High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus

Park, Eun-Ho; Chang, Hwa-Hyoung; Lee, Kyoung‐Charn; Kweon, Hee‐Seok; Heo, Ok-Soon; Ha, Kwang‐Won

doi:10.1111/j.1349-7006.1993.tb02020.x

Cited by 27 publications

(18 citation statements)

References 21 publications

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“…With scale removal, the scale-associated cells are also removed, and there is proliferation of the scale pocket lining cells into layers with the production of scale matrix. There is also a close association between the scale-forming cells and the epidermis, which guarantees that only 1 scale will reform within the scale pocket (2,39,44 (40) and thyroid hyperplasia and ectopic follicles in liver from DEN (21) were reported in rivulus. In the present study, all of the MNNG-induced thyroid neoplasms were seen in males.…”

Section: Neoplasms Of Epithelial Originmentioning

confidence: 98%

N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*¹

Bunton

Wolfe

1996

Toxicol Pathol

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To test the sensitivity of the small fish species Oryzias latipes to the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), medaka were exposed at 15 days of age to 30 mg/L for 1 hr and followed for up to 16 mo. One hundred neoplasms were diagnosed in 84 of 213 exposed fish, with approximately equal percentages in males and females. Many neoplasms (62%) were of mesenchymal origin and were categorized as blood vascular neoplasms (hemangioma and hemangiosarcoma), invasive sarcomas, and scale-associated neoplasms. Invasive sarcomas included rhabdomyosarcoma, fascial sarcoma, hemangiopericytoma, and undifferentiated sarcoma. A scale-associated neoplasm, termed lepidocytoma, was an unusual neoplasm of scale anlage. Thyroid follicular neoplasms, with a 100% incidence in males, and pancreatic acinar carcinoma were the most common epithelial tumors. Neoplasms of the gills, swim bladder, and olfactory epithelium were also seen as well as teratoma with mixed epithelial and mesenchymal components. The study showed a broad range of neoplasms induced by MNNG in medaka, with a tissue distribution that might support direct action on exposed tissues.

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Section: Neoplasms Of Epithelial Originmentioning

confidence: 98%

N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*¹

Bunton

Wolfe

1996

Toxicol Pathol

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“…Thyroid neoplasms were seen in rivulus exposed at 1 wk of age, but neoplasms in other tissues were not induced (145). Osteogenic neoplasms were reported in coho salmon (Oncorhynchus kisutch) exposed as embryos (21 ) and in channel catfish (41).…”

Section: Chemicals and Protocolsmentioning

confidence: 99%

Review Article: Experimental Chemical Carcinogenesis in Fish

Bunton

1996

Toxicol Pathol

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Dr. Bunton's primary research interest is on mechanisms of toxicity and carcinogenesis in fish related to environmental contamination and on the development of alternative models.Experimental carcinogenesis using fish species as alternative models is a dynamic field of research. The 1940's expansion of synthetic chemical producing industries coincided with a number of pollution-associated fish neoplasia epizootics, with polycyclic aromatic hydrocarbons as significant components of contaminated sediment in several cases. Epizootics of primarily liver and skin neoplasia in benthic species near coastal urban or industrial areas indicated the sensitivity of fish species to known mammalian carcinogens. Stressing a mechanistic approach, investigators have used data compiled from epizootics as the backbone of current research efforts to define carcinogenesis in fish species. With liver as the focus, patterns of neoplastic development similar to those seen in rodent bioassays have been induced in various fish species by genotoxic carcinogens. Similarities between fish and rodent models include chemical and species-specific responses to exposure and the development of predictable preneoplastic and neoplastic lesions. The expression of molecular molecules related to carcinogenesis is currently under investigation, which includes alterations in certain proteins, enzyme activity, and oncogene/tumor suppressor gene function. The potential for the application of research findings to both human and environmental health issues makes fish species attractive and valuable alternative models in carcinogenesis and toxicity research.Keywords. Medaka; methylazoxymethanol (MAM); molecular markers; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG); Neoplasia; polycyclic aromatic hydrocarbons (PAH); rainbow trout INTRODUCTION Armed with data from fish neoplasia epizootics related to environmental synthetic chemical contamination, research has moved from the morphologic assessment of neoplasms to the identification of molecular mechanisms of neoplastic development and progression. The value of these studies can be argued along 2 lines that are often, but should not be, separated. One is for application to human health issues for which there is a chronic demand, and the other is the inherent value of monitoring the health of the environment, which includes all of the creatures therein. Unfortunately, it is the latter argument that most often has to be vigorously defended, although minimal reflection will reveal that we, too, are members of this population.The present review discusses experimental fish carcinogenesis by first presenting data from neoplasia epizootics that helped to form the framework of our current 604 research efforts. The effects of known direct and indirect carcinogens on various fish species from laboratory studies are then described to illustrate species similarities and differences in tissue response. The latter portion of the paper concentrates on chemical hepatocarcinogenesis and reviews the histologic and molecular marke...

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“…One case of follicular-derived thyroid cancer was observed with DMBA treatment, but none were observed with MNNG treatment. Interestingly, thyroid cancer has been reported at higher levels in other fish species treated with MNNG (Park et al 1993). These and other chemical carcinogenesis studies demonstrate that chemical mutagens retain the ability to cause malignant transformation in zebrafish tissues.…”

Section: Cancer Models In Zebrafish Early Origins Of Zebrafish Cancermentioning

confidence: 60%

Hooked on zebrafish: insights into development and cancer of endocrine tissues

Bourque¹,

Houvras²

2011

Endocrine-Related Cancer

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Zebrafish is emerging as a unique model organism for studying cancer genetics and biology. For several decades zebrafish have been used to study vertebrate development, where they have made important contributions to understanding the specification and differentiation programs in many tissues. Recently, zebrafish studies have led to important insights into thyroid development, and have been used to model endocrine cancer. Zebrafish possess a unique set of attributes that make them amenable to forward and reverse genetic approaches. Zebrafish embryos develop rapidly and can be used to study specific cell lineages or the effects of chemicals on pathways or tissue development. In this review, we highlight the structure and function of endocrine organs in zebrafish and outline the major achievements in modeling cancer. Our goal is to familiarize readers with the zebrafish as a genetic model system and propose opportunities for endocrine cancer research in zebrafish.

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High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus

Cited by 27 publications

References 21 publications

N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*¹

N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*¹

Review Article: Experimental Chemical Carcinogenesis in Fish

Hooked on zebrafish: insights into development and cancer of endocrine tissues

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High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus

Cited by 27 publications

References 21 publications

N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*1

N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*1

Review Article: Experimental Chemical Carcinogenesis in Fish

Hooked on zebrafish: insights into development and cancer of endocrine tissues

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Product

Resources

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N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*¹

N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Neoplasms in Medaka (Oryzias latipes)*¹