Abstract:Previous studies have identified Th17 to be highly pathogenic during immune dysregulation. We have previously shown that chronic high fat diet (HFD) led to significant kidney medullary interstitial fibrosis and aortic hypertrophy compared to normal diet intake. Numerous studies have identified a connection between high fat and high salt diets and an increase in pathogenic Th17 cells. Although little is understood about Th17 activation in the gut and kidney when high fat and high salt diets are combined (HF/HS)… Show more
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