“…For the complete analysis see online Supporting Information (Table S1 ). The included studies comprised eight gastrointestinal [ 8 , 9 , 12 , 22 , 34 , 35 , 36 , 37 ], five bronchoscopy [ 11 , 24 , 26 , 38 , 39 ], three cardiology [ 21 , 27 , Scheuermann‐Jahn et al., preprint, https://doi.org/10.21203/rs.3.rs‐989822/v1 ], two dental trials [ 23 , 40 ] and one endovascular trial [ 25 ]. Three of the trials studied children [ 21 , 23 , 26 ], one each in cardiology [ 21 ], bronchoscopy [ 26 ] and dental procedures [ 23 ] with a total sample size of 329 patients.…”