High-Frequency, Long-Range Coupling Between Prefrontal and Visual Cortex During Attention

Gregoriou, Georgia G.; Gotts, Stephen J.; Zhou, Huihui; Desimone, Robert

doi:10.1126/science.1171402

Cited by 1,126 publications

(1,207 citation statements)

References 27 publications

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“…As a consequence, postsynaptic neuronal groups would receive spatially and temporally dense excitation, triggering a new chain of taskselective spiking output and potentially allowing to synchronize distant nodes of larger cognitive control network to a common underlying theta-rhythm. Although this scenario awaits to be tested directly, previous studies suggest that selective synchronization at theta-and/or higher γ-band frequencies among neuronal groups is indeed used by the brain to integrate and rapidly distribute task-relevant information (59,60). One interesting speculation relates the observed LFP thetaactivity in the ACC to theta-activity recorded from the frontal midline in human EEG/MEG studies.…”

Section: Discussionmentioning

confidence: 99%

Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors

Womelsdorf

Johnston

Vinck

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

211

153

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Accomplishing even simple tasks depend on neuronal circuits to configure how incoming sensory stimuli map onto responses. Controlling these stimulus-response (SR) mapping rules relies on a cognitive control network comprising the anterior cingulate cortex (ACC). Single neurons within the ACC convey information about currently relevant SR mapping rules and signal unexpected action outcomes, which can be used to optimize behavioral choices. However, its functional significance and the mechanistic means of interaction with other nodes of the cognitive control network remain elusive and poorly understood. Here, we report that core aspects of cognitive control are encoded by rhythmic theta-band activity within neuronal circuits in the ACC. Throughout task performance, theta-activity predicted which of two SR mapping rules will be established before processing visual target information. Task-selective theta-activity emerged particularly early during those trials, which required the adjustment of SR rules following an erroneous rule representation in the preceding trial. These findings demonstrate a functional correlation of cognitive control processes and oscillatory theta-band activity in macaque ACC. Moreover, we report that spike output of a subset of cells in ACC is synchronized to predictive theta-activity, suggesting that the theta-cycle could serve as a temporal reference for coordinating local task selective computations across a larger network of frontal areas and the hippocampus to optimize and adjust the processing routes of sensory and motor circuits to achieve efficient sensory-motor control.cognitive control | theta-synchronization | attention | oscillation | antisaccade C ognitive control refers to those neuronal processes responsible for assembling task-relevant information, which in turn biases sensory and motor pathways for efficient communication during task processing. Two core functions of cognitive control are (i) the implementation and maintenance of task-relevant stimulusresponse (SR) mapping rules, and (ii) the adjustment and optimization of such representations during task performance according to behavioral outcome. Both functions are subserved by a mosaic of interconnected neuronal groups distributed within frontal cortex (1-4). The anterior cingulate cortex (ACC) is one of the key nodes within this cognitive control network, conveying task relevant information at various time intervals during task processing (5, 6). First, during preparatory periods, ACC neurons convey signals selective for the currently relevant SR mapping rule (7), and allow inferences with respect to changes in SR mapping triggered by either an incorrect response, or an explicit cue to change SR mapping (8). Second, during stimulus processing and delay epochs in working memory paradigms, subsets of neurons encode the expected reward outcome associated with the stimulus (9). Third, following the behavioral response to a target stimulus, neuronal groups in ACC signal whether the behavioral response was incorrect or result...

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Section: Discussionmentioning

confidence: 99%

Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors

Womelsdorf

Johnston

Vinck

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

211

153

View full text Add to dashboard Cite

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“…Some forms of dynamic grouping require attention, and it has been shown that attention strongly enhances gamma-band synchronization both within (Fries et al, 2001b) and between cortical regions (Gregoriou et al, 2009). Furthermore, in addition to any role that it has in grouping, attention may also affect amplification and suppression via its effect on the synchrony of inhibitory interneuron activities.…”

Section: Modulation That Synchronizes Responses To Rf Inputmentioning

confidence: 99%

On the functions, mechanisms, and malfunctions of intracortical contextual modulation

Phillips

Clark

Silverstein

2015

Neuroscience & Biobehavioral Reviews

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A broad neuron-centric conception of contextual modulation is reviewed and re-assessed in the light of recent neurobiological studies of amplification, suppression, and synchronization. Behavioural and computational studies of perceptual and higher cognitive functions that depend on these processes are outlined, and evidence that those functions and their neuronal mechanisms are impaired in schizophrenia is summarized. Finally, we compare and assess the long-term biological functions of contextual modulation at the level of computational theory as formalized by the theories of coherent infomax and free energy reduction. We conclude that those theories, together with the many empirical findings reviewed, show how contextual modulation at the neuronal level enables the cortex to flexibly adapt the use of its knowledge to current circumstances by amplifying and grouping relevant activities and by suppressing irrelevant activities.

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“…Simultaneous recording from multiple intracortical areas in monkeys showed that the coherent higher frequency (beta and gamma bands) oscillations are linked to a broad variety of cognitive functions (12)(13)(14)(15)(16)(17)(18). Cortical oscillations at lower frequencies (theta and alpha bands) have also been discussed in terms of long-range integrative processes (19,20).…”

mentioning

confidence: 99%

Coherent delta-band oscillations between cortical areas correlate with decision making

Nácher

Ledberg

Deco

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

136

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Coherent oscillations in the theta-to-gamma frequency range have been proposed as a mechanism that coordinates neural activity in large-scale cortical networks in sensory, motor, and cognitive tasks. Whether this mechanism also involves coherent oscillations at delta frequencies (1-4 Hz) is not known. Rather, delta oscillations have been associated with slow-wave sleep. Here, we show coherent oscillations in the delta frequency band between parietal and frontal cortices during the decision-making component of a somatosensory discrimination task. Importantly, the magnitude of this delta-band coherence is modulated by the different decision alternatives. Furthermore, during control conditions not requiring decision making, delta-band coherences are typically much reduced. Our work indicates an important role for synchronous activity in the delta frequency band when large-scale, distant cortical networks coordinate their neural activity during decision making.synchrony | low-frequency rhythm | brain circuits

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High-Frequency, Long-Range Coupling Between Prefrontal and Visual Cortex During Attention

Cited by 1,126 publications

References 27 publications

Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors

Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors

On the functions, mechanisms, and malfunctions of intracortical contextual modulation

Coherent delta-band oscillations between cortical areas correlate with decision making

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