High frequency block of selected axons using an implantable microstimulator

Peng, Chih Wei; Chen, Jia Jin Jason; Lin, Chou Ching K.; Poon, P.W.F.; Liang, Chih-Kuo; Kang, Lin

doi:10.1016/j.jneumeth.2003.11.005

Cited by 22 publications

(8 citation statements)

References 25 publications

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“…Peng et al. evaluated asymmetric 6 kHz waves in which the first phase was shorter than the second (charge balanced maintained). They found more effective block with this waveform when compared with a purely symmetric waveform.…”

Section: Characteristics Of Khfac Blockmentioning

confidence: 99%

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Kilgore

Bhadra

2014

Neuromodulation: Technology at the Neural Interface

209

231

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Objectives The features and clinical applications of balanced-charge kilohertz frequency alternating currents (KHFAC) are reviewed. Preclinical studies of KHFAC block have demonstrated that it can produce an extremely rapid and reversible block of nerve conduction. Recent systematic analysis and experimentation utilizing KHFAC block has resulted in a significant increase in interest in KHFAC block, both scientifically and clinically. Materials and Methods We review the history and characteristics of KHFAC block, the methods used to investigate this type of block, the experimental evaluation of block, and the electrical parameters and electrode designs needed to achieve successful block. We then analyze the existing clinical applications of high frequency currents, comparing the early results with the known features of KHFAC block. Results Although many features of KHFAC block have been characterized, there is still much that is unknown regarding the response of neural structures to rapidly fluctuating electrical fields. The clinical reports to date do not provide sufficient information to properly evaluate the mechanisms that result in successful or unsuccessful treatment. Conclusions KHFAC nerve block has significant potential as a means of controlling nerve activity for the purpose of treating disease. However, early clinical studies in the use of high frequency currents for the treatment of pain have not been designed to elucidate mechanisms or allow direct comparisons to preclinical data. We strongly encourage the careful reporting of the parameters utilized in these clinical studies, as well as the development of outcome measures that could illuminate the mechanisms of this modality.

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Section: Characteristics Of Khfac Blockmentioning

confidence: 99%

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Kilgore

Bhadra

2014

Neuromodulation: Technology at the Neural Interface

209

231

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“…Although several wireless systems for animal tests have been developed, they are not perfectly suitable in our application either because of the large size (Obeid et al, 2004), the short transmission range (Peng et al, 2004), or the operating frequency that is not publicly allowed in United States (Nieder, 2000;Chien and Jaw, 2005;Schregardus et al, 2006). Nevertheless, to our best knowledge, an integrated wireless recording and stimulating system that can provide an optimized signal feedback control of the electrical stimulation has yet been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

A combined wireless neural stimulating and recording system for study of pain processing

Ativanichayaphong

Hagains

et al. 2008

Journal of Neuroscience Methods

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“…The use of high‐frequency alternating currents (HFAC), applied directly to the nerve, can produce a quick‐acting, quick‐reversing nerve block with a minimum of side effects in animals 1, 2, 9, 10, 13, 15–17, 19, 21–24. A detailed review of this literature has been recently presented elsewhere 15.…”

mentioning

confidence: 99%

High‐frequency electrical conduction block of mammalian peripheral motor nerve

2005

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A quick-acting, quick-reversing method for blocking action potentials in peripheral nerves could be used in the treatment of muscle spasticity and pain. A high-frequency alternating-current (HFAC) sinusoidal waveform is one possible means for providing this type of block. HFAC was used to block peripheral motor nerve activity in an in vivo mammalian model. Frequencies from 10 to 30 kHZ at amplitudes of between 2 and 10 V were investigated. A complete and reversible motor block was obtained at all frequencies. The block threshold amplitudes showed a linear relationship with frequency, the lowest threshold being at 10 kHZ. HFAC block has three phases: an onset response; a period of asynchronous firing; and a steady state of complete or partial block. The onset response and the asynchronous firing can be minimized by using an optimal frequency-amplitude combination. In general, the onset response was lowest for the combination of 30 kHZ and 10 V.

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High frequency block of selected axons using an implantable microstimulator

Cited by 22 publications

References 25 publications

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

A combined wireless neural stimulating and recording system for study of pain processing

High‐frequency electrical conduction block of mammalian peripheral motor nerve

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