High Frequency (10 kHz) or Burst Spinal Cord Stimulation in Failed Back Surgery Syndrome Patients With Predominant Back Pain: Preliminary Data From a Prospective Observational Study

Kinfe, Thomas M.; Pintea, Bogdan; Link, Carolina; Roeske, Sandra; Güresir, Erdem; Güresir, Ági; Vatter, Hartmut

doi:10.1111/ner.12379

Cited by 62 publications

(55 citation statements)

References 42 publications

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“…Furthermore, we found a correlation between IL‐10 changes and Burst SCS responsiveness for back pain and sleep quality. The observations made in this study were in line with those of the previous published data related to Burst SCS outcome in back pain .…”

Section: Discussionsupporting

confidence: 92%

Burst Spinal Cord Stimulation Increases Peripheral Antineuroinflammatory Interleukin 10 Levels in Failed Back Surgery Syndrome Patients With Predominant Back Pain

Kinfe

Muhammad

Link

et al. 2017

Neuromodulation: Technology at the Neural Interface

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Section: Discussionsupporting

confidence: 92%

Burst Spinal Cord Stimulation Increases Peripheral Antineuroinflammatory Interleukin 10 Levels in Failed Back Surgery Syndrome Patients With Predominant Back Pain

Kinfe

Muhammad

Link

et al. 2017

Neuromodulation: Technology at the Neural Interface

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“…The emergence of kilohertz frequency (1–10 KHz ) spinal cord stimulation (kHz-SCS) 1–7 for the treatment of neuropathic pain has engendered studies on new mechanisms of actions (MoA) 5,8–11 . Divergent clinical observations for conventional rate SCS and kHZ-SCS suggest difference in MoA which could in turn inform distinct programming optimization strategies.…”

Section: Introductionmentioning

confidence: 99%

Temperature increases by kilohertz frequency spinal cord stimulation

et al. 2019

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Introduction: Kilohertz frequency spinal cord stimulation (kHz-SCS) deposits significantly more power in tissue compared to SCS at conventional frequencies, reflecting increased duty cycle (pulse compression). We hypothesize kHz-SCS increases local tissue temperature by joule heat, which may influence the clinical outcomes. Methods: To establish the role of tissue heating in KHZ-SCS, a decisive first step is to characterize the range of temperature changes expected during conventional and KHZ-SCS protocols. Fiber optic probes quantified temperature increases around an experimental SCS lead in a bath phantom. These data were used to verify a SCS lead heat-transfer model based on joule heat. Temperature increases were then predicted in a seven-compartment (soft tissue, vertebral bone, fat, intervertebral disc, meninges, spinal cord with nerve roots) geometric human spinal cord model under varied parameterization. Results: The experimentally constrained bio-heat model shows SCS waveform power (waveform RMS) determines tissue heating at the spinal cord and surrounding tissues. For example, we predict temperature increased at dorsal spinal cord of 0.18–1.72 °C during 3.5 mA peak 10 KHz stimulation with a 40–10–40 μs biphasic pulse pattern, 0.09–0.22 °C during 3.5 mA 1 KHz 100–100–100 μs stimulation, and less than 0.05 °C during 3.5 mA 50 Hz 200–100–200 μs stimulation. Notably, peak heating of the spinal cord and other tissues increases superlinearly with stimulation power and so are especially sensitive to incremental changes in SCS pulse amplitude or frequency (with associated pulse compression). Further supporting distinct SCS intervention strategies based on heating; the spatial profile of temperature changes is more uniform compared to electric fields, which suggests less sensitivity to lead position. Conclusions: Tissue heating may impact short and long-term outcomes of KHZ-SCS, and even as an adjunct mechanism, suggests distinct strategies for lead position and programming optimization.

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“…HF10-SCS and burst SCS were both safe and efficacious for treating intractable pain in these patients, and provided significant reduction in VAS and improvement in sleep quality as measured by the Pittsburgh Sleep Quality Index [69]. Russo et al [70, 71] also found favorable results in a retrospective review of 256 patients who trialed HF10-SCS for chronic intractable pain of various etiologies; they reported notable improvements in both pain and ODI scores.…”

Section: Review Of Clinical Datamentioning

confidence: 99%

Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy

Chakravarthy

Richter

Christo

et al. 2018

Neuromodulation: Technology at the Neural Interface

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To fully understand and utilize paresthesia-free HF-SCS, mechanistic study and translational research will be very important, with increasing collaboration between basic science and clinical communities to design better trials and optimize the therapy based on mechanistic findings from effective preclinical models and approaches. Future research in these vital areas may include preclinical and clinical components conducted in parallel to optimize the potential of this technology.

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High Frequency (10 kHz) or Burst Spinal Cord Stimulation in Failed Back Surgery Syndrome Patients With Predominant Back Pain: Preliminary Data From a Prospective Observational Study

Cited by 62 publications

References 42 publications

Burst Spinal Cord Stimulation Increases Peripheral Antineuroinflammatory Interleukin 10 Levels in Failed Back Surgery Syndrome Patients With Predominant Back Pain

Burst Spinal Cord Stimulation Increases Peripheral Antineuroinflammatory Interleukin 10 Levels in Failed Back Surgery Syndrome Patients With Predominant Back Pain

Temperature increases by kilohertz frequency spinal cord stimulation

Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy

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