High-field, T2 reversed MRI of the hippocampus in transient global amnesia

Abstract

The data indicate that transient global amnesia may not be a benign entity. Delayed neuronal loss within CA1 area of Lorente de No may represent its important sequel.

An Updated Definition of Stroke for the 21st Century

“…66 Conversely, some conditions may present with stroke-like episodes and neurological symptoms that mimic CNS infarction (eg, mitochondrial encephalopathy, lactic acidosis, and stroke [MELAS], 67,68 posterior reversible encephalopathy syndrome, 69,70 and transient global amnesia). [71][72][73] However, although these conditions may have a component of ischemia, at this time, they are thought to have other primary mechanisms of cerebral damage and may be reversible without standard acute stroke therapies. The definition of CNS infarction may include atypical neurological symptoms when the symptoms are primarily attributed to focal (or multifocal) ischemia of the CNS.…”

Optimal Diffusion-Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia

“…21 Whatever its etiology, several authors have suggested that delayed neuronal injury in the hippocampus is the cause of the delayed appearance of the lesions on DWI. 9,22 It has also been speculated that delayed lesion appearance could be a result of progressive T2 prolongation of the lesions with time, as observed for thromboembolic infarctions. 12 This speculation arises from the finding that small acute infarctions in the basal ganglia frequently have greater DWI signal intensities on the second or third days than on the first day post-symptom onset.…”

Transient global amnesia following a transoceanic flight

“…9 There have been recent reports of the use of high-resolution T2 reversed MRI in obtaining detailed anatomy of fine structures in humans. 13 Some investigators have used diffusion-weighted imaging to examine the etiology of TGA, but the results have been controversial. 14 Several conditions have been reported to precipitate TGA: physical exertion, emotional stress, sexual intercourse, swimming in cold water, 1 coronary angiogra- 18 and reactivation of Epstein-Barr virus infection.…”