High flow nasal cannula versus conventional oxygen therapy and non-invasive ventilation in adults with acute hypoxemic respiratory failure: A systematic review

Lee, Chi Chan; Mankodi, Dhruti; Shaharyar, Sameer; Ravindranathan, Sharmila; Danckers, Mauricio; Herscovici, Pablo; Moor, Molly; Ferrer, Gustavo

doi:10.1016/j.rmed.2016.11.004

Cited by 100 publications

(110 citation statements)

References 35 publications

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“…In these conditions, the increased oxygen cost of breathing may contribute to increased energy cost during activities of daily living adding, particularly in diseases imposing a ventilator or cardiac constraint, an extra contribution to the reduced exercise capacity. Several interventions have been used in different patient populations to reduce WOB, which has a potential impact on reducing the oxygen cost of breathing, namely, invasive and noninvasive ventilation [248][249][250], high flow nasal oxygen [248,251], ventilation with heliox [252], respiratory muscle training [253,254] and exercise training [255].…”

Section: Oxygen Cost Of Breathingmentioning

confidence: 99%

ERS statement on respiratory muscle testing at rest and during exercise

et al. 2019

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Assessing respiratory mechanics and muscle function is critical for both clinical practice and research purposes. Several methodological developments over the past two decades have enhanced our understanding of respiratory muscle function and responses to interventions across the spectrum of health and disease. They are especially useful in diagnosing, phenotyping and assessing treatment efficacy in patients with respiratory symptoms and neuromuscular diseases. Considerable research has been undertaken over the past 17 years, since the publication of the previous American Thoracic Society (ATS)/European Respiratory Society (ERS) statement on respiratory muscle testing in 2002. Key advances have been made in the field of mechanics of breathing, respiratory muscle neurophysiology (electromyography, electroencephalography and transcranial magnetic stimulation) and on respiratory muscle imaging (ultrasound, optoelectronic plethysmography and structured light plethysmography). Accordingly, this ERS task force reviewed the field of respiratory muscle testing in health and disease, with particular reference to data obtained since the previous ATS/ERS statement. It summarises the most recent scientific and methodological developments regarding respiratory mechanics and respiratory muscle assessment by addressing the validity, precision, reproducibility, prognostic value and responsiveness to interventions of various methods. A particular emphasis is placed on assessment during exercise, which is a useful condition to stress the respiratory system.

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Section: Oxygen Cost Of Breathingmentioning

confidence: 99%

ERS statement on respiratory muscle testing at rest and during exercise

et al. 2019

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“…Dennoch konnte in der Studie eindrucksvoll gezeigt werden, dass unter High-Flow-Sauerstoffgabe die Intubationsrate am geringsten war, insbesondere bei schwerer respiratorischer Insuffizienz mit einem Horovitz-Quotienten (PaO 2 /FiO 2 ) von < 200 mmHg. Auch wenn die High-Flow-Sauerstoffgabe noch mit wenigen Studiendaten untermauert ist, wird sie bereits jetzt bei schwerer respiratorischer Insuffizienz der konventionellen Sauerstofftherapie vorgezogen [418].…”

Section: High-flow-sauerstoffunclassified

Leitlinie zur Diagnostik und Therapie von Patienten mit chronisch obstruktiver Bronchitis und Lungenemphysem (COPD)

et al. 2018

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This document is a revision of the guideline for diagnosis and treatment of COPD that replaces the version from 2007. A multitude of recent reports regarding risk factors, diagnosis, assessment, prevention and pharmacological as well as non-pharmacological treatment options made a major revision mandatory. The new guideline is based on the GOLD document taking into account specifics in Germany and Austria.

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“…Among patients with acute hypoxemic respiratory failure, the rates of intubation and of death are reportedly equivalent regardless of the prior use of HFNC, conventional oxygen therapy, or NPPV [1][2][3]. A prospective interventional study in which HFNC and NPPV were applied alternately in 14 patients with acute respiratory failure reported significantly better comfort with HFNC (on a 10-point scale: HFNC, 2.7 ± 1.8 vs. NPPV, 5.4 ± 3.1; p < 0.05), and the dyspnea score was significantly higher with HFNC (Borg scale: HFNC, 2.9 ± 1.8 vs. NPPV, 5.0 ± 3.3; p < 0.05) [23].…”

Section: Discussionmentioning

confidence: 99%

“…Among patients with acute hypoxemic respiratory failure, the use of HFNC is associated with rates of intubation and death equivalent to rates with commonly used conventional oxygen therapy and noninvasive positive pressure ventilation (NPPV) [1][2][3]. In addition, HFNC has characteristics that greatly contribute to maintaining a better quality of life (QOL), such as allowing oral intake, oral care, and conversation.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Tolerability of High-Flow Nasal Cannula Oxygen Therapy for Hypoxemic Respiratory Failure in Patients with Interstitial Lung Disease with Do-Not-Intubate Orders: A Retrospective Single-Center Study

et al. 2018

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Background: High-flow nasal cannula (HFNC) oxygen therapy may provide effective respiratory management of hypoxemic respiratory failure in patients with interstitial lung disease (ILD) with a do-not-intubate (DNI) order. Objectives: The aim was to assess the efficacy and tolerability of HFNC for these patients. Methods: We retrospectively reviewed the records of patients requesting a DNI order for hypoxemic respiratory failure associated with ILD, comparing treatment with HFNC and noninvasive positive pressure ventilation (NPPV). Outcomes measured were 30-day survival, in-hospital mortality, temporary interruption and discontinuation of the treatment at the patient’s request, adverse events, oral intake, and communication ability at the end of life. Results: A total of 84 patients (HFNC, n = 54; NPPV, n = 30) were analyzed. Neither 30-day survival (HFNC 31.5% vs. NPPV 30.0%; p = 0.86) nor in-hospital mortality (HFNC 79.6% vs. NPPV 83.3%; p = 0.78) differed significantly. The temporary interruption and discontinuation rates were significantly lower in the HFNC group than in the NPPV group (3.7 vs. 23.3%; p = 0.009 and 0 vs. 10%; p = 0.043, respectively), and that group had significantly fewer adverse events. Among patients who died in the hospital, those treated with HFNC had significantly better oral intake and ability to converse until just before death. Conclusion: HFNC had a survival rate equivalent to that of NPPV and was better tolerated by patients with hypoxemic respiratory failure associated with ILD who had a DNI order. HFNC allowed patients to eat and converse until just before death, suggesting that HFNC in these patients is a reasonable palliative treatment.

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High flow nasal cannula versus conventional oxygen therapy and non-invasive ventilation in adults with acute hypoxemic respiratory failure: A systematic review

Abstract: This review suggests that HFNC may be superior to COT in AHRF patients in terms of oxygenation, patient comfort, and work of breathing. It may be reasonable to consider HFNC as an intermediate level of oxygen therapy between COT and NIV.

Cited by 100 publications

References 35 publications

ERS statement on respiratory muscle testing at rest and during exercise

ERS statement on respiratory muscle testing at rest and during exercise

Leitlinie zur Diagnostik und Therapie von Patienten mit chronisch obstruktiver Bronchitis und Lungenemphysem (COPD)

Efficacy and Tolerability of High-Flow Nasal Cannula Oxygen Therapy for Hypoxemic Respiratory Failure in Patients with Interstitial Lung Disease with Do-Not-Intubate Orders: A Retrospective Single-Center Study

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