High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis

Yamaguchi, Hayato; Kabashima-Kubo, Rieko; Bito, Toshinori; Sakabe, Jun‐ichi; Shimauchi, Takatoshi; Ito, Taisuke; Hirakawa, Satoshi; Hirasawa, Noriyasu; Ogasawara, Kunio; Tokura, Y.

doi:10.1016/j.jdermsci.2013.07.009

Cited by 33 publications

(34 citation statements)

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“…2 Genotyping was performed using polymerase chain reaction and restriction enzyme digest analysis, which was approved by our ethics committee. 3 We identified S2889X FLG gene heterozygous nonsense mutation in this patient.…”

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confidence: 72%

“…3 Histological characteristics of perifollicular elastolysis include a lack of elastic fibers around perifollicular and sebaceous units. The differential diagnosis of perifollicular elastolysis includes post-acne scars, varicella, white fibrous papulosis of the neck (WFPN), pseudoxanthoma elasticum-like papillary dermal elastolysis, milium and atrophoderma vermiculatum.…”

Section: Perifollicular Elastolysis With Atopic Dermatitismentioning

confidence: 99%

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Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation

Nakazawa

Moriki

Ikeya

et al. 2013

The Journal of Dermatology

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Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation Dear Editor, Poikiloderma is a characteristic skin condition consisting of pigmentation, depigmentation, telangiectasia and atrophy, and is seen in a number of diseases. Here, we report a patient with atopic dermatitis (AD) with filaggrin (FLG) gene mutation, presenting as marked generalized poikiloderma.A 26-year-old man was referred to us for evaluation of his recalcitrant itchy eruption. In his childhood, the patient had asthma and eczematous lesions, diagnosed as AD, which gradually turned to poikiloderma in his late teens. His AD had been treated with topical corticosteroids, but he denied their extensive usage. On examination, the patient had a poikilodermatous eruption on the chest (Fig. 1a) and back (Fig. 1b), extending to the neck and proximal parts of the limbs. The eruption was a mixture of small pigmentary and depigmentary elements with fine telangiectasia (Fig. 1c). Concomitantly, there were eczematous lesions on the antecubital fossae and dorsal aspects of the hands. He had palmar hyperlinearity (Fig. 1d) and scaly dry skin on the extremities, especially on the shins.

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confidence: 72%

Section: Perifollicular Elastolysis With Atopic Dermatitismentioning

confidence: 99%

Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation

Nakazawa

Moriki

Ikeya

et al. 2013

The Journal of Dermatology

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“…Obserwację tę można wytłumaczyć faktem, że Dermatology Review/Przegląd Dermatologiczny 2017/2 teristic for ACD, and eAD patients Th2-dependent cytokine overproduction associated with atopic diseases. What is more, sweat of iAD patients revealed a higher nickel concentration than in the samples of eAD patients [45]. This may suggest that nickel excreted with the sweat may exacerbate skin lesions in iAD.…”

Section: Atopowe Zapalenie Skórymentioning

confidence: 84%

“…Local inflammation, administration of glucocorticoids and epithelial barrier disorders may affect the immunological state of the skin, which pacjenci z iAD charakteryzują się profilem cytokin zależnych od Th1 charakterystycznym dla wyprysku kontaktowego, a pacjenci z eAD -profilem zależ-nym od Th2, typowym dla atopii. Ponadto u pacjentów z iAD stwierdzono wyższe stężenie niklu w pocie w porównaniu z pacjentami z eAD [45]. Może to sugerować, że wydzielany z potem nikiel powoduje nasilenie zmian skórnych u chorych z iAD.…”

