High-Frequency Repetitive Transcranial Magnetic Stimulation Improves Refractory Depression by Influencing Catecholamine and Brain-Derived Neurotrophic Factors

Yukimasa, Toru; Yoshimura, Reiji; Tamagawa, Akira; Uozumi, Takashi; Shinkai, Koji; Ueda, Nobuhisa; Tsuji, Shoji; Nakamura, Jun

doi:10.1055/s-2006-931542

Cited by 130 publications

(76 citation statements)

References 47 publications

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“…The effect of rTMS on BDNF levels in depressed subjects has received considerably greater attention because of the strong links between BDNF and the pathophysiology of depression (Krishnan and Nestler, 2008;Taliaz et al, 2010). In depressed patients who responded to TMS treatment, both high-frequency (Yukimasa et al, 2006;Zanardini et al, 2006) and low-frequency (Zanardini et al, 2006) rTMS were reported to increase BDNF serum levels; however, a different study reported no change induced by high-frequency rTMS (Lang et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Markers for Neuroplasticity: Differential Outcomes in Anesthetized and Awake Animals

Gersner

Kravetz

Feil³

et al. 2011

J. Neurosci.

256

181

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Long-term effects of repetitive transcranial magnetic stimulation (rTMS) have been associated with neuroplasticity, but most physiological studies have evaluated only the immediate effects of the stimulation on neurochemical markers. Furthermore, although it is known that baseline excitability state plays a major role in rTMS outcomes, the role of spontaneous neural activity in metaplasticity has not been investigated. The first aim of this study was to evaluate and compare the long-term effects of high-and low-frequency rTMS on the markers of neuroplasticity such as BDNF and GluR1 subunit of AMPA receptor. The second aim was to assess whether these effects depend on spontaneous neural activity, by comparing the neurochemical alterations induced by rTMS in anesthetized and awake rats. Ten daily sessions of high-or low-frequency rTMS were applied over the rat brain, and 3 d later, levels of BDNF, GluR1, and phosphorylated GluR1 were assessed in the hippocampus, prelimbic cortex, and striatum. We found that high-frequency stimulation induced a profound effect on neuroplasticity markers; increasing them in awake animals while decreasing them in anesthetized animals. In contrast, low-frequency stimulation did not induce significant long-term effects on these markers in either state. This study highlights the importance of spontaneous neural activity during rTMS and demonstrates that high-frequency rTMS can induce long-lasting effects on BDNF and GluR1 which may underlie the clinical benefits of this treatment in neuroplasticity-related disorders.

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Section: Discussionmentioning

confidence: 99%

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Markers for Neuroplasticity: Differential Outcomes in Anesthetized and Awake Animals

Gersner

Kravetz

Feil³

et al. 2011

J. Neurosci.

256

181

View full text Add to dashboard Cite

show abstract

“…Using standard figure-of-8 coils, two groups have found increased BDNF serum levels after high-frequency treatment [7,8] of depressed patients, but the same also observed increased BDNF levels following low-frequency treatment [8], and a third group found no effect on BDNF serum levels in response to high-frequency treatment of depression [14]. Many groups have focused on a connection between depression and BDNF concentration.…”

Section: Discussionmentioning

confidence: 99%

“…A potential effect of rTMS on BDNF concentration in these diseases has been explored in previous studies [7,8]. The BDNF concentration in serum [9,10] or plasma [11] is decreased in depressed patients and may be associated with characteristics of neuroticism in healthy people [10], and antidepressant therapy has been suggested as potentially affecting BDNF concentration, mostly in the form of increasing peripheral blood concentrations [6,12,13].…”

Section: Introductionmentioning

confidence: 99%

Effects of Deep Repetitive Transcranial Magnetic Stimulation on Brain-Derived Neurotrophic Factor Serum Concentration in Healthy Volunteers

