High frequency oscillatory ventilation in a cohort of children with respiratory failure

Stewart, Claire; Yehya, Nadir; Lin, Fang; Chima, Ranjit S.

doi:10.1002/ppul.24006

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…In our neonate population suffering from a congenital diaphragmatic hernia, the survival rate at NICU discharge was consistent with previous published studies, 17 suggesting that there was no additional mortality related to the transportation. In our pediatric population, the survival rate was similar to that reported in a recent study which reported similar OI as in our study (56% vs. 58%) 18 . These results demonstrate the feasibility and the safety of HFOV transportations with a trained PICU‐TT, despite some inherent challenges.…”

Section: Discussionsupporting

confidence: 90%

A twelve‐year neonatal and pediatric high‐frequency oscillatory ventilation transport experience

Piloquet

Genuini

Kessous

et al. 2020

Pediatric Pulmonology

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Objective To describe the evolution over a 12‐year period of a pediatric intensive care unit transport team's (PICU‐TT) experience of pediatric and neonatal interhospital transportation on high‐frequency oscillation ventilation (HFOV). Methods This was a monocentric retrospective observational study from January 2006 to December 2017. All patients aged under 18 years old who were transported on HFOV by the Robert Debré Hospital PICU‐TT were included. Results Over a 12‐year period, 125 patients were transported on HFOV, including 107 newborns and 18 children. Median (range) age and weight were 9 days (1 h–9 years) and 3.3 (0.6–39) kg, respectively. Initial median oxygenation index, SpO2/FiO2 ratio and mean airway pressure were 32, 91, and 18 cmH2O, respectively, without significant difference between values before and after transport. Adverse events occurred during 28 transportations (22%) including three recovered cardiac arrests and one death. Overall survival rate at discharge was 74%, 78% in neonates and 56% in pediatrics, respectively. HFOV transportation rate increased over the last four years of the study for neonates and remained stable for older children. Extra‐corporeal membrane oxygenation (ECMO) initiation rate on arrival decreased and survival rate increased significantly during the last four years of the study (p < .05). Conclusion This study showed the feasibility of HFOV transportation by a PICU‐TT, despite some challenges. A trend towards using ECMO more than HFOV for the most severe respiratory and/or circulatory failures was seen over the 12‐year period. The HFOV transportation rate has increased for less severe neonatal patients.

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Section: Discussionsupporting

confidence: 90%

A twelve‐year neonatal and pediatric high‐frequency oscillatory ventilation transport experience

Piloquet

Genuini

Kessous

et al. 2020

Pediatric Pulmonology

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“…Since PALICC, many studies have corroborated the impact of previously identified comorbidities—most notably immunodeficiency (1–21)—and PARDS triggers (22–81) on severity of PARDS or PARDS outcomes. It remains clear that both comorbidities and the many conditions that cause PARDS contribute to the heterogeneity seen in this syndrome.…”

Section: Resultsmentioning

confidence: 93%

“…Furthermore, there has yet to be an effective pharmacologic treatment for PARDS, and care is supportive. In addition, PARDS is a heterogeneous condition due in part to differences among children in the underlying pathobiology, age (which impacts changes in the lungs, chest wall, and immune system associated with development), comorbidities (1–21), and inciting trigger (22–85).…”

mentioning

confidence: 99%

Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference

Grunwell

Dahmer

Sapru

et al. 2023

Pediatric Critical Care Medicine

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To review the literature for studies published in children on the pathobiology, severity, and risk stratification of pediatric acute respiratory distress syndrome (PARDS) with the intent of guiding current medical practice and identifying important areas for future research related to severity and risk stratification.DATA SOURCES: Electronic searches of PubMed and Embase were conducted from 2013 to March 2022 by using a combination of medical subject heading terms and text words to capture the pathobiology, severity, and comorbidities of PARDS. STUDY SELECTION:We included studies of critically ill patients with PARDS that related to the severity and risk stratification of PARDS using characteristics other than the oxygenation defect. Studies using animal models, adult only, and studies with 10 or fewer children were excluded from our review.DATA EXTRACTION: Title/abstract review, full-text review, and data extraction using a standardized data collection form. DATA SYNTHESIS:The Grading of Recommendations Assessment, Development, and Evaluation approach was used to identify and summarize relevant evidence and develop recommendations for clinical practice. There were 192 studies identified for full-text extraction to address the relevant Patient/ Intervention/Comparator/Outcome questions. One clinical recommendation was generated related to the use of dead space fraction for risk stratification. In addition, six research statements were generated about the impact of age on acute respiratory distress syndrome pathobiology and outcomes, addressing PARDS heterogeneity using biomarkers to identify subphenotypes and endotypes, and use of standardized ventilator, physiologic, and nonpulmonary organ failure measurements for future research. CONCLUSIONS:Based on an extensive literature review, we propose clinical management and research recommendations related to characterization and risk stratification of PARDS severity.

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“…Moreover, our study showed a higher mortality in patient with hematological malignancies. The higher mortality when using HFOV for refractory hypoxemia associated with malignancies and in post-stem cell transplant cases has been described by more than one recent publication [13,14]. These cases deserve the highest degree of vigilance and need additional well-designed trials to account for all possible confounding variables.…”

Section: Discussionmentioning

confidence: 99%

High Frequency Oscillatory Ventilation in Pediatric Practice: A Single Center Experience in Saudi Arabia

Gabr¹,

Aboo²,

Zahraa³

2021

Int J Pediatr Neonat Care

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No standardized international practice guidelines are available for the proper indications for switching from conventional mode to HFOV, which cases will improve better on HFOV, and proper adjustment of the HFOV settings. Therefore, the objectives of this study were to identify which patient profiles could be best treated with HFOV in medical centers, especially with the lack of readily available extracorporeal membranous oxygenation (ECMO) rescue therapy, which ones will not improve or even worsen the condition, and the best possible way of selecting and adjusting HFOV settings in the first 48 h. Materials and MethodsA retrospective observational study was conducted in the pediatric intensive care unit (PICU) at King Fahad Medical City (KFMC), a tertiary care hospital located in Riyadh, the capital of Saudi Arabia, between September 2010 and December 2017. All patients under

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High frequency oscillatory ventilation in a cohort of children with respiratory failure

Cited by 3 publications

References 18 publications

A twelve‐year neonatal and pediatric high‐frequency oscillatory ventilation transport experience

A twelve‐year neonatal and pediatric high‐frequency oscillatory ventilation transport experience

Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference

High Frequency Oscillatory Ventilation in Pediatric Practice: A Single Center Experience in Saudi Arabia

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