High-fat diet intake from senescence inhibits the attenuation of cell functions and the degeneration of villi with aging in the small intestine, and inhibits the attenuation of lipid absorption ability in SAMP8 mice

Abstract

We examined the effect of a high-fat diet from senescence as a means of preventing malnutrition among the elderly. The senescence-accelerated mouse P8 was used and divided into three groups. The 6C group was given a normal diet until 6 months old. The 12N group was given a normal diet until 12 months old. The 12F group was given a normal diet until 6 months old and then a high-fat diet until 12 months old. In the oral fat tolerance test, there was a decrease in area under the curve for serum triacylglycerol level in the 12N group and a significant increase in the 12F group, suggesting that the attenuation of lipid absorption ability with aging was delayed by a high-fat diet from senescence. To examine this mechanism, histological analysis in the small intestine was performed. As a result, the degeneration of villi with aging was inhibited by the high-fat diet. There was also a significant decrease in length of villus in the small intestine in the 12N group and a significant increase in the 12F group. The high-fat diet from senescence inhibited the degeneration of villi with aging in the small intestine, and inhibited the attenuation of lipid absorption ability.

Association of Lifelong Intake of Barley Diet with Healthy Aging: Changes in Physical and Cognitive Functions and Intestinal Microbiome in Senescence-Accelerated Mouse-Prone 8 (SAMP8)

“…Body weight of mice in this study was 1.5-fold higher and the maximum peak of body weight occurred at approximately 20 weeks later (Figure 2B) compared to that of mice in our previous study [15]. Yamamoto et al reported that fat absorption ability decreases with age due to the degeneration of villi in the small intestine, and an oral high-fat diet (fat energy ratio; 30%) inhibited the attenuation of lipid absorption ability in SAMP8 mice [34]. We speculate that the mild high-fat diets (energy ratio; 27%) may also prevent the attenuation of lipid absorption ability with aging in this study.…”

“…Moreover, the mean blood glucose level at 55 weeks old decreased, except for one surviving mouse with severe diabetes (whose blood glucose was more than 500 mg/dL). We assumed that decreased nutrient absorption due to aging [34] resulted in the low levels of blood glucose (reduced approximately 60 mg/dL) in SAMP8 mice. Because the susceptibility of SAMP8 mice to diabetes was affected by the fat–energy ratio (low or high fat diet), the ability of intestinal absorption, and breeding circumstance (group-breeding or not), the SAMP8 mice might be a suitable type 2 diabetes model for humans, and not only a model of dementia or locomotor defect with aging.…”

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

“…Dietary lipid absorption is known to be closely associated with the structure of the small intestinal mucosal membrane. Yamamoto et al (29) suggested that the length of the villi in the small intestine was associated and parallel with lipid-induced hypertriglyceridemia and the TAG level of the serum and liver in mice. However, it has been indicated that a single administration of the EW and EWH did not change the mucosal structure or its function in the small intestine.…”

Gastrointestinal Motility, Mucosal Mast Cell, and Intestinal Histology in Rats: Effect of Prednisone

“…In previous studies, we already showed a hastened gastric emptying in male rats treated with prednisone after intermediate dose [ 23 ]. As prednisone was able to decrease the villus height in duodenum, the association of both data suggests a change in gastrointestinal absorption which may compromise the uptake of essential nutrients [ 24 ] and also the bioavailability of drugs since intraluminal environment has a great influence on the performance of the dosage forms administered orally [ 25 , 26 ].…”