Gaede

Hellweg²,

Zimmermann³

et al. 2014

Neuropsychobiology

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Objective: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, safe and efficacious technique for treating various neuropsychiatric disorders, but its underlying mechanisms are poorly understood. A newly developed H-coil allows the stimulation of deeper brain regions. This study is the first to investigate the effects of deep high-frequency rTMS on brain-derived neurotrophic factor (BDNF) serum concentrations in healthy volunteers. We aimed to evaluate the short-term effect of deep rTMS on BDNF serum concentrations. Methods: This was a double-blind, randomized deep high-frequency rTMS study using an H-coil on a cohort of 13 healthy volunteers (NCT01106365). The following stimulation protocols were applied: 18-Hz stimulation of the left dorsolateral prefrontal cortex (PFC), 5-Hz stimulation of the primary motor cortex (MC) and sham stimulation in random order. Blood samples were obtained before, 30 min after and 60 min after each treatment. Results: The BDNF serum concentration decreased significantly after MC and PFC stimulation, but not after sham stimulation. Furthermore, BDNF serum level changes were associated with changes in individual alertness. Conclusion: Although BDNF serum concentrations do not necessarily correlate with BDNF levels in the cerebrospinal fluid or the brain, these results indicate an acute biological effect of deep rTMS on BDNF release, and demonstrate that this change correlates with alertness.

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“…The plasma was quickly separated in a centrifuge and stored at À808C until assayed. The plasma HVA and MHPG levels were analyzed by HPLC-ECD according to the method described previously The plasma BDNF levels were measured using a BDNF Emax Immunoassay Kit (Promega, Madison, WI, USA) according to the method described previously (Yukimasa et al, 2006). The protocol of this study was approved by the Ethics Committee of the University of Occupational and Environmental Health.…”

Section: Methodsmentioning

confidence: 99%

Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders

Yoshimura

Nakano

Hori

et al. 2006

Human Psychopharmacology

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A combination treatment with a mood stabilizer and an antipsychotic drug is often used in as many as 90% of subjects with acute mania. Recently, augmentation therapy with atypical antipsychotics has been investigated in both the acute and long-term treatment of bipolar disorder with or without psychosis. In the present study, the authors investigated the efficacy of risperidone treatment for both acute manic and depressive episodes in bipolar disorder. Eighteen patients (M/F: 8/10, age: 34 +/- 15 yr) who met the DSM-IV criteria for bipolar I disorder (12 cases of manic episodes, 6 cases of depressive episodes) with risperidone treatment were evaluated regarding their clinical improvement using the Young Mania rating Scale (YMRS) and the Hamilton rating Scale for Depression (Ham-D). Plasma concentrations of HVA and MHPG were analyzed by HPLC-ECD and plasma brain-derived neurotrophic factor (BDNF) levels were detected by sandwich ELISA. The mean scores of the YMRS were 22, 18, 12, 8, and 5 at time points before and 1, 2, 3, and 4 weeks after the risperidone administration, respectively. The mean scores of the Ham-D were 24, 25, 21, 21, and 19 at time points before and 1, 2, 3, and 4 weeks after the risperidone administration, respectively. The plasma levels of HVA and 3-methoxy-4-hydroxyphenylglycol (MHPG) were observed to have decreased 4 weeks after risperidone administration in manic patients. The levels did not change in depressive patients. The plasma levels of BDNF were decreased in depressive patients compared with manic patients or healthy controls. However, the administration of risperidone did not alter plasma BDNF levels.

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High-Frequency Repetitive Transcranial Magnetic Stimulation Improves Refractory Depression by Influencing Catecholamine and Brain-Derived Neurotrophic Factors

Abstract: These results suggest that rTMS treatment brings about some improvement in refractory depression, especially for symptoms such as agitation, by influencing MHPG and BDNF, which is in accordance with previous reports showing that BDNF was increased by various antidepressants treatments.

Cited by 130 publications

References 47 publications

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Markers for Neuroplasticity: Differential Outcomes in Anesthetized and Awake Animals

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Markers for Neuroplasticity: Differential Outcomes in Anesthetized and Awake Animals

Effects of Deep Repetitive Transcranial Magnetic Stimulation on Brain-Derived Neurotrophic Factor Serum Concentration in Healthy Volunteers

Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders

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