High-Frequency Acoustic Droplet Vaporization is Initiated by Resonance

Lajoinie, Guillaume; Segers, Tim; Versluis, Michel

doi:10.1103/physrevlett.126.034501

Cited by 14 publications

(6 citation statements)

References 46 publications

(54 reference statements)

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“…The quarter period of MHz waves is several orders of magnitude longer than the time necessary for an ion to nucleate a critical embryo, which was estimated to be in the order of tens of picoseconds [7]. This low frequency also ensures a relatively uniform pressure distribution within the droplet, whereas higher frequencies would lead to unwanted effects such as droplet resonance [43] or acoustic focusing [44]. A custom-made high-intensity focused transducer was used (center frequency 1.1 MHz), built from a spherically-focused PZT element (48 mm, Meggit Ferroperm, Coventry, UK) and air-backed to ensure a high transmission efficiency.…”

Section: B Acoustic Modulation Transducermentioning

confidence: 99%

Acoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature

Heymans

Collado-Lara

Rovituso³

et al. 2022

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Superheated nanodroplet vaporization by proton radiation was recently demonstrated, opening the door to ultrasound-based in vivo proton range verification. However, at body temperature and physiological pressures, perfluorobutane nanodroplets (PFB-NDs), which offer a good compromise between stability and radiation sensitivity, are not directly sensitive to primary protons. Instead, they are vaporized by infrequent secondary particles, which limits the precision for range verification. The radiation-induced vaporization threshold (i.e. sensitization threshold) can be reduced by lowering the pressure in the droplet such that nanodroplet vaporization by primary protons can occur. Here, we propose to use an acoustic field to modulate the pressure, intermittently lowering the proton sensitization threshold of PFB-NDs during the rarefactional phase of the ultrasound wave. Simultaneous proton irradiation and sonication with a 1.1 MHz focused transducer, using increasing peak negative pressures (PNPs), were applied on a dilution of PFB-NDs flowing in a tube, while vaporization was acoustically monitored with a linear array. Sensitization to primary protons was achieved at temperatures between 29 and 40°C using acoustic PNPs of relatively low amplitude (from 800 kPa to 200 kPa, respectively), while sonication alone did not lead to ND vaporization at those PNPs. Sensitization was also measured at the clinically relevant body temperature (i.e., 37°C) using a PNP of 400 kPa. These findings confirm that acoustic modulation lowers the sensitization threshold of superheated nanodroplets, enabling a direct proton response at body temperature.

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Section: B Acoustic Modulation Transducermentioning

confidence: 99%

Acoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature

Heymans

Collado-Lara

Rovituso³

et al. 2022

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…Usually, the resonant frequency f * is selected as the high frequency f 2 to induce the cavitation of nanodroplets according to the equation f * ∙R ∼ 0.65. [ 18 ] The size of the nanodroplets is controlled to be 379.4 ± 35 nm, thus the resonant ultrasound frequency of 1 MHz can be used as the high frequency f 2 to cause the cavitation of the nanodroplets which have already diffused into the thrombus under the ultrasound with the low frequency f 1 . Under the ultrasound with the high frequency f 2 , the cavitation will generate shock waves or micro jets.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, the cavitation of droplets has been realized by adjusting ultrasonic parameters, such as acoustic pressure and acoustic frequency. [ 18 ] For the cavitation of droplets, the resonant frequency is relevant to the size. In addition, the diffusion of droplets needs to be taken account simultaneously in this study, which is also relevant to the size.…”

Section: Discussionmentioning

confidence: 99%

Dual‐Frequency Ultrasound Assisted Thrombolysis in Interventional Therapy of Deep Vein Thrombosis

Pan,

Li,

Chen

et al. 2023

Adv Healthcare Materials

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Deep vein thrombosis (DVT) is one of the main causes of disability and death worldwide. Currently, the treatment of DVT still needs a long time and faces a high risk of major bleeding. It is necessary to find a rapid and safe method for the therapy of DVT. Here, a dual‐frequency ultrasound assisted thrombolysis (DF‐UAT) is reported for the interventional treatment of DVT. A series of piezoelectric elements are placed in an interventional catheter to emit ultrasound waves with two independent frequencies in turn. The low‐frequency ultrasound drives the drug‐loaded droplets into the thrombus, while the high‐frequency ultrasound causes the cavitation of the droplets in the thrombus. With the joint effect of the enhanced drug diffusion and the cavitation under the dual‐frequency ultrasound, the thrombolytic efficacy can be improved. In a proof‐of‐concept experiment performed with living sheep, the recanalization of the iliac vein is realized in 15 min using the DF‐UAT technology. Therefore, the DF‐UAT can be one of the most promising methods in the interventional treatment of DVT.

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“…Second, the input frequency should match the resonance frequency of the whole system ( 46 , 47 ), including the external system described above and the fluid inside the microchannel. This resonance frequency can be obtained by calculating the eigenmodes of the system (fig.…”

Section: Resultsmentioning

confidence: 99%

A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER)

et al. 2022

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High-precision isolation of small extracellular vesicles (sEVs) from biofluids is essential toward developing next-generation liquid biopsies and regenerative therapies. However, current methods of sEV separation require specialized equipment and time-consuming protocols and have difficulties producing highly pure subpopulations of sEVs. Here, we present Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER), which allows single-step, rapid (<10 min), high-purity (>96% small exosomes, >80% exomeres) fractionation of sEV subpopulations from biofluids without the need for any sample preprocessing. Particles are iteratively deflected in a size-selective manner via an excitation resonance. This previously unidentified phenomenon generates patterns of virtual, tunable, pillar-like acoustic field in a fluid using surface acoustic waves. Highly precise sEV fractionation without the need for sample preprocessing or complex nanofabrication methods has been demonstrated using ANSWER, showing potential as a powerful tool that will enable more in-depth studies into the complexity, heterogeneity, and functionality of sEV subpopulations.

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High-Frequency Acoustic Droplet Vaporization is Initiated by Resonance

Cited by 14 publications

References 46 publications

Acoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature

Acoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature

Dual‐Frequency Ultrasound Assisted Thrombolysis in Interventional Therapy of Deep Vein Thrombosis

A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER)

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