High field solid-state nmr of challenging nuclei in inorganic systems

ATM, a member of the phosphatidylinositol-3-kinase-like protein family, plays a central role in responding to DNA double-strand breaks and other lesions to protect the genome against DNA damage. Loss of ATM’s kinase function has been shown to increase the sensitivity of most cells to ionizing radiation. Therefore, ATM is thought to be a promising target for chemotherapy as a radiotherapy sensitizer. The mechanism of ATM in cancer treatment and the development of its inhibitors have become research hotspots. Here we present an overview of research concerning ATM protein domains, functions and inhibitors, as well as perspectives and insights for future development of ATM-targeting agents.

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High field solid-state nmr of challenging nuclei in inorganic systems

Cited by 2 publications

References 223 publications

Recent progress in solid-state NMR of spin-½ low-γ nuclei applied to inorganic materials

Recent progress in solid-state NMR of spin-½ low-γ nuclei applied to inorganic materials

Recent Advances in ATM Inhibitors As Potential Therapeutic Agents

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