High-Flow Nasal Cannula Support Therapy: New Insights and Improving Performance

Hernández, Gónzalo; Roca, Oriol; Colinas, Laura

doi:10.1007/978-3-319-51908-1_20

Cited by 13 publications

(20 citation statements)

References 45 publications

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“…, Hernández et al . , Helviz & Einav ) and (5) decreased ventilatory drive and breathing effort in obstructive disease (Di Mussi et al . ), allowing the use of HOT in hypoxaemic and hypercapnic respiratory failure.…”

Section: Introductionmentioning

confidence: 99%

Prospective pilot study for evaluation of high‐flow oxygen therapy in dyspnoeic dogs: the HOT‐DOG study

Pouzot‐Nevoret

Hocine

Nègre

et al. 2019

J of Small Animal Practice

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Objectives To describe the use, effectiveness and tolerance of high‐flow oxygen therapy in dyspnoeic dogs. Materials and Methods Prospectively, dogs in acute respiratory distress admitted to an intensive care unit between January and May 2018 that failed to respond to nasal oxygen therapy and medical stabilisation after 30 minutes were transitioned to high‐flow oxygen therapy. High‐flow oxygen therapy, delivered an inspired oxygen fraction of 100% using an air/oxygen blender, active humidifier, single warmed tube and specific nasal cannula. Respiratory rate, pulse oximetry (SpO2), heart rate and a tolerance score were assessed every 15 minutes from T0 (under nasal oxygen) to 1 hour (T60), and PaO2 and PaCO2 at T0 and T60. Complications were recorded for each dog. Results Eleven dogs were included. At T60, PaO2, flow rate and SpO2 were significantly greater than at T0 (171 ± 123 versus 73 ± 24 mmHg; P=0.015; 18 ±12 L/minute versus 3.2 ± 2.0 L/minute, P<0.01; 97.7 ±2.3% versus 91.6 ±7.2%, P=0.03, respectively). There was no significant difference in PaCO2, respiratory rate or heart rate between T0 and T60. Tolerance was excellent, and there were no complications. Clinical Significance High‐flow oxygen therapy improves markers of oxygenation in dyspnoeic dogs and is an effective means to deliver oxygen with comfort and minimal complications.

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Section: Introductionmentioning

confidence: 99%

Prospective pilot study for evaluation of high‐flow oxygen therapy in dyspnoeic dogs: the HOT‐DOG study

Pouzot‐Nevoret

Hocine

Nègre

et al. 2019

J of Small Animal Practice

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“…In some previous reports, however, NIV increased PaO 2 /FiO 2 more than HFNC, even though HFNC prevented intubation better than NIV in patients with particularly low PaO 2 /FiO 2 . Potential patient–ventilator asynchronies and the low expiratory pressures might have contributed to the poor oxygenation during NIV in some of our patients . Because untreatable hypoxia is a strong indication for intubation, the potential effectiveness of HFNC in correcting hypoxia deserves more investigation, particularly in older end‐stage ARF patients with do‐not‐intubate status …”

Section: Clinical Characteristics Of the Study Groupmentioning

confidence: 99%

“…Conventional oxygen therapy (COT) is the main supportive therapy for acute respiratory failure (ARF) . Non‐invasive ventilation (NIV) reduces mortality and endotracheal intubation in ARF caused by acute exacerbations of chronic obstructive pulmonary disease or cardiogenic pulmonary edema, and is used also in geriatric wards .…”

Section: Clinical Characteristics Of the Study Groupmentioning

confidence: 99%

“…Non‐invasive ventilation (NIV) reduces mortality and endotracheal intubation in ARF caused by acute exacerbations of chronic obstructive pulmonary disease or cardiogenic pulmonary edema, and is used also in geriatric wards . High‐flow nasal cannula (HFNC) oxygen therapy delivers a high flow (up to 60 L/min) of a humidified and heated (from 31 to 37 °C) oxygen mixture through soft nasal prongs . The fraction of inspired oxygen (FiO 2 ) can be calculated and titrated between 0.21 and 1.0, and a continuous positive pressure is generated by the high flow in the airways .…”

Section: Clinical Characteristics Of the Study Groupmentioning

confidence: 99%

“…High‐flow nasal cannula (HFNC) oxygen therapy delivers a high flow (up to 60 L/min) of a humidified and heated (from 31 to 37 °C) oxygen mixture through soft nasal prongs . The fraction of inspired oxygen (FiO 2 ) can be calculated and titrated between 0.21 and 1.0, and a continuous positive pressure is generated by the high flow in the airways . HFNC was superior to COT and as effective as NIV in lowering the intubation rate in ARF from different etiologies .…”

Section: Clinical Characteristics Of the Study Groupmentioning

confidence: 99%

See 2 more Smart Citations

High‐flow nasal cannula oxygen therapy for acute respiratory failure in a non‐intensive geriatric setting

Fimognari

Rizzo

Cuccurullo

et al. 2018

Geriatrics Gerontology Int

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High-flow nasal cannula oxygen in patients with haematological malignancy: a retrospective observational study

et al. 2022

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BackgroundPatients with haematological malignancies (HM) face high rates of Intensive Care Unit (ICU) admission and mortality. High ow nasal cannula oxygen (HFNCO) is increasingly used to support HM patients in ward settings, but there is limited evidence on the safety and e cacy of HFNCO in this group. MethodsWe retrospectively reviewed all HM patients receiving ward-based HFNCO, supervised by a critical care outreach service (CCOS), from January 2014 -January 2019. ResultsWe included 130 consecutive patients. Forty-three (33.1%) were weaned off HFNCO without ICU admission. Eighty-seven (66.9%) were admitted to ICU, 20 (23.3%) required non-invasive and 34 (39.5%) invasive mechanical ventilation. ICU and hospital mortality were 42% and 55% respectively. Initial FiO 2 <0.4 (OR 0.27, 95% CI 0.09-0.81, p=0.019) and HFNCO use on the ward >1 day (OR 0.16, 95% CI 0.04, 0.59, p=0.006) were associated with reduced likelihood for ICU admission. Invasive ventilation was associated with reduced survival (OR 0.27, 95%CI 0.1-0.7, p=0.007). No signi cant adverse events were reported. ConclusionHM patients receiving ward-based HFNCO have higher rates of ICU admission, but comparable hospital mortality to those requiring CCOS review without respiratory support. Results should be interpreted cautiously, as the model proposed depends on the existence of CCOS.

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High-Flow Nasal Cannula Support Therapy: New Insights and Improving Performance

Abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

Cited by 13 publications

References 45 publications

Prospective pilot study for evaluation of high‐flow oxygen therapy in dyspnoeic dogs: the HOT‐DOG study

Prospective pilot study for evaluation of high‐flow oxygen therapy in dyspnoeic dogs: the HOT‐DOG study

High‐flow nasal cannula oxygen therapy for acute respiratory failure in a non‐intensive geriatric setting

High-flow nasal cannula oxygen in patients with haematological malignancy: a retrospective observational study

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