High Fischer ratio oligopeptides from hard-shelled mussel: Preparation and hepatoprotective effect against acetaminophen-induced liver injury in mice

Zheng, Shuo-Lei; Wang, Yue-Zheng; Zhao, Yu-Qin; Chi, Chang-Feng; Zhu, Wenxiu; Wang, Bin

doi:10.1016/j.fbio.2023.102638

Cited by 44 publications

(18 citation statements)

References 69 publications

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“…As an important antioxidant transcription factor, Nrf2 plays a crucial role in the body and cells against oxidative stress and inflammation. 72,73 In NAFLD mice with Nrf2 deficiency, oxidative stress and inflammatory response were more severe, and NAFLD was more likely to develop into NASH. 74 On the contrary, the activation of Nrf2 can reverse insulin resistance and hepatic steatosis and alleviate NASH and liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Mi,

Hu,

Liu

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Mi,

Hu,

Liu

et al. 2024

Food Funct.

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“…Antioxidant activity peptides play an important role in alleviating oxidative stress injury. [9][10][11] The development of dual-function peptides with antioxidant and antiadhesive activity is therefore important for antagonizing H. pylori infection and for the alleviation of gastric mucosal injury.…”

Section: Introductionmentioning

confidence: 99%

Purification, identification and molecular docking of dual‐functional peptides derived from corn protein hydrolysates with antioxidant and antiadhesive activity against Helicobacter pylori

Li,

Liu,

Miao

et al. 2024

J Sci Food Agric

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BackgroundMore than 50% of the world population is infected with Helicobacter pylori (H. pylori), which is classified as group I carcinogen by the WHO.ResultsCorn protein dual‐functional peptides were identified and functionally analyzed in vitro and in silico. Two novel dual‐functional peptides were identified as Cys‐Gln‐Asp‐Val‐Pro‐Leu‐Leu (CQDVPLL, CQ7) and Thr‐Ile‐Phe‐Pro‐Gln‐Cys (TIFPQC, TI6) by Nano‐LC‐MS/MS. The anti‐adhesive activity against Helicobacter pylori of CQ7 and TI6 was 45.17±2.41% and 48.62±1.84% at 4 mg/mL, respectively. In silico prediction showed that CQ7 and TI6 had good physicochemical properties. Molecular docking demonstrated that CQ7 and TI6 could bind to the adhesions BabA and SabA by hydrophobic interactions and hydrogen bonds, preventing Helicobacter pylori infection. Moreover, CQ7 showed strong antioxidant activity due to its unique amino acid composition.ConclusionThe present study demonstrated that the identified peptides CQ7 and TI6 possess antioxidant and anti‐adhesive effects, preventing Helicobacter pylori infection as well as alleviating oxidative injury to the gastric mucosa.This article is protected by copyright. All rights reserved.

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“…Moreover, bioactive compounds present in food exhibit reduced toxicity and a diminished occurrence of adverse effects in comparison to chemically synthesized pharmaceuticals . Mounting evidence indicates that bioactive substances derived from food have the potential to regulate inflammatory responses. − More intriguing subjects of investigation revolve around dry-cured hams, which are abundant in essential nutrients . Notably, a large number of proteins are enzymatically hydrolyzed into small molecular peptides with a variety of biological activities during the ham maturation process. , Studies have shown that small molecular peptides obtained from large molecular proteins after enzymatic hydrolysis are often more functional. , Currently, the majority of studies investigating the functional activity of ham peptides primarily concentrate on antioxidant properties, angiotensin-converting enzyme (ACE) inhibition, and dipeptide kininase-IV (DPP-IV) inhibition.…”

Section: Introductionmentioning

confidence: 99%

Identification and Mechanism Elucidation of Anti-Inflammatory Peptides in Jinhua Ham: An Integrative In Silico and In Vitro Study

Dong,

Ma,

Xie

et al. 2023

J. Agric. Food Chem.

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This study aimed to effectively identify anti-inflammatory peptides in Jinhua ham, a dry-cured meat product made from the hind legs of pigs by curing and fermenting processes, and elucidate their anti-inflammatory mechanism. The investigation involved a combination of chromatographic purification, in silico screening, and in vitro validation. The first peak of JHP (JHP-P1) was purified using two-part exchange chromatography, in which 3350 peptides were identified by nano-HPLC-MS/MS, among which QLEELKR and EAEERADIAESQVNKLR showed significant anti-inflammatory potential (prediction scores: 0.759 and 0.841). In molecular docking and in vitro RAW264.7 cell experiments, these peptides displayed a strong affinity for Toll-like receptor 4-myeloid differentiation-2 (TLR4-MD-2), specifically binding around Arg 380, Lys 475, His 401, Gln 423, Asp 426, etc. This binding inhibited TLR4 expression and prevented trimer formation about TLR4-MD-2 and lipopolysaccharide (LPS), strongly inhibiting the inflammatory cascade. JHP suppressed LPS-induced cytokine overproduction and partially inhibited the phosphorylation of proteins in the MAPK/NF-κB pathway. These results demonstrated that combining in silico methods (activity prediction and molecular docking) is an effective strategy for screening anti-inflammatory peptides. This study provided a theoretical basis for identifying more anti-inflammatory peptides and applying them in functional foods.

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High Fischer ratio oligopeptides from hard-shelled mussel: Preparation and hepatoprotective effect against acetaminophen-induced liver injury in mice

Cited by 44 publications

References 69 publications

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice

Purification, identification and molecular docking of dual‐functional peptides derived from corn protein hydrolysates with antioxidant and antiadhesive activity against Helicobacter pylori

Identification and Mechanism Elucidation of Anti-Inflammatory Peptides in Jinhua Ham: An Integrative In Silico and In Vitro Study

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