High-frequency oscillatory ventilation in adult acute respiratory distress syndrome

Comparison of prone positioning and high-frequency oscillatory ventilation in patients with acute respiratory distress syndrome*

“…We chose to evaluate the effects of each strategy after a 12-hr period of conventional lung-protective mechanical ventilation for several reasons. First, an early improvement in oxygenation with a peak after 12 hrs of HFOV but a slight decrease after 24 hrs of HFOV has been reported (23,41). Therefore, the 12-hr study period of both strategy used in the present study would have favored HFOV.…”

Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome*

“…The Sensormedics 3100B (Sensormedics, Loma Linda, CA) is the only highfrequency ventilator approved by the Food and Drug Administration for use in adults with ALI/ARDS. It has been assumed that this ventilator delivers very small tidal volumes (VTs) (2)(3)(4)(5)(6)(7)(8). However, the 3100B is a pressure-cycling machine that neither monitors nor directly controls VT, and the magnitudes of VT it delivers to adults with ALI/ARDS have not been assessed systematically.…”

Mechanical ventilation during acute lung injury: Current recommendations and new concepts

“…Most of the evidence for HFO has been from small observational studies, often in the setting of refractory hypoxemia. These studies have shown that HFO is technically feasible and generally tolerated, resulting in improvements in oxygenation [107][108][109][110]. Complications reported with HFO are relatively infrequent and include barotrauma [107,110,111], hemodynamic compromise [108,110], mucus inspissations resulting in endotracheal tube occlusion or refractory hypercapnia, and increased use of sedation or neuromuscular blocking agents (NMBA) [107,108,111,112].…”