High frequency of rheumatic regional pain syndromes in first-degree relatives of patients with rheumatoid arthritis

Pérez-Barbosa, Lorena; Elizondo, Mario Alberto Garza; Vega‐Morales, David; Esquivel-Valerio, Jorge Antonio; Peláez‐Ballestas, Ingris; Vázquez-Fuentes, Brenda Roxana; Galarza‐Delgado, Dionicio Ángel

doi:10.1007/s10067-020-05029-z

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic risk includes a family history of RA, especially having a first-degree relative (FDR; parent, sibling, or child) with RA, which confers a 2-to 3-fold increased likelihood of developing RA compared to the general population. FDRs also express increased levels of rheumatic regional pain syndromes and RA-related autoantibodies such as ACPA and rheumatoid factor (RF) in comparison to the general population, which may be indicative of even further progression to clinical RA [60]. Other genetic risk factors include presence of the HLA-DRB1 "shared epitope", which is the strongest genetic risk factor for RA, particularly when combined with smoking and other environmental factors.…”

Section: Ra At-risk Group 2: Geneticsmentioning

confidence: 99%

Challenges and Opportunities of Targeted Behavioral Interventions for Groups at Risk for Developing Rheumatoid Arthritis

Zaccardelli

2021

Healthcare

View full text Add to dashboard Cite

Background: Rheumatoid arthritis (RA) is a serious autoimmune disease which causes painful, swollen joints and can impact quality of life and increase morbidity and mortality. There are several preclinical stages of RA that correspond to at-risk groups that include: genetic risk, risk from behaviors, elevation of RA-related autoantibodies, and early clinical disease manifestations such as undifferentiated arthritis. Early interventions are crucial to slowing progression to and potentially preventing RA onset. Modification of behaviors among at-risk individuals may decrease RA risk. There are several challenges and opportunities in implementing preventative behavioral interventions, which may vary within different at-risk groups. Methods: We performed a narrative review of the literature, including meta-analyses focused on RA risk-related behaviors as well as publications investigating the potential efficacy of behavioral modifications on RA risk. Results: There are multiple behavioral risk factors associated with RA, including smoking, obesity, low physical activity, low quality diet, and poor dental hygiene, which may contribute to progression to clinical RA. Meta-analyses have been performed for smoking, excess body weight, and physical activity. Likelihood of adopting behavioral modifications may increase as RA risk increases. Conclusions: Clinicians may be able to tailor preventative approaches to various RA at-risk groups to help reduce RA risk, but further research is needed. A better understanding of the relationship of behaviors with RA risk and optimized approaches to implementing behavioral changes may allow for clinicians to tailor their preventative approaches for at-risk individuals.

show abstract

Section: Ra At-risk Group 2: Geneticsmentioning

confidence: 99%

Challenges and Opportunities of Targeted Behavioral Interventions for Groups at Risk for Developing Rheumatoid Arthritis

Zaccardelli

2021

Healthcare

View full text Add to dashboard Cite

show abstract

Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis

et al. 2021

View full text Add to dashboard Cite

Objective The events that occur prior to the onset of rheumatoid arthritis (RA) continue to be delineated. We examined the relationship between self-reported joint symptoms, functional disability, and anticitrullinated protein antibody (ACPA) status in a cohort of first-degree relatives (FDR) of patients with RA who are at risk of future disease development. Methods We studied a cohort of 279 FDR of First Nations (FN) patients with RA who are at increased risk for future RA development, and analyzed data collected at their enrollment study visit. In parallel, we analyzed data from 279 FN subjects with no family history of RA. A subset of FDR developed inflammatory arthritis and we analyzed longitudinal data in this group. Results The prevalence of joint symptoms and functional disability was higher in FDR compared to non-FDR (all P < 0.001). Difficulty walking (37.3% vs 18.0%) and modified Health Assessment Questionnaire (HAQ) results were higher in ACPA-positive FDR compared to ACPA-negative FDR, and HAQ was independently associated with ACPA seropositivity (OR 2.79, 95% CI 1.56–5.00). Longitudinally, in individuals who developed ACPA-positive RA, ACPA level and HAQ score were significantly associated (R = 0.45, P < 0.001) in the preclinical period. Conclusion Compared to population-based controls, FDR have a high burden of joint symptoms and functional disability. Functional disability was most closely associated with ACPA seropositivity in the FDR, suggesting a direct role for ACPA outside of the context of clinically detectable synovitis. HAQ appears to be particularly valuable in the assessment of individuals at risk for future RA development.

show abstract

High frequency of rheumatic regional pain syndromes in first-degree relatives of patients with rheumatoid arthritis

Cited by 2 publications

References 18 publications

Challenges and Opportunities of Targeted Behavioral Interventions for Groups at Risk for Developing Rheumatoid Arthritis

Challenges and Opportunities of Targeted Behavioral Interventions for Groups at Risk for Developing Rheumatoid Arthritis

Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis

Contact Info

Product

Resources

About