High frequency of hepatitis B virus infection in patients with β‐thalassemia receiving multiple transfusions

Singh, Harpreet; Pradhan, Manik; Singh, R. L.; Phadke, Sobha; Aggarwal, Rakesh; Naik, S. R.

doi:10.1046/j.1423-0410.2003.00300.x

Cited by 50 publications

(50 citation statements)

References 33 publications

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“…In this study, occult hepatitis B infection detected by HBV-DNA testing constituted 32.4% of thalassemic children, which is similar to results from India [9] Table 3. Comparison between HCV-RNA, HBV-DNA and ANA of thalassemic patients included in the study in relation to age groups P-value is significant if < 0.05* Table 4.…”

Section: Discussionsupporting

confidence: 89%

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Occult hepatitis B in Egyptian thalassemic children

Shaker

Ahmed²,

Satar

et al. 2011

J Infect Dev Ctries

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Introduction: Thalassemia is hereditary anemia which requires lifelong transfusion as treatment, and hepatitis viral infection is one of the risks of repeated transfusions. Hepatitis B outbreaks in health-care settings are still a serious public health concern worldwide. Blood samples negative for HBsAg but positive for HBV-DNA, with or without the presence of HBV antibodies, are classified as "occult" HBV infection (OBI). This study investigated the prevalence of occult HBV infection in Egyptian thalassemic children. Methodology: Eighty patients admitted to the Faculty of Medicine, Cairo University Hospital, were involved in this prospective study. Strict inclusion criteria were set to nullify the effect of confounding variables and further minimize selection bias. The following laboratory investigations were performed: complete blood count (CBC); serum AST and ALT; albumin; bilirubin; HBsAg; HBeAg; HBcAb; HCV-RNA; and HBV-DNA. Results: All our patients had no clinical manifestation suggestive of hepatitis. Molecular biology studies revealed positivity for HCV and HBV at 25% and 32.5% respectively. Conclusion: The estimated risk of acquiring hepatitis B and C infection in children receiving multiple blood transfusions is surprisingly high. Moreover, occult hepatitis B infection is a considerably risk.

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Section: Discussionsupporting

confidence: 89%

“…The true burden of HBV infection in the thalassemic population, using the more sensitive molecular detection methods, has not been estimated [9].…”

Section: Discussionmentioning

confidence: 99%

Occult hepatitis B in Egyptian thalassemic children

Shaker

Ahmed²,

Satar

et al. 2011

J Infect Dev Ctries

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“…Similar results were found in studies in Jordon and Iran with measured HBsAg prevalence being 3.5% and 1.5% respectively indicating vaccination against Hepatitis B decreases the incidence of HBsAg positivity. 22 The low incidence of HBsAg positivity could be due to development of good antibody titre after vaccination. Ideally, a minimum of two doses of vaccination should be given before starting transfusion in a newly diagnosed thalassemia case.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis B and hepatitis C virus infection in repeatedly transfused thalassemics in a tertiary care hospital in eastern India

2017

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Background: Patients of thalassemia who are conventionally treated by a regular transfusion regimen are at a risk of developing transfusion transmissible infections, including hepatitis. The present study was conducted to assess the prevalence of hepatitis B and hepatitis C virus infections among repeatedly transfused thalassemia patients.Methods: A total of 207 patients of beta-thalassemia, who had received at least 10 transfusions were tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibody using enzyme linked immunosorbant assay (ELISA).Results: The overall number of anti-hepatitis C antibody seropositive was 51 (24.6%) and that for hepatitis B surface antigen positives was 7 (3.38%). The prevalence rate for hepatitis B surface antigen was in agreement with average national values, but in case of anti-HCV antibodies the prevalence rate values were comparatively much higher.Conclusions: Stringent measures need to be taken on urgent basis while screening blood for anti-hepatitis C antibody and hepatitis B surface antigen including inclusion of other sensitive assay like nucleic acid test (NAT) as well as better donor recruitment.

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“…The prevalence of HBV infection reported by various authors from India ranges from 2 to 69.2%. [74][75][76][77] An earlier report of 1995 had shown that 69.2% of thalassemic patients had HBV infection. 74 However, subsequent reports have however shown a lower prevalence of HBV infection in thalassemics.…”

Section: Transfusion Of Blood and Blood Productsmentioning

confidence: 99%

Tackling the Hepatitis B Disease Burden in India

Puri

2014

Journal of Clinical and Experimental Hepatology

119

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Globally, approximately 240 people have been infected worldwide with hepatitis B Virus (HBV). India has approximately HBV carrier rate of 3.0% with a high prevalence rate in the tribal population. With a population of more than 1.25 billion, India has more than 37 million HBV carriers and contributes a large proportion of this HBV burden. While horizontal transmission in childhood appears to be a major route of transmission, the role of vertical transmission is probably underestimated. Blood transfusion and unsafe therapeutic injections continue to be important modes of transmission of HBV. There is a need for large field studies to better understand HBV epidemiology and identify high prevalence areas, and public health measures to prevent disease transmission and decrease the burden of the disease. ( J CLIN EXP HEPATOL 2014;4:312-319)

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High frequency of hepatitis B virus infection in patients with β‐thalassemia receiving multiple transfusions

Cited by 50 publications

References 33 publications

Occult hepatitis B in Egyptian thalassemic children

Occult hepatitis B in Egyptian thalassemic children

Prevalence of hepatitis B and hepatitis C virus infection in repeatedly transfused thalassemics in a tertiary care hospital in eastern India

Tackling the Hepatitis B Disease Burden in India

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