High‐fluence 1064‐nm Q‐Switched Nd:YAG laser: Safe and effective treatment of café‐au‐lait macules in Asian patients

Abstract

A high-fluence 1064-nm Q-switched Nd:YAG laser treatment of CALMs in Asian patients is a safe and effective method without side effects and recurrence.

Preliminary experience of the Q‐switched 1064‐nm neodymium:yttrium aluminum garnet laser in the treatment of Café‐au‐lait macules

“…[2][3][4][5][6][7] Based on the theory of selective photothermolysis, the Q-switched lasers were most accepted modality to remove CALMs with higher efficacy and minimal adverse effects. 8,9 We have introduced a powerful treatment of CALMs using a QS 1064 nm Nd: yttrium aluminum garnet (YAG) laser to avoid both the sideeffects and recurrence in Chinese patients. Data were collected from the records of CAML patients who received only QS 1064nm Nd:YAG laser.…”

The Treatment of Infantile Cafe Au Lait Spot Using Dr. Hoon Hur’s Golden Parameter Therapy with a High Fluence 1064nm Q-Switched Nd: Yag Laser

“…Finally, the reactive oxygen species such as free radical oxygen and peroxide or nitric oxide generated by damaged keratinocytes activate melanocytes and strengthen melanin synthesis in melanosomes, eventually leading to PIH and exacerbating CALS [8][9][10]. The authors devised a new treatment using a Dr.Hoon Hur's GPT with a high fluence1064nm QSNL (StarWalkerLaser, Fotona, Slovenia).The parameters were a spot size of 7 mm, a fluence of 2.2 J/cm 2 and a pulse rate of 10Hz with one pass by a sliding-stacking technique over the infantile CALS at intervals of one week.We believe that Dr. Hoon Hur's GPT using a high fluence 1064 nm QSNL is safer and more effective than the traditional CALS treatments [12][13][14][15]. In previous papers, the authors also reported that Dr. Hoon Hur's GPT using a high 1064 nm QSNL is a very effective therapy without harmful side effects such as PIH, mottled hypopigmentation or scarring in various pigmentary skin diseases such as café au lait spot [12][13][14][15], partial unilateral lentiginosis [13,16], Becker's nevus [13], Ota's nevus [17], Hori's nevus [18], congenital melanocytic nevus [19], Riehl's melanosis [20], erythema ab igne [21] and prurigo pigmentosa [22].…”

“…The authors devised a new treatment using a Dr.Hoon Hur's GPT with a high fluence1064nm QSNL (StarWalkerLaser, Fotona, Slovenia).The parameters were a spot size of 7 mm, a fluence of 2.2 J/cm 2 and a pulse rate of 10Hz with one pass by a sliding-stacking technique over the infantile CALS at intervals of one week.We believe that Dr. Hoon Hur's GPT using a high fluence 1064 nm QSNL is safer and more effective than the traditional CALS treatments [12][13][14][15]. In previous papers, the authors also reported that Dr. Hoon Hur's GPT using a high 1064 nm QSNL is a very effective therapy without harmful side effects such as PIH, mottled hypopigmentation or scarring in various pigmentary skin diseases such as café au lait spot [12][13][14][15], partial unilateral lentiginosis [13,16], Becker's nevus [13], Ota's nevus [17], Hori's nevus [18], congenital melanocytic nevus [19], Riehl's melanosis [20], erythema ab igne [21] and prurigo pigmentosa [22]. We think that Dr. Hoon Hur's GPT, which is performed regularly on a weekly basis with minimal damage to the epidermis, promotes gradual destruction of melanocytes in the epidermis or dermis, leading to apoptotic melanocytic cell death program [12][13][14][15].Due to the poor absorption by epidermal melanin, Dr. Hoon Hur's GPT with the adoption of high fluence 1064-nm QSNL is able to destroy the melanosomes in the epidermal melanocytes with minimal epidermal damage, finally causing epidermal melanocytes to lose functions and turn into ghost cells [12][13][14][15].…”

“…In previous papers, the authors also reported that Dr. Hoon Hur's GPT using a high 1064 nm QSNL is a very effective therapy without harmful side effects such as PIH, mottled hypopigmentation or scarring in various pigmentary skin diseases such as café au lait spot [12][13][14][15], partial unilateral lentiginosis [13,16], Becker's nevus [13], Ota's nevus [17], Hori's nevus [18], congenital melanocytic nevus [19], Riehl's melanosis [20], erythema ab igne [21] and prurigo pigmentosa [22]. We think that Dr. Hoon Hur's GPT, which is performed regularly on a weekly basis with minimal damage to the epidermis, promotes gradual destruction of melanocytes in the epidermis or dermis, leading to apoptotic melanocytic cell death program [12][13][14][15].Due to the poor absorption by epidermal melanin, Dr. Hoon Hur's GPT with the adoption of high fluence 1064-nm QSNL is able to destroy the melanosomes in the epidermal melanocytes with minimal epidermal damage, finally causing epidermal melanocytes to lose functions and turn into ghost cells [12][13][14][15]. The more weekly Dr. Hoon Hur's GPT using a high fluence 1064 nm QSNL is performed, the more epidermal melanocytes are destroyed and the apoptosis of epidermal melanocytes is promoted.…”

“…The more weekly Dr. Hoon Hur's GPT using a high fluence 1064 nm QSNL is performed, the more epidermal melanocytes are destroyed and the apoptosis of epidermal melanocytes is promoted. Moreover, the dispersed melanosomes and melanins, the end product of destroyed melanocytes, are either eliminated by transepidermal elimination or by dermal melanophages through the lymphatic system [12][13][14][15]. The lesional melanocytes are gradually replaced by normal melanocytes, which migrate from the outer root sheath of hair follicles by apoptotic melanocytic cell death program and homeostasis.Finally, CALS can be completely removed without any side effects or recurrences [12][13][14][15].…”