High frequency of coagulase-positive staphylococci carriage in healthy wild boar with detection of MRSA of lineage ST398-t011

Mama, Olouwafemi Mistourath; Ruiz-Ripa, Laura; Fernández-Fernández, Rosa; González‐Barrio, David; Ruiz‐Fons, Francisco; Torres, Carmén

doi:10.1093/femsle/fny292

Cited by 19 publications

(20 citation statements)

References 47 publications

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“…A high S. aureus carriage rate was detected in wild boars (65%), which is in accordance with previous data obtained in Portugal and Germany (Sousa et al 2017;Seinige et al 2017), although lower colonization rates were also reported in other studies (Porrero et al 2014;Mama et al 2019). Although the lineage MRSA CC398 has been reported in wild boar (Porrero et al 2013;Sousa et al 2017;Mama et al 2019), the presence of MRSA isolates in this animal species is scarce, as has been evidenced in our study. It is important to highlight that the four European mouflons tested were S. aureus-carriers and three of the four isolates recovered were typed as t6056-ST133.…”

Section: Discussionsupporting

confidence: 92%

“…There are several spa ‐types that seem to be widely spread in wild mammals, like in the case of t7174, t6386, t3750, t11230 and t11233, as previously reported in Spain (Porrero et al ). The spa t3750 (ST2328), detected in three of the 11 MSSA isolates of wild boar, was the most prevalent spa ‐type among MSSA in this animal species in previous studies conducted in Spain and Portugal (Porrero et al ; Sousa et al ; Mama et al ). The clonal complex CC133 has been detected in the isolates recovered from European mouflon.…”

Section: Discussionmentioning

confidence: 86%

“…Previous studies performed in Spain, some of them by our group, have determined the prevalence and characteristics of S. aureus isolates in different wild mammals and from different geographic regions (Porrero et al 2013;Porrero et al 2014;G omez et al 2014;Mama et al 2019). In these studies, animals from Arag on, a geographic region located in the North of Spain, were scarcely represented (Porrero et al 2013;Porrero et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Diversity ofStaphylococcus aureusclones in wild mammals in Aragon, Spain, with detection of MRSA ST130‐mecCin wild rabbits

et al. 2019

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Aims To determine the Staphylococcus aureus carriage rate in wild mammals in Aragon, northern Spain, to analyse their antimicrobial resistance phenotype/genotype and to characterize the recovered isolates. Methods and Results Nasal and rectal swabs of 103 mammals were collected in Aragón during the period 2012–2015. Antimicrobial susceptibility, the presence of antimicrobial resistance genes and virulence factors were investigated. Molecular characterization was carried out by spa, MLST, agr and SCCmec. Staphylococcus aureus were recovered from 23 animals (22%). Four of the 23 S. aureus were methicillin‐resistant S. aureus (MRSA). Three MRSA were mecC‐positive and were isolated from European rabbits and were typed as t843 (ascribed to CC130). The remaining MRSA was a mecA‐carrying isolate from European hedgehog, typed as ST1‐t386‐SCCmecIVa‐agrIII and it harboured the blaZ, erm(C), ant(6)‐Ia and aph(3´)‐IIIa resistance genes. A high diversity of spa‐types was detected among the 19 methicillin‐susceptible S. aureus isolates, which showed high susceptibility to the antimicrobials tested. The tst gene and different combinations of staphylococcal enterotoxins were found. Conclusions Staphylococcus aureus were detected in nasal and rectal samples of wild mammals. Wild rabbits could be a reservoir of mecC‐MRSA. Significance and Impact of the Study This work provides information on the presence and characteristics of S. aureus from mammals in a defined geographic region in Spain.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Diversity ofStaphylococcus aureusclones in wild mammals in Aragon, Spain, with detection of MRSA ST130‐mecCin wild rabbits

et al. 2019

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“…Twenty-two different spa types and eight STs were detected among the MSSA. The only MRSA strain was ascribed to CC398 and spa-type t011, and showed resistance to penicillin and tetracycline, harboring the blaZ, mecA, tet(M) and tet(K) genes [137].…”

Section: S Aureus and Mrsa In Wild Animalsmentioning

confidence: 99%

Molecular Epidemiology of Staphylococcus aureus Lineages in Wild Animals in Europe: A Review

et al. 2020

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Staphylococcus aureus is an opportunist pathogen that is responsible for numerous types of infections. S. aureus is known for its ability to easily acquire antibiotic resistance determinants. Methicillin-resistant S. aureus (MRSA) is a leading cause of infections both in humans and animals and is usually associated with a multidrug-resistant profile. MRSA dissemination is increasing due to its capability of establishing new reservoirs and has been found in humans, animals and the environment. Despite the fact that the information on the incidence of MRSA in the environment and, in particular, in wild animals, is scarce, some studies have reported the presence of these strains among wildlife with no direct contact with antibiotics. This shows a possible transmission between species and, consequently, a public health concern. The aim of this review is to better understand the distribution, prevalence and molecular lineages of MRSA in European free-living animals.

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“…CC49 strains show a less diverse host spectrum and have mostly been isolated from wild animals such as bank voles, squirrels and wild boar in Central Europe and Spain [10,11,[51][52][53]. Usually, these isolates show an MSSA phenotype, but MRSA (both mecA and mecC positive) were also found in pigs, horses, and humans [54][55][56].…”

Section: Wild Rats Are Predominantly Colonized With the S Aureus Linmentioning

confidence: 99%

Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population

Raafat

Mrochen

Al’Sholui

et al. 2020

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Rats are a reservoir of human- and livestock-associated methicillin-resistant Staphylococcus aureus (MRSA). However, the composition of the natural S. aureus population in wild and laboratory rats is largely unknown. Here, 144 nasal S. aureus isolates from free-living wild rats, captive wild rats and laboratory rats were genotyped and profiled for antibiotic resistances and human-specific virulence genes. The nasal S. aureus carriage rate was higher among wild rats (23.4%) than laboratory rats (12.3%). Free-living wild rats were primarily colonized with isolates of clonal complex (CC) 49 and CC130 and maintained these strains even in husbandry. Moreover, upon livestock contact, CC398 isolates were acquired. In contrast, laboratory rats were colonized with many different S. aureus lineages—many of which are commonly found in humans. Five captive wild rats were colonized with CC398-MRSA. Moreover, a single CC30-MRSA and two CC130-MRSA were detected in free-living or captive wild rats. Rat-derived S. aureus isolates rarely harbored the phage-carried immune evasion gene cluster or superantigen genes, suggesting long-term adaptation to their host. Taken together, our study revealed a natural S. aureus population in wild rats, as well as a colonization pressure on wild and laboratory rats by exposure to livestock- and human-associated S. aureus, respectively.

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High frequency of coagulase-positive staphylococci carriage in healthy wild boar with detection of MRSA of lineage ST398-t011

Cited by 19 publications

References 47 publications

Diversity ofStaphylococcus aureusclones in wild mammals in Aragon, Spain, with detection of MRSA ST130‐mecCin wild rabbits

Diversity ofStaphylococcus aureusclones in wild mammals in Aragon, Spain, with detection of MRSA ST130‐mecCin wild rabbits

Molecular Epidemiology of Staphylococcus aureus Lineages in Wild Animals in Europe: A Review

Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population

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