High frequency of HBV in HIV-infected prisoners in Mozambique

Augusto, Ângelo; Augusto, Orvalho; Taquibo, Atija; Nhachigule, Carina; Siyawadya, Narcisa; Gudo, Eduardo Samo

doi:10.1108/ijph-11-2017-0056

Cited by 3 publications

(4 citation statements)

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“…Population-based studies conducted in Mozambique have reported HBV infection rates of 11.4% in prisoners [ 15 ], 13.2% in refugees [ 16 ], 4.5% to 9.3% in blood donors [ 17 , 18 ], 5.9% to 32.8% in persons who use drugs [ 19 ], 12.2% in young adults [ 13 ], 7.6% in HIV-positive adults initiating antiretroviral therapy [ 20 ], and 4.0% in pregnant women [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Like other Southern African countries, Mozambique is considered endemic for HBV [ 13 , 14 ]. Population-based studies conducted in Mozambique have reported HBV infection rates of 11.4% in prisoners [ 15 ], 13.2% in refugees [ 16 ], 4.5% to 9.3% in blood donors [ 17 , 18 ], 5.9% to 32.8% in persons who use drugs [ 19 ], 12.2% in young adults [ 13 ], 7.6% in HIV-positive adults initiating antiretroviral therapy [ 20 ], and 4.0% in pregnant women [ 21 ]. Most studies of HBV in Mozambique have been conducted in the capital city of Maputo, and information regarding viral diversity in the other regions of the country is scarce.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis B virus genotypes and drug resistance mutations circulating in blood donors in Beira, Mozambique

et al. 2023

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Hepatitis B virus (HBV) infects nearly 300 million people and is the leading cause of hepatitis and hepatocellular carcinoma worldwide. Despite the high burden of HBV in sub-Saharan Africa, countries such as Mozambique have limited data available on circulating HBV genotypes and the presence of drug resistance mutations. Blood donors from Beira, Mozambique were tested for HBV surface antigen (HBsAg) and HBV DNA at the Instituto Nacional de Saúde in Maputo, Mozambique. Regardless of HBsAg status, donors with detectable HBV DNA were evaluated for HBV genotype. PCR was performed with primers amplifying a 2.1–2.2 kilobase fragment of the HBV genome. PCR products were submitted for next generation sequencing (NGS), and consensus sequences were evaluated for HBV genotype, recombination, and the presence or absence of drug resistance mutations. Of the 1281 blood donors tested, 74 had quantifiable HBV DNA. The polymerase gene could be amplified from 45 of 58 (77.6%) individuals with chronic HBV infection and 12 of 16 (75%) with occult HBV infection. Among these 57, 51 (89.5%) sequences belonged to HBV genotype A1, while 6 (10.5%) were HBV genotype E. All genotype E sequences were E/A recombinants, and clustered separately from other genotype E references. Genotype A samples had a median viral load of 637 IU/mL, while genotype E samples had a median viral load of 476,084 IU/mL. No drug resistance mutations were observed in the consensus sequences. The current study demonstrates the genotypic diversity of HBV in blood donors in Mozambique, but the absence of dominant (consensus) drug resistance mutations. Studies in other at-risk populations are essential for understanding the epidemiology, risk of liver disease, and likelihood of treatment resistance in resource-limited settings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus genotypes and drug resistance mutations circulating in blood donors in Beira, Mozambique

et al. 2023

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“…One study reported the prevalence of HBV/HIV as 15% in Africa [ 64 ]. However, there is limited data on the HBV/HIV co-infection in the African region, as only about 2% of prisoners are tested for HBV (before or during incarceration) in the region [ 83 ]. Also, only 14% of African prisoners have heard about hepatitis before being incarcerated, and HBV screening or vaccination is not a routine procedure in the prisons of this region [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although limited data is available on the frequency and dynamics of risky sexual activities in detention centers and jails, it is suggested that, in the absence of access to condom and lubricants, sex for pleasure or in exchange for drug, money, personal protection, food, or other goods is common in prisons and this risky behavior is even more common among prisoners with HIV [ 3 , 83 ].…”

