High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction

Feng, Zhouyan; Wang, Zhaoxiang; Guo, Zheshan; Zhou, Wenjie; Cai, Ziyan; Durand, Dominique M.

doi:10.1016/j.brainres.2017.02.008

Cited by 32 publications

(52 citation statements)

References 42 publications

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“…These HFS-induced activations can propagate along axons to finally activate downstream post-synaptic neurons. They may then modulate neuronal firing in a de-synchronized manner (Feng et al, 2017;Wang et al, 2018), thereby eliminating theta rhythms.…”

Section: Discussionmentioning

confidence: 99%

“…Four neighboring channels of the recording array located in the pyramidal layer were used to extract the unit spikes of neuronal firing as described previously (Feng et al, 2017). Briefly, HFS stimulation artifacts were removed by a linear interpolation algorithm (Yu et al, 2016): a signal segment of 1.5 ms around each artifact of a stimulation pulse was replaced by a short linear interpolation that connected the two endpoints of the artifact segment.…”

Section: Analysis Of Single Unit Spikesmentioning

confidence: 99%

“…According to the waveform features of spikes of interneurons and pyramidal neurons, single unit spikes of different neurons were distinguished (Feng et al, 2017). Briefly, half widths (measured from the negative peak to the post-positive peak) of the mean spike waveforms of different neurons were evaluated.…”

Section: Analysis Of Single Unit Spikesmentioning

confidence: 99%

“…2A). The two minute period immediately following HFS was skipped because the firing of unit spikes would stop for tens of seconds and then gradually recove during this period (Feng et al, 2017).…”

Section: Hfs Changed the Rhythms In Neuronal Firingmentioning

confidence: 99%

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High-frequency stimulation of afferent axons alters firing rhythms of downstream neurons

Feng

Wang

et al. 2019

J. Integr. Neurosci.

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J o u r n a l o f I n t e g r a t i v e N e u r o s c i e n c eThis is an open access article under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by-nc/4.0/) Deep brain stimulation is an emerging treatment for brain disorders. However, the mechanisms of high-frequency brain stimulation are unclear. Recent studies have suggested that high-frequency stimulation might produce therapeutic effects by eliminating pathological rhythms in neuronal firing. To test the hypothesis, the present study investigated whether stimulation of axonal afferent fibers might alter firing rhythms of downstream neurons in invivo experiments with Sprague-Dawley rats. Stimulation trains of 100 Hz with one minute duration were applied to the Schaffer collaterals of hippocampus Area CA1 in anaesthetized rats. Spikes of single interneurons and pyramidal neurons in the downstream region were analyzed. The spike rhythms before, during, and after the stimulations were evaluated by analyzing the power spectrum density of autocorrelograms of the spiking sequences. The rhythms of local field potentials were also evaluated by power spectrum density. During baseline recordings, theta rhythms were obvious in the spiking sequences of both types of neuron and in the local field potentials of the stratum radiatum. However, these theta rhythms were all suppressed significantly during the stimulations. Additionally, the results of Pearson's correlation analysis showed that 20-30% variation in the theta rhythms of neuronal firing could be explained by changes of the theta rhythms in local field potentials. High-frequency axonal stimulation might prevent the original rhythmic excitation in afferent fibers and generate new excitation by stimulation pulses per se, thereby suppressing the theta rhythms of individual neuron firing and of local field potentials in the region downstream from stimulation. The results provide new evidence to support the hypothesis that high-frequency stimulation can alter the firing rhythms of neurons, which may underlie the therapeutic effects of deep brain stimulation.

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Section: Discussionmentioning

confidence: 99%

Section: Analysis Of Single Unit Spikesmentioning

confidence: 99%

Section: Analysis Of Single Unit Spikesmentioning

confidence: 99%

Section: Hfs Changed the Rhythms In Neuronal Firingmentioning

confidence: 99%

See 2 more Smart Citations

High-frequency stimulation of afferent axons alters firing rhythms of downstream neurons

Feng

Wang

et al. 2019

J. Integr. Neurosci.

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“…Despite extensive research, its mechanism of action remains incompletely understood, which limits the development of more rational and efficacious stimulation protocols. Various hypotheses on its mode of action have been proposed, including depolarization block, synaptic depression, synaptic and recurrent inhibition, axonal conduction block, overriding pathological activity by imposing new (stimulus‐locked) activity, desynchronization and suppression of pathological oscillations, neuroplasticity, neurogenesis, and neuroprotective effects 1–11 …”

Section: Introductionmentioning

confidence: 99%

Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats: Potential neurophysiological basis for intermittent as an alternative to continuous stimulation

et al. 2020

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Objective: Deep brain stimulation (DBS) is an increasingly applied treatment for various neuropsychiatric disorders including drug-resistant epilepsy, and it may be optimized by rationalizing the stimulation protocol based on increased knowledge of its mechanism of action. We evaluated the effects of minutes to hours of hippocampal DBS on hippocampal evoked potentials (EPs) and local field potentials (LFPs) in freely moving male rats to further investigate some of the previously proposed mechanisms of action. Methods: Hippocampal high-frequency (130 Hz) DBS was administered for 0, 1, or 6 min every 10 min for 160 min. Stimulation parameter settings were similar to those that had previously been shown to reduce seizures in epileptic rats. EPs and LFPs were recorded in the stimulation-free intervals. We investigated both the immediate temporary effects of 1 or 6 min of DBS and the effects of 160 min of intermittent DBS. Input specificity was investigated by using two different stimulation electrodes. Results: Relatively low DBS intensities corresponding to only 1.8% of the intensity evoking a maximum EP were required to prevent unintended seizure occurrence in healthy rats. Both 1 and 6 min of DBS caused input-specific short-lasting (<60 s) reductions (5%-7%) of the field excitatory postsynaptic potential (fEPSP) slope (P = .005). We observed longer-lasting, input-specific EP reductions during the 160 min intermittent DBS, with statistically significant reductions (3%-4%) of the fEPSP slope (P = .009-.018). The LFP spectrogram remained unaltered. Significance: Deep brain stimulation induced both acute temporary effects compatible with axonal block and/or synaptic depression, and longer-lasting potentially cumulative EP reductions, suggesting the involvement of homeostatic plasticity or long-term depression. This dual time course may parallel the different temporal patterns of improvement observed in clinical trials. The longer-lasting reductions provide a potential neurophysiological basis for the use of intermittent DBS-as typically used in epilepsy patients-as an alternative to continuous DBS. |SPRENGERS Et al.

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Stochastic dynamics of conduction failure of action potential along nerve fiber with Hopf bifurcation

Zhang

Guan

2019

Sci. China Technol. Sci.

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High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction

Cited by 32 publications

References 42 publications

High-frequency stimulation of afferent axons alters firing rhythms of downstream neurons

High-frequency stimulation of afferent axons alters firing rhythms of downstream neurons

Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats: Potential neurophysiological basis for intermittent as an alternative to continuous stimulation

Stochastic dynamics of conduction failure of action potential along nerve fiber with Hopf bifurcation

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