High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients

Harwood, Catherine A.; McGregor, Jane; Swale, V. J.; Proby, Charlotte M.; Leigh, Irene M.; Newton, Robert; Khorshid, S. M.; Cerio, R.

doi:10.1067/mjd.2003.97

Cited by 78 publications

(82 citation statements)

References 22 publications

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“…This ratio differs from the one in the general population, in which BCC is more prevalent than SCC (ratio SCC to BCC = 1:4) [1]. Men are at a higher risk for SCC [3,4]. UV-light-exposed body regions are the predilection sites for SCC, its precursors actinic/solar keratosis (AK) and SCC in situ.…”

Section: Epithelial Skin Neoplasmsmentioning

confidence: 90%

“…Expression of cytokeratins (especially CK 5/6), p63 and CAM5.2 is particularly helpful for proving the epithelial origin of spindle cell SCC. Perineural growth appears not to be more frequent in OTR, but it indicates more extensive growth and a higher risk of recurrence [4,8,9]. The peritumoral inflammatory infiltrate is significantly less intense in OTR [4].…”

Section: Epithelial Skin Neoplasmsmentioning

confidence: 99%

“…Differentiation (grading) of SCC in OTR does not differ from SCC in the general population [4]. SCC in OTR presents more often with spindle cell morphology found in 20% of the lesions, and acantholysis [4,7]. Expression of cytokeratins (especially CK 5/6), p63 and CAM5.2 is particularly helpful for proving the epithelial origin of spindle cell SCC.…”

Section: Epithelial Skin Neoplasmsmentioning

confidence: 99%

“…The neoplastic cells show squamous differentiation with variable degrees of keratinization, mitoses and prominent nuclear pleomorphism, particularly at the invasion front and in poorly differentiated SCC. Differentiation (grading) of SCC in OTR does not differ from SCC in the general population [4]. SCC in OTR presents more often with spindle cell morphology found in 20% of the lesions, and acantholysis [4,7].…”

Section: Epithelial Skin Neoplasmsmentioning

confidence: 99%

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Skin Cancer in Organ Transplant Recipients

Kempf¹,

Mertz²,

Hofbauer

et al. 2013

Pathobiology

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Organ transplant recipients (OTR) are at a significantly increased risk for developing a wide variety of skin cancers, particularly epithelial skin cancer, Merkel cell carcinoma and Kaposi's sarcoma. Melanoma, skin adnexal neoplasm and cutaneous lymphomas are also more common in OTR and may differ in their clinicopathologic presentation from tumors in immunocompetent patients. The accuracy of clinical diagnosis of suspected premalignant and malignant skin lesions in OTR is modest. Therefore, histopathological diagnosis is an essential element for the diagnostic workup of skin cancers and, in addition, provides important information on prognosis. Squamous cell carcinoma and intraepithelial neoplasias (actinic keratosis, squamous cell carcinoma in situ or Bowen's disease) are the most common forms of skin cancer in OTR. The risk of Merkel cell carcinoma and Kaposi's sarcoma is dramatically increased in OTR. Merkel cell carcinoma shows a highly aggressive course. Kaposi's sarcoma tends to spread to extracutaneous sites. Primary cutaneous lymphomas developing after organ transplantation are rare. The spectrum of cutaneous B cell lymphomas in OTR, in particular, differs significantly from that of the general population, with a predominance of Epstein-Barr virus-driven posttransplant lymphoproliferative disorder. This review discusses the clinical and histopathological aspects of skin cancers in OTR, the impact of dermatopathological analysis on prognosis and the understanding of the pathogenesis of these neoplasms.

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Section: Epithelial Skin Neoplasmsmentioning

confidence: 90%

Section: Epithelial Skin Neoplasmsmentioning

confidence: 99%

Section: Epithelial Skin Neoplasmsmentioning

confidence: 99%

Section: Epithelial Skin Neoplasmsmentioning

confidence: 99%

See 2 more Smart Citations

Skin Cancer in Organ Transplant Recipients

Kempf¹,

Mertz²,

Hofbauer

et al. 2013

Pathobiology

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“…2 Healthy skin area from MCC patients. 3 Nontruncated MCPyV LT-ag. 4 Samples obtained from the current study.…”

Section: Resultsmentioning

confidence: 99%

Genetic and Structural Analysis of Merkel Cell Polyomavirus Large T Antigen from Diverse Biological Samples

Baez

Dı́az²,

Cavalcanti³

et al. 2014

Intervirology

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Merkel cell polyomavirus (MCPyV) large T antigen (LT-ag) is frequently found truncated in Merkel cell carcinomas (MCC) and it is considered a major tumor-specific signature. Nonetheless, the biological role of LT-ag nontruncated mutations is largely unknown. In this study, MCPyV LT-ag second exon from 11 non-MCC oral samples and NCBI sequences derived from different anatomical sites were studied from the genetic and structural standpoint. As expected, the LT-ag mutation profile was influenced by the geographical origin of the sample, although nonsynonymous mutations were more frequent in lesional tissues. Our in silico study suggests that the mutations found would not significantly affect protein functions, regardless of sample category. This work presents a thorough investigation of the structural and functional properties of LT-ag nontruncated mutations in MCPyV. Our results sustain the geographical influence of the MCPyV genetic profile, but do not discard genetic tissue specificities. Further investigation involving other genetic segments in healthy and lesional tissues are necessary to improve our knowledge on MCPyV pathogenesis.

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Tumor Mapping in 2 Large Multigenerational Families With CYLD Mutations

Rajan¹,

Langtry²,

Ashworth³

et al. 2009

Arch Dermatol

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Objective To comprehensively ascertain the extent and severity of clinical features in multiple affected individuals from two large families with proven heterozygous mutations in the CYLD locus and to correlate these findings with the three appendageal tumor predisposition syndromes, familial cylindromatosis (FC), Brooke-Spiegler syndrome (BSS), and multiple familial trichoepitheliomas (MFT) known to be associated with such germline mutations. Design Inter- and intra-familial observational study. Setting Tertiary genetic and dermatology referral centre. Participants 32 individuals were recruited from two large multigenerational families with CYLD mutations. Clinical details, history and tumor maps were obtained from all participants whilst 18 were further corroborated with detailed clinical examination. Main outcome measures Severity of tumor density, distribution and histology, associated medical conditions, patient symptoms and impact of disease on quality of life. Results We demonstrate a wide variation in clinical presentation seen in individuals from the same family. In addition, we provide clinical evidence that correlates with hormonally stimulated hair follicles being particularly vulnerable to loss of heterozygosity and tumor induction. Conclusion In view of our findings, we propose that the burden of disease at sites other than the head and neck is underreported in the literature, but impacts greatly on quality of life. The differentiation between the clinical diagnoses has little prognostic or clinical utility in genetic counselling even within individuals from the same family. Thus, we suggest an encompassing diagnosis of “CYLD cutaneous syndrome”. Finally, our results relating to the clinical distribution of tumors suggest hormonal factors may play an important role in tumor induction in these patients.

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High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients

Cited by 78 publications

References 22 publications

Skin Cancer in Organ Transplant Recipients

Skin Cancer in Organ Transplant Recipients

Genetic and Structural Analysis of Merkel Cell Polyomavirus Large T Antigen from Diverse Biological Samples

Tumor Mapping in 2 Large Multigenerational Families With CYLD Mutations

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