Section: Discussionmentioning

confidence: 99%

The global and regional prevalence of hepatitis C and B co-infections among prisoners living with HIV: a systematic review and meta-analysis

et al. 2021

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Background Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are common among individuals with human immune deficiency virus (HIV) infection worldwide. In this study, we did a systematic review and meta-analysis of the published literature to estimate the global and regional prevalence of HCV, HBV and HIV coinfections among HIV-positive prisoners. Methods We searched PubMed via MEDLINE, Embase, the Cochrane Library, SCOPUS, and Web of science (ISI) to identify studies that reported the prevalence of HBV and HCV among prisoners living with HIV. We used an eight-item checklist for critically appraisal studies of prevalence/incidence of a health problem to assess the quality of publications in the included 48 cross-sectional and 4 cohort studies. We used random-effect models and meta-regression for the meta-analysis of the results of the included studies. Results The number of the included studies were 50 for HCV-HIV, and 23 for HBV-HIV co-infections. The pooled prevalence rates of the coinfections were 12% [95% confidence interval (CI) 9.0–16.0] for HBV-HIV and 62% (95% CI 53.0–71.0) for HCV-HIV. Among HIV-positive prisoners who reported drug injection, the prevalence of HBV increased to 15% (95% CI 5.0–23.0), and the HCV prevalence increased to 78% (95% CI 51.0–100). The prevalence of HBV-HIV coinfection among prisoners ranged from 3% in the East Mediterranean region to 27% in the American region. Also, the prevalence of HCV-HIV coinfections among prisoners ranged from 6% in Europe to 98% in the East Mediterranean regions. Conclusions Our findings suggested that the high prevalence of HBV and HCV co-infection among HIV-positive prisoners, particularly among those with a history of drug injection, varies significantly across the globe. The results of Meta-regression analysis showed a sliding increase in the prevalence of the studied co-infections among prisoners over the past decades, rising a call for better screening and treatment programs targeting this high-risk population. To prevent the above coinfections among prisoners, aimed public health services (e.g. harm reduction via access to clean needles), human rights, equity, and ethics are to be seriously delivered or practiced in prisons. Protocol registration number: CRD42018115707 (in the PROSPERO international). Graphic abstract

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Research on High-Frequency Information-Transmission Method of Smart Grid Based on CNN-LSTM Model

Chen

2022

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In order to solve the problem of the slow transmission rate of high-frequency information in smart grid and improve the efficiency of information transmission, a research method of high-frequency information transmission in smart grids based on the CNN-LSTM model is proposed. It effectively combines the superiority of the CNN algorithm for high-frequency information feature extraction and the learning ability of the LSTM algorithm for global features of high-frequency information. Meanwhile, the client buffer is divided by the VLAN area division method, which avoids the buffer being too large due to line congestion. The intelligent control module is adopted to change the traditional control concept. In addition, the neural network optimization control module is used for intelligent control, which ensures the feedback speed of the control terminal and avoids the problem of increasing the buffer area caused by the feedback time difference. The experimental results show that via the method in this paper, the total efficiency of single-channel transmission reaches 96% and the transmission rate reaches 46 bit/s; the total efficiency of multiplex transmission is 89% and the transmission rate reaches 75 bit/s. It is verified that the method proposed in this paper has a fast transmission rate and high efficiency.

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High frequency of HBV in HIV-infected prisoners in Mozambique

Cited by 3 publications

References 19 publications

Hepatitis B virus genotypes and drug resistance mutations circulating in blood donors in Beira, Mozambique

Hepatitis B virus genotypes and drug resistance mutations circulating in blood donors in Beira, Mozambique

The global and regional prevalence of hepatitis C and B co-infections among prisoners living with HIV: a systematic review and meta-analysis

Research on High-Frequency Information-Transmission Method of Smart Grid Based on CNN-LSTM Model

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