High-Frequency and High-Field Hysteresis Loop Tracer for Magnetic Nanoparticle Characterization

Lenox, Philip; Plummer, L. Kenyon; Paul, Partha Sarathi; Hutchison, James E.; Jander, Albrecht; Dhagat, Pallavi

doi:10.1109/lmag.2017.2768521

Cited by 8 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inset of Figure 9 shows the nanoparticle size distributions that were obtained from magnetogranulometry and TEM. Several groups recently developed AC magnetometry [134,135] with the aim of determining the hysteresis loss in magnetic nanoparticles used in magnetic hyperthermia applications. The method is generally useful for characterizing the magnetic dynamic response of single and multicore magnetic nanoparticle systems at low and high frequencies in the range 1 kHz-1 MHz.…”

Section: Magnetic Propertiesmentioning

confidence: 99%

Magnetic Nanoparticle Systems for Nanomedicine—A Materials Science Perspective

et al. 2020

View full text Add to dashboard Cite

Iron oxide nanoparticles are the basic components of the most promising magneto-responsive systems for nanomedicine, ranging from drug delivery and imaging to hyperthermia cancer treatment, as well as to rapid point-of-care diagnostic systems with magnetic nanoparticles. Advanced synthesis procedures of single- and multi-core iron-oxide nanoparticles with high magnetic moment and well-defined size and shape, being designed to simultaneously fulfill multiple biomedical functionalities, have been thoroughly evaluated. The review summarizes recent results in manufacturing novel magnetic nanoparticle systems, as well as the use of proper characterization methods that are relevant to the magneto-responsive nature, size range, surface chemistry, structuring behavior, and exploitation conditions of magnetic nanosystems. These refer to particle size, size distribution and aggregation characteristics, zeta potential/surface charge, surface coating, functionalization and catalytic activity, morphology (shape, surface area, surface topology, crystallinity), solubility and stability (e.g., solubility in biological fluids, stability on storage), as well as to DC and AC magnetic properties, particle agglomerates formation, and flow behavior under applied magnetic field (magnetorheology).

show abstract

Section: Magnetic Propertiesmentioning

confidence: 99%

Magnetic Nanoparticle Systems for Nanomedicine—A Materials Science Perspective

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To characterize the heating of MNPs under various AMF conditions, we directly captured dynamic hysteresis loops of samples with a custom high-amplitude alternating current (AC) magnetometer. While previous studies have made use of AC magnetometers, [16][17][18][19][20] our instrument accessed a significantly expanded range of AMF amplitudes and frequencies (≤214 mT at 23.3 kHz, ≤153 mT at 75 kHz, ≤84.8 mT at 174.3 kHz, ≤26.2 mT at 488.5 kHz, and ≤19.5 mT at 565.4 kHz) facilitating rapid identification of MNP materials and paired driving conditions for multiplexing.…”

Section: Characterization Of Dynamic Magnetizationmentioning

confidence: 99%

“…For small working volumes, [21] such a design lowers the power required to reach relevant AMF amplitudes compared to previously reported air core designs. [16,17,20] Instead of using a pair of coaxial solenoids as sense and compensation coils as is typical, [16] our design employed a symmetric set of side-by-side spirals on a printed circuit board precisely positioned within the electromagnet gap via a printed holder (Figure 3a,b). The voltage produced by the field in the compensation coil partially canceled the field induced in the sense coil, isolating the signal arising from the time-varying magnetization of a MNP sample (Figure 3b).…”

Section: Characterization Of Dynamic Magnetizationmentioning

confidence: 99%

Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling

Moon

Christiansen

Rao

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make use of heat dissipation by ferrite nanoparticles under alternating magnetic fields, with these fields acting as an externally administered stimulus that is either present or absent, toggling heat dissipation on and off. Here, an extension of this concept, magnetothermal multiplexing is demonstrated, in which exposure to alternating magnetic fields of differing amplitude and frequency can result in selective and independent heating of magnetic nanoparticle ensembles. The differing magnetic coercivity of these particles, empirically characterized by a custom high amplitude alternating current magnetometer, informs the systematic selection of a multiplexed material system. This work culminates in a demonstration of magnetothermal multiplexing for selective remote control of cellular signaling in vitro.

show abstract

“…So far, one important limitation of these devices is the maximum available AC field strength. Although some instruments have been shown to generate high field intensities at frequencies up to 50 kHz [20,33], these frequencies are lower than those that are typically used for hyperthermia treatments. In the literature, the AC magnetometers that work in magnetic hyperthermia frequencies (100 kHz -1MHz), generate magnetic fields always smaller than 45 mT [17,21,31,34,35].…”

Section: Introductionmentioning

confidence: 97%

Exploring the potential of the dynamic hysteresis loops via high field, high frequency and temperature adjustable AC magnetometer for magnetic hyperthermia characterization

Rodrigo

Castellanos-Rubio

Garaio

et al. 2020

International Journal of Hyperthermia

View full text Add to dashboard Cite

Aim: The Specific Absorption Rate (SAR) is the key parameter to optimize the effectiveness of magnetic nanoparticles in magnetic hyperthermia. AC magnetometry arises as a powerful technique to quantify the SAR by computing the hysteresis loops' area. However, currently available devices produce quite limited magnetic field intensities, below 45mT, which are often insufficient to obtain major hysteresis loops and so a more complete and understandable magneticcharacterization. This limitation leads to a lack of information concerning some basic properties, like the maximum attainable (SAR) as a function of particles' size and excitation frequencies, or the role of the mechanical rotation in liquid samples. Methods: To fill this gap, we have developed a versatile high field AC magnetometer, capable of working at a wide range of magnetic hyperthermia frequencies (100 kHz-1MHz) and up to field intensities of 90mT. Additionally, our device incorporates a variable temperature system for continuous measurements between 220 and 380 K. We have optimized the geometrical properties of the induction coil that maximize the generated magnetic field intensity. Results: To illustrate the potency of our device, we present and model a series of measurements performed in liquid and frozen solutions of magnetic particles with sizes ranging from 16 to 29 nm. Conclusion: We show that AC magnetometry becomes a very reliable technique to determine the effective anisotropy constant of single domains, to study the impact of the mechanical orientation in the SAR and to choose the optimal excitation parameters to maximize heating production under human safety limits.

show abstract

High-Frequency and High-Field Hysteresis Loop Tracer for Magnetic Nanoparticle Characterization

Cited by 8 publications

References 16 publications

Magnetic Nanoparticle Systems for Nanomedicine—A Materials Science Perspective

Magnetic Nanoparticle Systems for Nanomedicine—A Materials Science Perspective

Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling

Exploring the potential of the dynamic hysteresis loops via high field, high frequency and temperature adjustable AC magnetometer for magnetic hyperthermia characterization

Contact Info

Product

Resources

About