High fibrin/fibrinogen degradation product to fibrinogen ratio is associated with 28-day mortality and massive transfusion in severe trauma

Lee, D. H.; Lee, B. K.; Noh, Soo Min; Cho, Y. S.

doi:10.1007/s00068-017-0844-0

Cited by 18 publications

(8 citation statements)

References 25 publications

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“…Many studies show that TBI is commonly caused by traffic accidents 21,22 . Motorized vehicle accidents are responsible for the majority of TBI-associated deaths among young adults 2,23 .…”

Section: Onsdmentioning

confidence: 99%

The association between intracranial pressure and optic nerve sheath diameter on patients with head trauma

Çelik

Demiryürek

2021

Arq. Neuro-Psiquiatr.

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Background: Although intracranial pressure (ICP) monitoring is the gold standard method for measuring intracranial pressure after traumatic brain injury, optic nerve sheath diameter (ONSD) measurement with ultrasound (US) is also used in the evaluation of ICP. Objective: To investigate the association between a series of OSND measurements by US and changes in clinical presentation of the patient. Methods: Prospective study including 162 patients with traumatic brain injury. Age, sex, cerebral CT findings, ONSD levels by US at minutes 0, 60, and 120, Glasgow Coma Scale (GCS) within same period, change of consciousness, treatment, and mortality data were reviewed. The association of ONSD levels with GCS, change of consciousness, treatment, and mortality was evaluated. Results: There was no difference in ONSD changes in the patients’ sample within the period (p=0.326). ONSD significantly increased in patients who died (p<0.001), but not in those who survived (p=0.938). There was no significant change in ONSD of the patients who received anti-edema therapy (p=801), but significantly increased ONSD values were found in those who received anti-edema therapy (p=0.03). Patients without change of consciousness did not have any significant change in ONSD (p=0.672), but ONSD values increased in patients who consciousness became worse, and decreased in those who presented a recovery (respectively, p<0.001, p=0.002). A negative correlation was detected between ONSD values and GSC values measured at primary, secondary, and tertiary time periods (for all p<0.001). Conclusions: ONSD follow-up may be useful to monitor ICP increase in patients with acute traumatic brain injury.

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“…Many studies show that TBI is commonly caused by traffic accidents 21,22 . Motorized vehicle accidents are responsible for the majority of TBI-associated deaths among young adults 2,23 .…”

Section: Onsdmentioning

confidence: 99%

The association between intracranial pressure and optic nerve sheath diameter on patients with head trauma

Çelik

Demiryürek

2021

Arq. Neuro-Psiquiatr.

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“…Increased fibrin and fibrinogen degradation products are associated with the presence of coagulopathy, increased transfusion needs, injury severity, and mortality. 74,91,92 Severe tissue injury combined with hemorrhagic shock induces an acute release of tPA, a known initiator of proteolysis, into the blood. 93 The subsequent fibrinogenolysis has been described experimentally to proceed in a predictable fashion.…”

Section: Fibrinogen Proteolysismentioning

confidence: 99%

Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy

John

White

2020

Semin Thromb Hemost

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Trauma induces a change in nearly every observable aspect of hemostasis, generally tipping the balance toward trauma-induced coagulopathy (TIC) and bleeding in the critical early stages. Two particularly important aspects of TIC are platelets and fibrinogen, which are the primary determinants of clot formation and hemostasis. Their loss and dysfunction represent important transition points between coagulopathy phenotypes, highlighting their mechanistic roles in TIC as well as unveiling new potential avenues toward important diagnostic and therapeutic interventions. This review synthesizes current knowledge of platelets and fibrinogen during TIC, with a focus on emerging concepts related to their dysfunction and development of new therapeutic approaches.

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“…Several small studies have assessed the short-term mortality and poor prognosis in patients with TBI. For example, studies have found that higher levels of D-dimer are associated with higher in-hospital, 28-day ( Allard et al, 2009 ; Lee et al, 2018 ), and 30-day mortality ( Yuan et al, 2012 ). Fujiwara et al analyzed a multicenter TBI database and found that D-dimer levels at admission were associated with poor GOS scores and mortality at 6 months ( Fujiwara et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Plasma D-dimer levels are a biomarker for in-hospital complications and long-term mortality in patients with traumatic brain injury

Chen,

Wang,

Liu

et al. 2023

Front. Mol. Neurosci.

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IntroductionTraumatic brain injury (TBI) is a major health concern worldwide. D-dimer levels, commonly used in the diagnosis and treatment of neurological diseases, may be associated with adverse events in patients with TBI. However, the relationship between D-dimer levels, TBI-related in-hospital complications, and long-term mortality in patients with TBI has not been investigated. Here, examined whether elevated D-dimer levels facilitate the prediction of in-hospital complications and mortality in patients with TBI.MethodsOverall, 1,338 patients with TBI admitted to our institute between January 2016 and June 2022 were retrospectively examined. D-dimer levels were assessed within 24 h of admission, and propensity score matching was used to adjust for baseline characteristics.ResultsAmong the in-hospital complications, high D-dimer levels were associated with electrolyte metabolism disorders, pulmonary infections, and intensive care unit admission (p < 0.05). Compared with patients with low (0.00–1.54 mg/L) D-dimer levels, the odds of long-term mortality were significantly higher in all other patients, including those with D-dimer levels between 1.55 mg/L and 6.35 mg/L (adjusted hazard ratio [aHR] 1.655, 95% CI 0.9632.843), 6.36 mg/L and 19.99 mg/L (aHR 2.38, 95% CI 1.416–4.000), and >20 mg/L (aHR 3.635, 95% CI 2.195–6.018; p < 0.001). D-dimer levels were positively correlated with the risk of death when the D-dimer level reached 6.82 mg/L.ConclusionOverall, elevated D-dimer levels at admission were associated with adverse outcomes and may predict poor prognosis in patients with TBI. Our findings will aid in the acute diagnosis, classification, and management of TBI.

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High fibrin/fibrinogen degradation product to fibrinogen ratio is associated with 28-day mortality and massive transfusion in severe trauma

Abstract: High FDP/fibrinogen ratio on arrival is a predictor of 28-day mortality and the requirement for massive transfusion in severe trauma.

Cited by 18 publications

References 25 publications

The association between intracranial pressure and optic nerve sheath diameter on patients with head trauma

The association between intracranial pressure and optic nerve sheath diameter on patients with head trauma

Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy

Plasma D-dimer levels are a biomarker for in-hospital complications and long-term mortality in patients with traumatic brain injury

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