High frequency oscillations in the subthalamic nucleus: A neurophysiological marker of the motor state in Parkinson's disease

Özkurt, Tolga Esat; Butz, Markus; Homburger, M.; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons

doi:10.1016/j.expneurol.2011.02.015

Cited by 172 publications

(215 citation statements)

References 36 publications

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“…In eight PD patients, we found a significant interaction between the phase of the β-rhythm and the amplitude of a relatively narrowband high-frequency oscillation (HFO) at >200 Hz (Fig. S4), which has previously been described (18,19). This pattern of STN-STN phase-amplitude coupling is distinct from β-phasebroadband-γ coupling in that the amplitude frequency over which coupling occurs is both high and narrowband.…”

Section: Resultsmentioning

confidence: 52%

Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease

Hemptinne¹,

Ryapolova-Webb²,

Air

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

481

471

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An important mechanism for large-scale interactions between cortical areas involves coupling between the phase and the amplitude of different brain rhythms. Could basal ganglia disease disrupt this mechanism? We answered this question by analysis of local field potentials recorded from the primary motor cortex (M1) arm area in patients undergoing neurosurgery. In Parkinson disease, coupling between β-phase (13-30 Hz) and γ-amplitude (50-200 Hz) in M1 is exaggerated compared with patients with craniocervical dystonia and humans without a movement disorder. Excessive coupling may be reduced by therapeutic subthalamic nucleus stimulation. Peaks in M1 γ-amplitude are coupled to, and precede, the subthalamic nucleus β-trough. The results prompt a model of the basal ganglia-cortical circuit in Parkinson disease incorporating phase-amplitude interactions and abnormal corticosubthalamic feedback and suggest that M1 local field potentials could be used as a control signal for automated programming of basal ganglia stimulators.electrocorticography | cross-frequency coupling

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Section: Resultsmentioning

confidence: 52%

Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease

Hemptinne¹,

Ryapolova-Webb²,

Air

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

481

471

View full text Add to dashboard Cite

show abstract

“…In addition, the so-called high-frequency oscillations (HFO, >200 Hz) were observed in the basal ganglia of patients with Parkinson's disease [51][52][53]. HFO are involved in the generation of voluntary movements.…”

Section: Discussionmentioning

confidence: 99%

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Pyragas¹,

Tass²

2017

Lith. J. Phys.

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We analyze the influence of high-frequency current stimulation on spontaneous neuronal activity and show that it may cause a death of spontaneous low-frequency oscillations. We demonstrate the universality of this effect for typical neuron models such as FitzHugh-Nagumo, Morris-Lecar, and Hodgkin-Huxley neurons as well as for the normal form of the supercritical Hopf bifurcation. Using a multiple scale method we separate the solutions of the neuron equations into slow and fast components and derive averaged equations for the slow components. The mechanism of suppression of neuronal activity is explained by an analysis of the bifurcations in the averaged equations governing the dynamics of the slow motion. Our results may contribute to the understanding of therapeutic effects of high-frequency deep brain stimulation, the golden standard for the treatment of medically refractory patients suffering from Parkinson's disease. Furthermore, our study enables hypotheses concerning possible improvements of high-frequency deep brain stimulation.

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“…For instance, high frequency power ratios, phase amplitude coupling and beta variability have all been shown to relate to Parkinsonian state 9,10,12,17 . The method described in this paper should enable the systematic investigation of such parameters and their effect on the clinical efficacy of stimulation in addition to their side effect profile.…”

Section: Discussionmentioning

confidence: 99%

“…They are stable and robust in the long term and can be recorded from the same electrodes used for clinical DBS making them attractive targets for biomarkers 8 . In addition to beta oscillations, a range of other, more complex, potential biomarkers have been identified that have been shown to relate to severity of symptoms 2,[9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Little

Pogosyan

Neal³

et al. 2014

JoVE

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Adaptive deep brain stimulation (aDBS) has the potential to improve the treatment of Parkinson's disease by optimizing stimulation in real time according to fluctuating disease and medication state. In the present realization of adaptive DBS we record and stimulate from the DBS electrodes implanted in the subthalamic nucleus of patients with Parkinson's disease in the early post-operative period. Local field potentials are analogue filtered between 3 and 47 Hz before being passed to a data acquisition unit where they are digitally filtered again around the patient specific beta peak, rectified and smoothed to give an online reading of the beta amplitude. A threshold for beta amplitude is set heuristically, which, if crossed, passes a trigger signal to the stimulator. The stimulator then ramps up stimulation to a pre-determined clinically effective voltage over 250 msec and continues to stimulate until the beta amplitude again falls down below threshold. Stimulation continues in this manner with brief episodes of ramped DBS during periods of heightened beta power.Clinical efficacy is assessed after a minimum period of stabilization (5 min) through the unblinded and blinded video assessment of motor function using a selection of scores from the Unified Parkinson's Rating Scale (UPDRS). Recent work has demonstrated a reduction in power consumption with aDBS as well as an improvement in clinical scores compared to conventional DBS. Chronic aDBS could now be trialed in Parkinsonism.

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High frequency oscillations in the subthalamic nucleus: A neurophysiological marker of the motor state in Parkinson's disease

Cited by 172 publications

References 36 publications

Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease

Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

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