High-Frequency Nonlinear Doppler Contrast-Enhanced Ultrasound Imaging of Blood Flow

Bruce, Matthew; Hannah, Alex; Hammond, Ryan; Khaing, Zin Z.; Tremblay-Darveau, Charles; Burns, Peter N.; Hofstetter, Christoph P.

doi:10.1109/tuffc.2020.2986486

Cited by 27 publications

(37 citation statements)

References 24 publications

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“…It is possible to separate vessels within a region based on their blood velocity using highfrequency ultrasound and novel Doppler processing. 69 This could help confirm on the whole-tumor scale which vessels are more sensitive to the effects of ultrasound and microbubbles. In addition to IFP measurements and histology, a clearer picture of the mechanism might be possible.…”

Section: ■ Elevated Interstitial Fluid Pressure Within the Tumor Extr...mentioning

confidence: 96%

“…With the advent of super-resolution contrast imaging, it may be possible to further investigate this vascular selectivity using imaging techniques. It is possible to separate vessels within a region based on their blood velocity using high-frequency ultrasound and novel Doppler processing . This could help confirm on the whole-tumor scale which vessels are more sensitive to the effects of ultrasound and microbubbles.…”

Section: Role Of Ultrasound In Modulating Interstitial Fluid Pressure...mentioning

confidence: 99%

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The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

Keller

Averkiou

2021

Bioconjugate Chem.

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The unique microenvironment of solid tumors, including desmoplasia within the extracellular matrix, enhanced vascular permeability, and poor lymphatic drainage, leads to an elevated interstitial fluid pressure which is a major barrier to drug delivery. Reducing tumor interstitial fluid pressure is one proposed method of increasing drug delivery to the tumor. The goal of this topical review is to describe recent work using focused ultrasound with or without microbubbles to modulate tumor interstitial fluid pressure, through either thermal or mechanical effects on the extracellular matrix and the vasculature. Furthermore, we provide a review on techniques in which ultrasound imaging may be used to diagnose elevated interstitial fluid pressure within solid tumors. Ultrasound-based techniques show high promise in diagnosing and treating elevated interstitial pressure to enhance drug delivery.

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Section: ■ Elevated Interstitial Fluid Pressure Within the Tumor Extr...mentioning

confidence: 96%

Section: Role Of Ultrasound In Modulating Interstitial Fluid Pressure...mentioning

confidence: 99%

The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

Keller

Averkiou

2021

Bioconjugate Chem.

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“…Still, the Doppler mode mainly demonstrates tissue perfusion, including allowing assessing stenosis or a lack of flow of large arteries up to 200 mm in diameter. 64 In harmonic imaging, also called non-linear scattering response, which employs a specific frequency (e.g., 1F), the microbubbles contrasts will have non-linear contraction and expansion. In contrast, the surrounding tissues have regular oscillation, resulting in receiving waves 2F in frequency.…”

Section: Materials Advances Reviewmentioning

confidence: 99%

Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

et al. 2022

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“…Ultrasound contrast agents (UCAs) that strongly reflect ultrasound waves were developed to overcome poor native contrast and have become ubiquitous in clinics for organ perfusion imaging and echocardiography. [ 1,2 ] Microbubbles with a gas core and a soft shell have attracted particular interest as UCAs because their nonlinear contributions to reflected ultrasound signals allow more sensitive detection. [ 3–6 ] Lipids, already extensively applied in drug delivery systems, are the materials predominantly employed for these synthetic soft shells.…”

Section: Introductionmentioning

confidence: 99%

“…DOI: 10.1002/smll.202107143 imaging and echocardiography. [1,2] Microbubbles with a gas core and a soft shell have attracted particular interest as UCAs because their nonlinear contributions to reflected ultrasound signals allow more sensitive detection. [3][4][5][6] Lipids, already extensively applied in drug delivery systems, are the materials predominantly employed for these synthetic soft shells.…”

mentioning

confidence: 99%

Engineering Responsive Ultrasound Contrast Agents Through Crosslinked Networks on Lipid‐Shelled Microbubbles

Dubey

Christiansen

Vizovišek

et al. 2022

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Ultrasound imaging with contrast agents, especially with lipid‐shelled microbubbles, has become a vital tool in clinical diagnostics. Efforts to adapt these agents for molecular imaging have typically focused on targeted binding. More recently, crosslinking the lipid shell to alter its mechanical properties, followed by decrosslinking upon exposure to a stimulus, has been shown as a promising approach for imaging soluble molecular targets. Nevertheless, a systematic study of the influence of crosslinker concentration and structure on the mechanical properties of microbubbles has not been undertaken. An improved understanding of the role of these parameters is necessary to more effectively design contrast agents that detect proteases, an informative class of soluble disease markers. Here, the influence of crosslinker parameters on the acoustic properties of microbubbles, developing a model of crosslinker network formation on microbubble shells that explains the experimental observations, are studied. By incorporating cleavable elements that respond to UV light or proteolysis, kinetically resolved acoustic detection of these stimuli and the relevance of crosslinker design are demonstrated. The framework established in this study can be readily adapted to other protease‐cleavable units and provides a basis for the future development of responsive ultrasound contrast agents for molecular imaging of proteolytic activity.

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High-Frequency Nonlinear Doppler Contrast-Enhanced Ultrasound Imaging of Blood Flow

Cited by 27 publications

References 24 publications

The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

Engineering Responsive Ultrasound Contrast Agents Through Crosslinked Networks on Lipid‐Shelled Microbubbles

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