yeh

Chen

Tseng³

et al. 2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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The objective of this study was to develop a high-frequency imaging platform for evaluating liver fibrosis in mice based on shear-wave elasticity imaging (SWEI). Although SWEI has been used to diagnose hepatic fibrosis clinically, it is performed at relatively low frequencies (<20 MHz). For preclinical ultrasound imaging in small animals, a high-frequency (>30 MHz) single-element transducer with mechanical scanning is often used. In this study we developed a new SWEI system based on a 40-MHz single-element transducer for imaging and a separate 20-MHz excitation transducer for producing the radiation force and the associated shear waves. Liver fibrosis was induced in ten C57BL/6 (B6) mice using carbon tetrachloride; the other ten mice served as the control group. Synchronizing the excitation beam (i.e., the beam from the excitation transducer) and the detection beam sequence (i.e., the beam from the imaging transducer) allows this mechanical-scanning setup to analyze the shear-wave dispersion relation. The liver viscoelastic properties were determined in vivo by measuring the shear-wave dispersion curve followed by fitting to the Voigt model. The mice were then killed and the fibrosis stage was evaluated (from F0 to F4) based on the METAVIR score. The measured mean values of liver elasticity and viscosity, respectively, ranged from 1.06 to 1.89 kPa and from 1.29 to 1.75 Pa∙s for normal F0 and fibrosis stages of F3 and F4. The Spearman coefficients for the correlations between the measured elasticity and viscosity at various fibrosis stages as assessed by the METAVIR score were 0.73 (p < 0.001) and 0.634 (p = 0.0013), respectively. We also found that the collagen content in the liver was linearly correlated with the measured elasticity (r(2) = 0.54, p < 0.001) and less strongly with the viscosity (r2 = 0.26, p = 0.022). Finally, the diagnosis performance of high-frequency SWEI was evaluated using multivariate receiver operating characteristic curve (ROC) analysis. The areas under the multivariate ROC curve for diagnosing fibrosis stages of F ≥ 3, F = 4, F0 vs. F3, F0 vs. F4, and F3 vs. F4 were 0.9, 0.98, 0.83, 1.0, and 0.96, respectively. Compared with traditional ROC analysis, an improved diagnosis performance was found for diagnosing fibrosis stages of F ≥ 3 and F0 vs. F3. These results demonstrate that the developed high-frequency SWEI platform can yield quantitative viscoelastic properties for diagnosing various fibrosis stages in mice. It is a promising tool for studying the progression of liver fibrosis in preclinical animal models both noninvasively and quantitatively.

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Section: Discussionmentioning

confidence: 99%

Shear-wave elasticity imaging of a liver fibrosis mouse model using high-frequency ultrasound

Yeh

Chen

Tseng³

et al. 2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…40-60-MHz clinical ultrasound systems, with high resolution on the order of 20 to 100 micron, are being developed with applications in ophthalmology, oncology, intravascular ultrasound, dermatology, and rheumatology. However, resolution comes at the expense of a shallower depth of penetrationof about 8-9 mm [31].…”

Section: Ultrasound Backscatter Microscopy (Ultrasound Biomicroscopy)mentioning

confidence: 99%

The Evolution of Ultrasound Technologies; from Anatomic to Physiologic,Histologic, and Molecular Imaging

Monsky¹

2013

Anat Physiol

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“…Traditionally, hydrophones used to characterize the ultrasound fields with a known frequency response up to 40 MHz was deemed sufficient [3]. However, recent advancements in high frequency applications of ultrasound in diagnosis [4] and the use of high intensity ultrasound for therapy [5] demands hydrophone responses be known to frequencies as high as 100 MHz for accurate characterization of the field.…”

Section: Introductionmentioning

confidence: 99%

Laser generated ultrasound sources using polymer nanocomposites for high frequency metrology

Rajagopal

Sainsbury

Treeby

et al. 2017

2017 IEEE International Ultrasonics Symposium (IUS)

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Abstract-Accurate characterization of ultrasound fields generated by diagnostic and therapeutic transducers is critical for patient safety. This requires hydrophones calibrated to a traceable standard and currently the upper calibration frequency range available to the user community is limited to a frequency of 40 MHz. However, the increasing use of high frequencies for both imaging and therapy necessitates calibrations to frequencies well beyond this range. For this to be possible, a source of high amplitude, broadband, quasi-planar and stable ultrasound fields is required. This is difficult to achieve using conventional piezoelectric sources, but laser generated ultrasound is a promising technique in this regard. In this study, various polymer-carbon nanotube nanocomposites (PNC) were fabricated and tested for their suitability for such an application by varying the polymer type, carbon nanotubes weight content in the polymer, and PNC thickness. A broadband hydrophone was used to measure the peak pressure and bandwidth of the laser generated ultrasound pulse. Peak-positive pressures of up to 8 MPa and −6dB bandwidths of up to 40 MHz were recorded. There is a nonlinear dependence of the peak pressure on the laser fluence and the bandwidth scales inversely proportionally to the peak pressure. The high-pressure plane waves generated from this preliminary investigation has demonstrated that laser generated ultrasound sources are a promising technique for high frequency calibration of hydrophones.

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High Frequency Ultrasonic Imaging

Cited by 132 publications

References 16 publications

Shear-wave elasticity imaging of a liver fibrosis mouse model using high-frequency ultrasound

Shear-wave elasticity imaging of a liver fibrosis mouse model using high-frequency ultrasound

The Evolution of Ultrasound Technologies; from Anatomic to Physiologic,Histologic, and Molecular Imaging

Laser generated ultrasound sources using polymer nanocomposites for high frequency metrology

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