High Fat High Calories Diet (HFD) Increase Gut Susceptibility to Carcinogens by Altering the Gut Microbial Community

Jin, Hei-Ying; Zhang, Chunxia

doi:10.7150/jca.43561

Cited by 22 publications

(24 citation statements)

References 21 publications

(21 reference statements)

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“…Increase of Clostridium XVIII is reported in various pro-inflammatory and pathological conditions, as in gastric cancer patients in the perioperative period [22] or in those with high fat diets [23]. Its increase in CDI has been sporadically reported [20], but this taxon is not commonly listed as associated with CDI.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of Clostridium XVIII are controversial, as some species produce exotoxins and have a pro-inflammatory potential, while other act as probiotics [ 21 ]. Increase of Clostridium XVIII is reported in various pro-inflammatory and pathological conditions, as in gastric cancer patients in the perioperative period [ 22 ] or in those with high fat diets [ 23 ]. Its increase in CDI has been sporadically reported [ 20 ], but this taxon is not commonly listed as associated with CDI.…”

Section: Discussionmentioning

confidence: 99%

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Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections

et al. 2020

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Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea, especially in hospitalized elderly patients, representing a global public health concern. Clinical presentations vary from mild diarrhea to severe pseudomembranous colitis that may progress to toxic megacolon or intestinal perforation. Antibiotic therapy is recognized as a risk factor and exacerbates dysbiosis of the intestinal microbiota, whose role in CDI is increasingly acknowledged. A clinically challenging complication is the development of recurrent disease (rCDI). In this study, using amplicon metagenomics, we compared the fecal microbiota of CDI and rCDI patients (sampled at initial and recurrent episode) and of non-infected controls. We also investigated whether CDI severity relates to specific microbiota compositions. rCDI patients showed a significantly decreased bacterial diversity as compared to controls (p < 0.01). The taxonomic composition presented significant shifts: both CDI and rCDI patients displayed significantly increased frequencies of Firmicutes, Peptostreptococcaceae, Clostridium XI, Clostridium XVIII, and Enterococcaceae. Porphyromonadaceae and, within it, Parabacteroides displayed opposite behaviors in CDI and rCDI, appearing discriminant between the two. Finally, the second episode of rCDI was characterized by significant shifts of unclassified Clostridiales, Escherichia/Shigella and Veillonella. No peculiar taxa composition correlated with the severity of infection, likely reflecting the role of host-related factors in determining severity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections

et al. 2020

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“…Animal feeding as our previous report [2]. Feed is cobalt 60 radiation-sterilized pellets for rats and mice (Nanjing Jiangning Qinglongshan feed Company), high-fat feed (formulation: 20 g lard, 5 g cholesterol, 10 g Tween 80, add water to 50 ml).…”

Section: Methodsmentioning

confidence: 99%

“…Peyman et al [14] studies had showed that p-Cymene has anti-inflammatory properties. Our previous study has found that HFD increase gut susceptibility to carcinogens by altering the gut microbial community [2]. However, up to now, its anti-tumor and antioxidation mechanism of P-cymene is still unclear.…”

Section: Ivyspringmentioning

confidence: 97%

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P-cymene prevent high-fat diet-associated colorectal cancer by improving the structure of intestinal flora

Jin¹,

Li²,

Zhang³

et al. 2021

J. Cancer

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Objective: To investigate the preventing effect of P-cymene on high fat diet-related colorectal cancer and its mechanism. Methods: Forty Wistar rats were randomly divided into G1 group (high-fat diet), G2 group (high-fat diet + DMH), G3 group (high-fat diet + P-cymene), and G4 group (high-fat diet + DMH + P-cymene).G2 and G4 groups were subcutaneously injected with dimethylhydrazine (DMH), and G3 and G4 groups were intragastrically administered with P-cymene to investigate the effects of P-cymene on tumor formation, inflammatory factors, glucose, lipid metabolism and gut microbes. Results: No tumors were formed in the high-fat diet group (G1) or the high-fat diet + P-cymone group (G3). 7 rats (70%) of the high-fat diet + DMH group (G2) developed 8 cancerous nodules, including 6 adenocarcinomas and 2 signet ring cell carcinomas; 4 rats (40%) in the high-fat diet + DMH + P-cymene group (G4) group formed 4 cancerous nodules, all of which were adenocarcinoma. There was no significant difference in the changes of glucose and lipid metabolism in each group. After the use of P-cymene, IL-1 decreased, IL-6 increased, and LEP decreased in the G4 group.The difference was statistically significant.The contents of Candida and Unclassified Bacteria in the G3 group rats were significantly lower than those in the G1 group.At the species level comparison, compared with the G2 group, the content of Clostridium XlVa in the intestinal tract of the G2 group rats was significantly increased compared to the G1 group. Conclusion:In this study, it was found that p-cymenen can prevent the occurrence of colorectal cancer related to high-fat and high-calorie diet. The mechanism may be is reducing the expression of inflammatory factors such as IL-1 and LEP, increasing the expression of inflammatory factors of IL-6, and promoting the growth of probiotics such as bifidobacteria, isobacteria and clostridium IV in the intestinal tract.

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Development and treatment of colorectal cancer: Insights from multi‐kingdom microbiota

et al. 2023

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Colorectal cancer (CRC) is a multistage and highly heterogeneous malignant disease that mostly occurred in aged people accompanied by microbiota alteration. Emerging evidence has uncovered the role of bacterial microbiota in the initiation and development of CRC. However, the effects of nonbacterial members inhabiting the human body, such as fungi, archaea, and viruses, have been largely ignored. The multi‐kingdom microbiota can be altered by dietary exposures and probiotic supplements. Furthermore, the efficacy of antitumor therapeutic strategies, such as radiotherapy, chemotherapy, and immunotherapy, are also closely associated with the alteration of multi‐kingdom microbiota. In this review, we describe CRC‐associated multi‐kingdom microbiota dysbiosis and the role of daily diet on CRC progression through microbiota alteration. We then discuss the impact of microbiota in different CRC therapies and highlight the advances as well as challenges in understanding how multi‐kingdom microbiome impacts the outcome of CRC.

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High Fat High Calories Diet (HFD) Increase Gut Susceptibility to Carcinogens by Altering the Gut Microbial Community

Cited by 22 publications

References 21 publications

Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections

Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections

P-cymene prevent high-fat diet-associated colorectal cancer by improving the structure of intestinal flora

Development and treatment of colorectal cancer: Insights from multi‐kingdom microbiota

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