High-Frequency Quantitative Ultrasound Spectroscopy of Excised Canine Livers and Mouse Tumors Using the Structure Factor Model

Muleki-Seya, Pauline; Guillermin, Régine; Guglielmi, Julien; Chen, Jiangang; Pourcher, Thierry; Konofagou, Elisa E.; Franceschini, Émilie

doi:10.1109/tuffc.2016.2563169

Cited by 36 publications

(34 citation statements)

References 34 publications

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“…Figure 2 summarizes the ESD and EAC QUS parameters estimated from the SGM and SFM models. The ESD and EAC obtained from the sparse SGM and the concentrated SFM gave similar values for untreated liver at 37°C, as observed previously in previous experiments on ex vivo canine livers [5]. Whereas the ESD and EAC estimated by the sparse SGM and the concentrated SFM differ from each other for HIU treated samples.…”

Section: Resultssupporting

confidence: 86%

“…For each ROI, estimates of QUS parameters were obtained by fitting the measured BSCmeas with the SGM [3][4] or the SFM [5][6] within the 12-38 MHz bandwidth. The SGM yields estimates of ESD and EAC.…”

Section: B Quantitative Ultrasoundmentioning

confidence: 99%

“…The SFM yields three parameters the scatterer radius a, the scatterer volume fraction  and the relative impedance contrast  z , from which the EAC can be deduced: EAC=z 2 /((4/3)a 3 ). If both SGM and SFM gave similar scatterer sizes, the tissue may be considered as a sparse medium, and the SFM can only yield the ESD and EAC [5][6]. Otherwise, the tissue may be considered as a concentrated medium, and the SFM can yield the three QUS parameters (a, , z).…”

Section: B Quantitative Ultrasoundmentioning

confidence: 99%

“…The SGM yields two QUS estimates describing tissue microstructure: the average effective scatterer size (ESD) and the acoustic concentration (EAC) (i.e., the product of the scatterer number density and the square of the relative impedance difference between the scatterers and the surrounding medium). Another class of theoretical scattering model is the concentrated Structure Factor Model (SFM) that describes tissue as an ensemble of discrete scatterers and considers interference effects caused by coherent scattering using a structure function [5][6]. Changes in ESD and EAC QUS parameters have been correlated with the temperature changes during HIU exposure [7][8].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of High Intensity Ultrasound Exposures by Quantitative Ultrasound

Barrère

Franceschini

Melodelima

2019

2019 IEEE International Ultrasonics Symposium (IUS)

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High Intensity Ultrasound (HIU) is of proven value in the treatment of many medical disorders by using US energy without incisions or radiation. The development of an effective method for guiding HIU therapies remains necessary. Changes in spectral-based Quantitative UltraSound (QUS) parameters have been correlated with the temperature changes during HIU exposure (Ghoshal et al. IEEE UFFC 2016). The aim of this study is to quantify the changes in QUS parameters due to temperature elevation after HIU exposure of ex vivo bovine livers. The QUS experiments are conducted in high frequencies (12-38 MHz) to provide insight into the specific changes in liver tissues that cause the changes of backscatter properties for fixed temperature ranging from 37°C up to 80°C after HIU exposure. Samples of porcine livers are exposed to HIU using a plane 3 MHz transducer with aperture diameter of 4 cm. Samples were heated up to 37, 50, 60, 65, 70, 75, 80°C. After reaching the desired temperature, the sample is cut in half at the center of the lesion. US backscatter signals were recorded from the cut samples by using the Visualsonics Vevo 770 imaging system with the RMV710 probe of center frequency 25 MHz. The backscatter coefficients (BSCs) were estimated using the reference phantom technique and the attenuation coefficients were determined using a standard substitution method. Structural scatterer properties were estimated by fitting the measured BSCs with the spherical Gaussian model (SGM) or with the Structure Factor Model (SFM) to estimate the effective scatterer diameter (ESD) and acoustic concentration (EAC). The QUS parameters estimated by the sparse SGM and the concentrated SFM differ strongly from each other for HIU treated samples and suggests that the treated livers can be considered as concentrated media. Results showed that both integrated BSC and ESD estimated by the SFM increased as a function of temperature.

