High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in                    the Abdominal Aorta: First Human Results

Engelhard, Stefan; Voorneveld, Jason; Vos, Hendrik J.; Westenberg, Jos J.M.; Gijsen, Frank; Taimr, Pavel; Versluis, Michel; Jong, Nico de; Bosch, Johan G.; Reijnen, Michel M.P.J.; Jebbink, Erik Groot

doi:10.1148/radiol.2018172979

Cited by 24 publications

(36 citation statements)

References 14 publications

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“…High frame rate contrast enhanced ultrasonography was successfully performed in the abdominal aorta of healthy volunteers. Velocity field information could be determined using ePIV (with the optimization described in this study) which was very similar to 4D phase-contrast magnetic resonance imaging [23]. of 0.01 (a, b) and 0.06 (c, d)…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the volunteers underwent MRI phase contrast imaging and the detected flow was compared to the ePIV results. This part of the study is not further described here, but reported elsewhere [23].…”

Section: A Study Designmentioning

confidence: 99%

“…Tissue suppression efficacy was assessed using contrast-to-background ratio (CBR) [23], defined as = 10 log 10 � ��…”

Section: E Contrast-to-background Ratio (Cbr)mentioning

confidence: 99%

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High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Voorneveld

Engelhard

Vos

et al. 2018

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Treatment of abdominal aortic (AA) aneurysms and stenotic lesions may be improved by analyzing their associated blood flow patterns. Angle-independent blood flow patterns in the AA can be obtained by combining echo-particle image velocimetry (ePIV) with high frame rate contrast-enhanced ultrasonography. However, ePIV performance is affected by ultrasound contrast agent (UCA) concentration, microbubble stability and tissue clutter. In this study we assessed the influence of acoustic pressure and UCA concentration on image quality for ePIV analysis. We also compared amplitude modulation (AM) and singular value decomposition (SVD) as tissue suppression strategies for ePIV. Fourteen healthy volunteers were imaged in the region of the distal AA. We tested four different UCA bolus volumes (0.25, 0.5, 0.75 and 1.5 ml) and four different acoustic output pressures (mechanical indices: 0.01, 0.03, 0.06 and 0.09). As image quality metrics, we measured contrast-to-background ratio, bubble disruption ratio and maximum normalized cross-correlation value during ePIV. At mechanical indices ≥ 0.06, we detected severe bubble destruction, suggesting that very low acoustic pressures should be used for ePIV. SVD was able to suppress tissue clutter better than AM. The maximum tracking correlation was affected by both UCA concentration and flow rate, where at high flow rates, lower UCA concentrations resulted in slightly higher correlation values but more signal drop-outs during late diastole. High frame rate ePIV was successfully performed in the AA of healthy volunteers and shows promise for future studies in patients.

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Section: Discussionmentioning

confidence: 99%

Section: A Study Designmentioning

confidence: 99%

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High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Voorneveld

Engelhard

Vos

et al. 2018

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…A novel medical-based flow study technique is ultrasound PIV. In vitro studies 8,9 , as well as first clinical studies 10,11 , show the wide applicability of this technique. Also, in vitro validation of ultrasound PIV in the presence of a stent was recently performed 12 .…”

Section: Introductionmentioning

confidence: 91%

Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model

Mikhal

Hoving

Ong

et al. 2019

Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling

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Introduction. Treatment choice for extracranial carotid artery widening, also called aneurysm, is difficult. Blood flow simulation and experimental visualization can be supportive in clinical decision making and patient-specific treatment prediction. This study aims to simulate and validate the effect of flow-diverting stent placement on blood flow characteristics using numerical and in vitro simulation techniques in simplified carotid artery and aneurysm models.Methods. We have developed a workflow from geometry design to flow simulations and in vitro measurements in a carotid aneurysm model. To show feasibility of the numerical simulation part of the workflow that uses an immersed boundary method, we study a model geometry of an extracranial carotid artery aneurysm and put a flow-diverting stent in the aneurysm. We use ultrasound particle image velocimetry (PIV) to visualize experimentally the flow inside the aneurysm model.Results. Feasibility of ultrasound visualization of the flow, virtual flow-diverting stent placement and numerical flow simulation are presented. Flow is resolved to scales much smaller than the cross section of individual wires of the flowdiverting stent. Numerical analysis in stented model introduced 25% reduction of the blood flow inside the aneurysm sac. Quantitative comparison of experimental and numerical results showed agreement in 1D velocity profiles.Discussion/conclusion. We find good numerical convergence of the simulations at appropriate spatial resolutions using the immersed boundary method. This allows us to quantify the changes in the flow in model geometries after deploying a flow-diverting stent. We visualized the physiological blood flow in a 1-to-1 aneurysm model, using PIV, showing a good correspondence to the numerical simulations. The novel workflow enables numerical as well as experimental flow simulations in patient-specific cases before and after flow-diverting stent placement. This may contribute to endovascular treatment prediction.

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“…55,61 Furthermore, ventricular filling is studied using four-dimensional flow MRI. 16 Ultrasound-based vector flow imaging and echoPIV are used to study flow in the ascending aorta, 22 the abdominal aorta, 17,63 and to study ventricular blood flow. 27,32 The latter is also reported in combination with optical PIV flow studies.…”

Section: Strengths and Limitations Of This Reviewmentioning

confidence: 99%

A Systematic Review for the Design of In Vitro Flow Studies of the Carotid Artery Bifurcation

Hoving

Vries

Mikhal

et al. 2019

Cardiovasc Eng Tech

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Associate Editor Patrick Segers oversaw the review of this article. AbstractPurpose-In vitro blood flow studies in carotid artery bifurcation models may contribute to understanding the influence of hemodynamics on carotid artery disease. However, the design of in vitro blood flow studies involves many steps and selection of imaging techniques, model materials, model design, and flow visualization parameters. Therefore, an overview of the possibilities and guidance for the design process is beneficial for researchers with less experience in flow studies. Methods-A systematic search to in vitro flow studies in carotid artery bifurcation models aiming at quantification and detailed flow visualization of blood flow dynamics results in inclusion of 42 articles. Results-Four categories of imaging techniques are distinguished: MRI, optical particle image velocimetry (PIV), ultrasound and miscellaneous techniques. Parameters for flow visualization are categorized into velocity, flow, shearrelated, turbulent/disordered flow and other parameters. Model materials and design characteristics vary between study type. Conclusions-A simplified three-step design process is proposed for better fitting and adequate match with the pertinent research question at hand and as guidance for less experienced flow study researchers. The three consecutive selection steps are: flow parameters, image modality, and model materials and designs. Model materials depend on the chosen imaging technique, whereas choice of flow parameters is independent from imaging technique and is therefore only determined by the goal of the study. Comparative study of magnetic resonance imaging and image-based computational fluid dynamics for quantification of pulsatile flow in a carotid bifurcation phantom. Ann. Biomed. Eng. 31(8):962-971, 2003.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.BIOMEDICAL ENGINEERING SOCIETY

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High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results

Cited by 24 publications

References 14 publications

High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

High-Frame-Rate Contrast-Enhanced Ultrasound for Velocimetry in the Human Abdominal Aorta

Fully resolved simulation and ultrasound flow studies in stented carotid aneurysm model

A Systematic Review for the Design of In Vitro Flow Studies of the Carotid Artery Bifurcation

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