High frequency of HLA‐A*0207 subtype in Chinese population

Abstract

HLA-A*0207 is the most common HLA-A2 subtype among Chinese. The high frequency of the HLA-A*0207 allele in this population offers a unique opportunity to study the ways in which different HLA-A2 subtypes may influence the clinical outcome of allograft transplantation and the disease susceptibility of recipients.

Screening and Identification of Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific CTL Epitopes

“…HLA-A2 is the most common HLA-A allele in Asian populations, particularly in the Chinese, with an estimated frequency of ϳ50%. It is also the most extensively studied HLA class I molecule (38). We first applied bioinformatics to predict possible CTL epitopes and followed by refolding these predicted peptides with HLA-A*0201 and ␤2 microglobulin (␤ 2 m) molecules.…”

Identification of an HLA-A*0201–restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein

“…HLA-A2 is the most common HLA-A allele in Asian populations, particularly in the Chinese, with an estimated frequency of more than 50%. 18 As SARS affected many parts of Asia, and a reservoir of infection may persist in these regions, the identification of HLA-A*0201-restricted CTL epitopes of SARS-CoV is an important contribution to future studies concerning the role of CTLs in SARS-CoV pathogenesis and protection in at-risk populations.Here we have studied a panel of SARS-CoV spike protein (SARS/S)-derived peptides to identify those with binding motifs for HLA-A*0201 molecules. We evaluated the ability of HLA-A*0201 binding peptides to provoke in vivo-and in vitro-specific CTL responses in HLA-A2.1/K b transgenic (Tg) mice and peripheral blood lymphocyte (PBL) preparations from MHC-matched healthy donors, using dendritic cells (DCs) prepulsed with the peptides.…”

Identification of HLA-A*0201-restricted CD8+ T-cell epitope C64–72 from hepatitis B virus core protein

“…Since HLA-A2 is one of the most common types of human leukocyte antigen [16], identification of new HLA-A2-restricted HBVspecific CTL epitopes is useful in developing peptide-based therapeutics vaccine against viral infections. HBV core antigen (HBcAg) is an intracellular protein which plays an important role in the maturation of the virus via encapsulating the viral DNA [18].…”

“…It has been well known that most antigenic peptides bound to MHC class I molecules possess a motif sequence with conserved allele-specific anchor residues, such as HLA-A2, -A3, -A11, -A24, B7, and -B51 supertypes, among these HLA-A2 is one of the most common types of human leukocyte antigen, which is expressed in approximately 50% of people reside in China [16] and in the North American population [17]. Identification of HLA-A2-restricted HBVspecific CTL epitopes is necessary for vaccine development and for studies of immunopathogenesis in chronic hepatitis.…”