Section: Discussionunclassified

Contact hypersensitivity to nickel in patients with atopic dermatitis

Rożalski¹,

Blicharz²,

Samochocki³

2017

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Atopic dermatitis is a chronic, recurrent inflammatory dermatosis with a complex and not fully explained pathogenesis. Recent years' research points to a significant percentage of patients with atopic eczema in whom hapten patch test results are positive, especially with respect to nickel. These observations undermine suggestions that contact allergy (type IV hypersensitivity) is rare in this group due to the dominance of the Th2-type cellular response characteristic for type I allergic reactions. In this review we aimed to systematize current knowledge regarding the pathomechanisms of contact hypersensitivity to nickel in patients with atopic dermatitis and the potential influence of this hapten on the clinical course of the disease. STRESZCZENIEAtopowe zapalenie skóry jest przewlekłą, nawrotową dermatozą zapalną o złożonej, nie w pełni wyjaśnionej etiopatogenezie. Badania z ostatnich lat wskazują na istotny odsetek chorych na wyprysk atopowy, u których stwierdza się dodatnie wyniki płatkowych testów kontaktowych z haptenami, głównie z niklem. Obserwacje te przeczą sugestii, że w tej grupie pacjentów alergia kontaktowa (IV mechanizm nadwrażliwości) jest rzadkim zjawiskiem ze względu na przewagę odpowiedzi komórkowej typu Th2, typowej dla I mechanizmu nadwraż-liwości. W poniższej pracy autorzy podjęli próbę usystematyzowania dotychczasowej wiedzy o patomechanizmie rozwoju nadwrażliwości kontaktowej na nikiel u chorych na atopowe zapalenie skóry i ewentualnym wpływie tego haptenu na kliniczny przebieg schorzenia.

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“…The skin barrier is perturbed in the extrinsic, but not intrinsic type [1], and thus filaggrin gene mutations are not a feature of intrinsic AD [2]. We have shown that metal allergy may induce such an immunological state in intrinsic AD [1,4]. We have shown that metal allergy may induce such an immunological state in intrinsic AD [1,4].…”

Section: Psychological Aspects Of Patients With Intrinsic Atopic Dermmentioning

confidence: 86%

Psychological aspects of patients with intrinsic atopic dermatitis

Yamaguchi

Hata

Fujiyama

et al. 2014

European Journal of Dermatology

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253 1. Hara M, Watanabe M, Tagami H. Jacquet erosive diaper dermatitis in a young girl with urinary incontinence. Pediatr Dermatol 1991; 8: 160-1. 2. Virgili A, Corazza M, Califano A. Diaper dermatitis in an adult. A case of erythema papuloerosive of Sevestre and Jacquet. J Reprod Med 1998; 43: 949-51. 3. Van L, Harting M, Rosen T. Jacquet erosive diaper dermatitis: a complication of adult urinary incontinence. Cutis 2008; 82: 72-4. 4. Rodriguez-Poblador J, González-Castro U, Herranz-Martínez S, Luelmo-Aguilar J. Jacquet erosive diaper dermatitis after surgery for Hirschsprung disease. Pediatr Dermatol 1998; 15: 46-7. 5. Robson KJ, Maughan JA, Purcell SD, Petersen MJ, Haefner HK, Lowe L. Erosive papulonodular dermatosis associated with topical benzocaine: a report of two cases and evidence that granuloma gluteale, pseudoverrucous papules, and Jacquet's erosive dermatitis are a disease spectrum. J Am Acad Dermatol 2006; 55: S74-80. 6. Buckingham KW, Berg RW. Etiologic factors in diaper dermatitis: the role of feces. Pediatr Dermatol 1986; 3: 107-12. 7. Berg RW, Buckingham KW, Stewart RL. Etiologic factors in diaper dermatitis: the role of urine. Pediatr Dermatol 1986; 3: 102-6. 8. Maruani A, Lorette G, Barbarot S, et al. Re-emergence of papulonodular napkin dermatitis with use of reusable diapers: report of 5 cases. Eur J Dermatol 2013; 23: 246-9. 9. Markham T, Kennedy F, Collins P. Topical sucralfate for erosive irritant diaper dermatitis.

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High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis

Cited by 33 publications

References 55 publications

Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation

Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation

Contact hypersensitivity to nickel in patients with atopic dermatitis

Psychological aspects of patients with intrinsic atopic dermatitis

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