High-fat diet unveils an enhancer element at the Ped/Pea-15 gene responsible for epigenetic memory in skeletal muscle

Vastolo, Viviana; Nettore, Immacolata Cristina; Ciccarelli, Marco; Albano, Luigi; Raciti, Gregory Alexander; Longo, Michele; Béguinot, Francesco; Ungaro, Paola

doi:10.1016/j.metabol.2018.06.001

Cited by 12 publications

(6 citation statements)

References 46 publications

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“…Previous studies reported that type 2 diabetes was induced by chronic high-fat feeding in mice, in which severe increases in fasting blood glucose and failure of glucose uptake to skeletal muscle were noted [ 11 , 13 , 14 , 23 ]. These results of the glucose tolerance test indicated the successful induction of diabetes by a high-fat diet for 2 months (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Early high-fat feeding improves histone modifications of skeletal muscle at middle-age in mice

2020

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The purpose of the present study was to investigate how the effects of high-fat diet feeding on the skeletal muscle persisted during aging using mice. Post-weaned male mice were fed a high-fat diet between 1-and 3-mo-old followed by return to supply a normal diet until 13-mo-old. Monthly physical tests demonstrated that age-related glucose intolerance that was generally developed after 10-mo-old in the control mice was significantly improved in mice fed a high-fat diet. Interestingly, mRNA expressions of Pdk4, Ucp3, and Zmynd17 were up-regulated by high-fat feeding and persisted in the tibialis anterior muscle until 13-mo-old. At Pdk4 and Ucp3 loci, enhanced distributions of active histone modifications were noted in the high-fat-fed mice at 13-mo-old. In contrast, age-related accumulation of histone variant H3.3 at these loci was suppressed. These results indicated that epigenetic modifications caused by early nutrition mediated the changes in skeletal muscle gene expression during aging.

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Section: Discussionmentioning

confidence: 99%

Section: Metabolic Impairmentmentioning

confidence: 99%

Early high-fat feeding improves histone modifications of skeletal muscle at middle-age in mice

2020

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“…The most studied epigenetic processes controlling gene expression through changes of chromatin architecture and binding of transcription factors are the methylation of cytosines within CpG dinucleotides, post-translational modifications of histones (i.e., acetylation/deacetylation or methylation/demethylation of lysine residues) catalyzed by histone-modifying enzymes [ 1 ], and microRNAs regulating multiple mRNAs [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Environmental factors, including EDCs, may be involved in obesity development by altering the epigenetic mechanisms [ 26 , 27 , 28 ] ( Figure 1 ).…”

Section: Epigenetics and Obesitymentioning

confidence: 99%

Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity

et al. 2021

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The incidence of obesity has dramatically increased over the last decades. Recently, there has been a growing interest in the possible association between the pandemics of obesity and some endocrine-disrupting chemicals (EDCs), termed “obesogens”. These are a heterogeneous group of exogenous compounds that can interfere in the endocrine regulation of energy metabolism and adipose tissue structure. Oral intake, inhalation, and dermal absorption represent the major sources of human exposure to these EDCs. Recently, epigenetic changes such as the methylation of cytosine residues on DNA, post-translational modification of histones, and microRNA expression have been considered to act as an intermediary between deleterious effects of EDCs and obesity development in susceptible individuals. Specifically, EDCs exposure during early-life development can detrimentally affect individuals via inducing epigenetic modifications that can permanently change the epigenome in the germline, enabling changes to be transmitted to the next generations and predisposing them to a multitude of diseases. The purpose of this review is to analyze the epigenetic alterations putatively induced by chemical exposures and their ability to interfere with the control of energy metabolism and adipose tissue regulation, resulting in imbalances in the control of body weight, which can lead to obesity.

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“…By contrast, H3K9me3 (trimethylation on Lys 9 of histone 3) and H3K27 me3 (trimethylation on Lys 27 of histone 3) are two histone marks with a repressive role on gene promoters [ 14 , 15 ]. H3K4me1 (monomethylation of histone H3 at lysine 4) and H3K27ac (acetylation of histone H3 at lysine 27) are generally present in enhancer elements [ 16 , 17 ]. Histone modifications are mediated by several enzymes, such as histone acetyltransferases (HAT) (p300 and CREB-binding protein), histone deacetylases (HDAC) (HDAC1-11 and sirtuins), histone lysine methyltransferases (HMTs), and lysine demethylases (HDMs).…”

Section: Overview Of the Epigenetics’ Processesmentioning

confidence: 99%

Nucleic Acid Aptamers Targeting Epigenetic Regulators: An Innovative Therapeutic Option

et al. 2018

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Epigenetic mechanisms include DNA methylation, posttranslational modifications of histones, chromatin remodeling factors, and post transcriptional gene regulation by noncoding RNAs. All together, these processes regulate gene expression by changing chromatin organization and DNA accessibility. Targeting enzymatic regulators responsible for DNA and chromatin modifications hold promise for modulating the transcriptional regulation of genes that are involved in cancer, as well as in chronic noncommunicable metabolic diseases like obesity, diabetes, and cardiovascular diseases. Increasingly studies are emerging, leading to the identification of specific and effective molecules targeting epigenetic pathways involved in disease onset. In this regard, RNA interference, which uses small RNAs to reduce gene expression and nucleic acid aptamers are arising as very promising candidates in therapeutic approach. Common to all these strategies is the imperative challenge of specificity. In this regard, nucleic acid aptamers have emerged as an attractive class of carrier molecules due to their ability to bind with high affinity to specific ligands, their high chemical flexibility as well as tissue penetration capability. In this review, we will focus on the recent progress in the field of aptamers used as targeting moieties able to recognize and revert epigenetics marks involved in diseases onset.

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High-fat diet unveils an enhancer element at the Ped/Pea-15 gene responsible for epigenetic memory in skeletal muscle

Cited by 12 publications

References 46 publications

Early high-fat feeding improves histone modifications of skeletal muscle at middle-age in mice

Early high-fat feeding improves histone modifications of skeletal muscle at middle-age in mice

Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity

Nucleic Acid Aptamers Targeting Epigenetic Regulators: An Innovative Therapeutic Option

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