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Section: Resultssupporting

confidence: 86%

Section: B Quantitative Ultrasoundmentioning

confidence: 99%

Section: B Quantitative Ultrasoundmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of High Intensity Ultrasound Exposures by Quantitative Ultrasound

Barrère

Franceschini

Melodelima

2019

2019 IEEE International Ultrasonics Symposium (IUS)

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“…It has addressed that the size of ROI is encouraged to over five times from the size of resolution cell in the envelope statistics, 3,31) and 10 times of the wavelength of the center frequency is usually required for high accuracy analysis of BSC. 11,15,38) However, envelope statistics and BSC analysis were also performed with ROI size ten times wavelength, and its result was the same as eight times. Therefore, the axial ROI size which was smaller one was employed in this study.…”

Section: Methodsmentioning

confidence: 99%

Comprehensive backscattering characteristics analysis for quantitative ultrasound with an annular array: a basic study on homogeneous scattering phantom

Mizoguchi

Tamura

Mamou

et al. 2019

Jpn. J. Appl. Phys.

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High-frequency ultrasound (HFU, >20 MHz) and quantitative ultrasound (QUS) methods permit a means to understand the relationship between anatomical and acoustic characteristics. In our previous research, we showed that analyzing the acoustic scattering with HFU was an effective method for noninvasive diagnosis. However, the depth of field (DOF) of HFU transducers was limited, which constrains the range of QUS analysis. In this study, we seek to improve the accuracy of HFU, QUS-based parameters on the envelope statistics and frequency-based analysis by using an annular array that allows for an extended DOF. A 20-MHz annular-array transducer with five elements was employed to obtain signals which were beamformed in post-processing. Two kinds of low concentration scattering phantoms were scanned with 30-μm step size. Two QUS analysis techniques were employed: the Nakagami distribution and the reflector method. The results demonstrated that the annular array provides a stable analysis over an extended axial range.

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Quantitative ultrasound techniques for assessing thermal ablation: Measurement of the backscatter coefficient from ex vivo human liver

Rohfritsch,

Franceschini,

Dupré

et al. 2023

Medical Physics

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BackgroundUnderstanding the changes occurring in biological tissue during thermal ablation is at the heart of many current challenges in both therapy and medical imaging research.PurposeThe objective of this work is to quantitatively interpret the scattering response of human liver samples, before and after thermal ablation. We report acoustic measurements performed involving n = 21 human liver samples. Thermal ablation is achieved at temperatures between 45 and 80°C and quantification of the irreversible changes in acoustic attenuation and Backscattering Coefficient (BSC) is reported, with a particular attention to the latter.MethodsBoth attenuation coefficient and BSCs were measured in the frequency range from 10 to 52 MHz. Scans were performed before heating and after cooling down. Attenuation coefficients were calculated using spectral difference method and BSC estimated using the reference phantom method.ResultsStrong increases of attenuation coefficients and BSCs with heating temperature were observed. Quantitative ultrasonic parameters obtained with the polydisperse structure factor model (poly‐SFM)are compared to histological observations and seen to be close to hepatocyte mean diameter (HMD).ConclusionsThe results presented in this study provide a description of the impact of thermal ablation in human liver tissue on acoustic attenuation and the BSC. For the first time, quantitative agreement between the Effective Scatterer Diameter (ESD) estimated from BSC and HMD was shown, highlighting the important role of cellular network in the scattering response of the medium. This core result is an important step toward the determination of the nature of scattering sources in biological tissues.

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High-Frequency Quantitative Ultrasound Spectroscopy of Excised Canine Livers and Mouse Tumors Using the Structure Factor Model

Cited by 36 publications

References 34 publications

Characterization of High Intensity Ultrasound Exposures by Quantitative Ultrasound

Characterization of High Intensity Ultrasound Exposures by Quantitative Ultrasound

Comprehensive backscattering characteristics analysis for quantitative ultrasound with an annular array: a basic study on homogeneous scattering phantom

Quantitative ultrasound techniques for assessing thermal ablation: Measurement of the backscatter coefficient from ex vivo human liver

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