High frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex for methamphetamine use disorders: A randomised clinical trial

Su, Hang; Zhong, Na; Gan, Hong; Wang, Jijun; Han, Hao; Chen, Tianzhen; Li, Xiaotong; Xue-yu, Ruan; Zhu, Youwei; Jiang, Haifeng; Zhao, Min

doi:10.1016/j.drugalcdep.2017.01.037

Cited by 90 publications

(79 citation statements)

References 55 publications

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“…Methamphetaminedependent subjects do not show considerable cognitive gains in the first month of abstinence [37], and not all the impairment is recoverable along with prolonged abstinence (13-month on average), such as verbal, learning and memory, executive functions [38] which are related to the function of superior frontal gyrus. In recent years, accumulating evidences have shown that repetitive transcranial magnetic stimulation (rTMS) over dorsallateral prefrontal cortex is beneficial for methamphetamine dependents by alleviating craving, withdrawal symptoms, depression and anxiety [39][40][41][42], and by improving sleep quality [39], verbal learning and memory and social cognition [42]. These results may help to support studies of whether deep brain or transcranial stimulation over the altered regions is beneficial for methamphetamine-induced neurocognitive disfunctions.…”

Section: Discussionmentioning

confidence: 99%

Gray-matter structure in long-term abstinent methamphetamine users

Nie

Zhao

Wen³

et al. 2020

BMC Psychiatry

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Background: Previous studies of brain structure in methamphetamine users have yielded inconsistent findings, possibly reflecting small sample size and inconsistencies in duration of methamphetamine abstinence as well as sampling and analyses methods. Here we report on a relatively large sample of abstinent methamphetamine users at various stages of long-term abstinence. Methods: Chronic methamphetamine users (n = 99), abstinent from the drug ranging from 12 to 621 days, and healthy controls (n = 86) received T1-weighted structural magnetic resonance imaging brain scans. Subcortical and cortical gray-matter volumes and cortical thickness were measured and the effects of group, duration of abstinence, duration of methamphetamine use and onset age of methamphetamine use were investigated using the Freesurfer software package. Results: Methamphetamine users did not differ from controls in gray-matter volumes, except for a cluster in the right lateral occipital cortex where gray-matter volume was smaller, and for regions mainly in the bilateral superior frontal gyrui where thickness was greater. Duration of abstinence correlated positively with gray-matter volumes in whole brain, bilateral accumbens nuclei and insulae clusters, and right hippocampus; and with thickness in a right insula cluster. Duration of methamphetamine use correlated negatively with gray-matter volume and cortical thickness of a cluster in the right lingual and pericalcarine cortex. Conclusions: Chronic methamphetamine use induces hard-to-recover cortical thickening in bilateral superior frontal gyri and recoverable volumetric reduction in right hippocampus, bilateral accumbens nuclei and bilateral cortical regions around insulae. These alternations might contribute to methamphetamine-induced neurocognitive disfunctions and reflect a regional specific response of the brain to methamphetamine.

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Section: Discussionmentioning

confidence: 99%

Gray-matter structure in long-term abstinent methamphetamine users

Nie

Zhao

Wen³

et al. 2020

BMC Psychiatry

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“…Thus far, there have been only three studies investigating rTMS for methamphetamine (MA) dependence . Su et al applied five sessions of 10 Hz rTMS to the left DLPFC. Results indicated a significant reduction in cravings for MA compared to sham stimulation.…”

Section: Resultsmentioning

confidence: 99%

“…With respect to effects of brain stimulation observed between SUDs, commonalities between rTMS and tDCS emerged. Studies utilizing rTMS observed promising findings in trials conducted in nicotine or stimulant (cocaine, methamphetamine) dependent samples, with 10/11 and 5/7 positive studies, respectively in domains of craving and/or consumption. Moreover, in alcohol‐dependent participants, 6/9 studies suggested reductions in alcohol craving and/or consumption after active rTMS treatment.…”

Section: Discussionmentioning

confidence: 99%

A review of brain stimulation methods to treat substance use disorders

2018

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Background Substance use disorders (SUDs) are a leading cause of disability worldwide. While several pharmacological and behavioral treatments for SUDs are available, these may not be effective for all patients. Recent studies using non-invasive neuromodulation techniques including Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS) have shown promise for SUD treatment. Objective Multiple studies were evaluated investigating the therapeutic potential of non-invasive brain stimulation techniques in treatment of SUDs. Method Through literature searches (eg, PubMed, Google Scholar), 60 studies (2000–2017) were identified examining the effect of rTMS, tDCS, or DBS on cravings and consumption of SUDs, including tobacco, alcohol, cannabis, opioids, and stimulants. Results rTMS and tDCS demonstrated decreases in drug craving and consumption, while early studies with DBS suggest similar results. Results are most encouraging when stimulation is targeted to the Dorsolateral Prefrontal Cortex (DLPFC). Conclusions Short-term treatment with rTMS and tDCS may have beneficial effects on drug craving and consumption. Future studies should focus on extending therapeutic benefits by increasing stimulation frequency and duration of treatment. Scientific Significance The utility of these methods in SUD treatment and prevention are unclear, and warrants further study using randomized, controlled designs.

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“…Indeed, the long-term neurophysiological changes induced by rTMS on frontal brain regions have the potential to affect behaviors related to drug craving, intake, and relapse and have been proposed as a significant biomarker for predicting treatment outcome. Human laboratory studies with rTMS suggest that the site we stimulated, left DLPFC, might also be an appropriate target for people with addictions to heroin (28), methamphetamine (29,30), nicotine (31), or cannabis (32).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcome of Repetitive Transcranial Magnetic Stimulation in a Large Cohort of Patients With Cocaine-Use Disorder: An Observational Study

et al. 2020

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Background: Cocaine is a psychostimulant drug used as performance enhancer throughout history. The prolonged use of cocaine is associated with addiction and a broad range of cognitive deficits. Currently, there are no medications proven to be effective for cocaine-use disorder (CocUD). Previous preliminary clinical work suggests some benefit from repetitive transcranial magnetic stimulation (rTMS) stimulating the prefrontal cortex (PFC), involved in inhibitory cognitive control, decision-making and attention. All published studies to date have been limited by small sample sizes and short follow-up times.Methods: This is a retrospective observational study of 284 outpatients (of whom 268 were men) meeting DSM-5 criteria for CocUD. At treatment entry, most were using cocaine every day or several times per week. All patients underwent 3 months of rTMS and were followed for up to 2 years, 8 months. Self-report, reports by family or significant others and regular urine screens were used to assess drug use.Results: Median time to the first lapse (resumption of cocaine use) since the beginning of treatment was 91 days. For most patients, TMS was re-administered weekly, then monthly, throughout follow-up. The decrease in frequency of rTMS sessions was not accompanied by an increase in lapses to cocaine use. Mean frequency of cocaine use was <1·0 day/month (median 0), while serious rTMS-related adverse events were infrequent, consistent with published reports from smaller studies.Conclusions: This is the first follow-up study to show that rTMS treatment is accompanied by long-lasting reductions in cocaine use in a large cohort.

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High frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex for methamphetamine use disorders: A randomised clinical trial

Cited by 90 publications

References 55 publications

Gray-matter structure in long-term abstinent methamphetamine users

Gray-matter structure in long-term abstinent methamphetamine users

A review of brain stimulation methods to treat substance use disorders

Long-Term Outcome of Repetitive Transcranial Magnetic Stimulation in a Large Cohort of Patients With Cocaine-Use Disorder: An Observational Study

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